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VIERNES / FRIDAY<br />

282<br />

the femoral component and the posterior femoral<br />

cortex as a consequence of unremoved<br />

oseophytes or inadequate posterior capping<br />

may be responsible for painful limited motion.<br />

Plain x-rays or CT scans may detect most of<br />

the mechanically related factors.<br />

A painful stiff knee without identifi able mechanical<br />

reason has its origin in a biological<br />

process which induces inflammation and<br />

scarring of the synovium and adjacent<br />

connective tissue such as the collateral<br />

ligaments, the patellar tendon, the fat pad<br />

and ultimately the subcutaneous layer and<br />

the skin. Arthrofi brosis8 of the knee is the<br />

end stage, in the severest case it results in<br />

patella baja9.<br />

Six biological origins of a painful stiff knee<br />

have to be considered if mechanical factors<br />

have been ruled out:<br />

(1) Recurrent hemarthrosis<br />

(2) Infection<br />

(3) Herotopic ossifi cation<br />

(4) Allergy<br />

(5) Complex regional pain syndrome.<br />

Recurrent hemarthrosis is a clinical diagnosis<br />

in the early postoperative periode. Aspiration<br />

is the fi rst diagnostic and therapeutic method<br />

of choice, but if recurrency persist arthrotomy<br />

is occasionally required. Aspiration is also<br />

mandatory if pain and swelling increase in the<br />

early postoperative days, accompanied by<br />

temperature elevation and increase of white<br />

blood count (WBC). Elevation of C-reactive<br />

protein (CRP) is normal in the fi rst 3 postoperative<br />

weeks and is therefore useless in the<br />

early postoperative period.<br />

However, if it does not drop constantly or rises<br />

even further, infection must be suspected. If<br />

WBC and CRP rise after months or years<br />

hematogenous infection is suspected. Satisfactory<br />

diagnosis can only be made if culture<br />

of synovial fl uid reveals a germ. If no germ is<br />

identifi ed, diagnosis may remain uncertain.<br />

Particularly a low-grade infection, where the<br />

postoperative course is unsatisfactory and<br />

the knee remains warm, swollen, painful,<br />

and with reduced arc of motion, is diffi cult to<br />

manage. The knee may not be differentiated<br />

from a condition with has been known by several<br />

terms: algodystrophy, refl ex sympathetic<br />

dystrophy, M. Sudeck, causalgia and others.<br />

Complex regional pain syndrome (CRPS) is a<br />

description created by the IASP (International<br />

Association for the Study of Pain) for an infl<br />

ammatory disease after surgery or trauma<br />

which summarizes these terms. CRPS I is<br />

associated with skin nerve damage during<br />

surgery, and CRPS II is not. Ethiopathology<br />

is not well understood, but in both cases the<br />

sympathetic (autonomous), sensory and motor<br />

nerve system is disturbed. The symptoms<br />

of acute arthrofi brosis as a consequence<br />

of CRPS consist of pain at rest, which can<br />

range between moderate and severe, hyperalgia,<br />

dysaesthesia and skin temperature<br />

dysregulation. The skin of the index knee can<br />

be colder (in 20% of the cases) or warmer<br />

(in 80% of the cases) than the contralateral<br />

knee. Skin color turns into red because of increased<br />

vascularisation, or it can be pale and<br />

cyanotic if skin vascularisation is decreased.<br />

Hyperhydrosis may predominate (50% of the<br />

cases) over hypohydrosis (20% of the cases).<br />

CRPS I may have a less severe course and<br />

patients suffer often only of pain during knee<br />

motion. Attemts do differentiate CRPS from<br />

low-grade infection using modern diagnostic<br />

tools such as positron emission tomography<br />

are frustrating10. Arthroscopy is indicated to<br />

obtain synovium biopsy for tissue culture and<br />

histological examination may occasionally<br />

help to rule out either CRPS or infection.<br />

Heterotopic ossifi cation is easy to detect<br />

on x-rays in the advanced stage, the early<br />

stage may best be evaluated with technetium<br />

scans.<br />

Allergy to orthopedic implants is a controversial<br />

tissue11. Fact is that patients may be<br />

allergic to kalium dichromate, nickel sulfate,<br />

and cobalt chloride, as well to methyl methacrylate<br />

and antibiotics used with bone cement,<br />

all materials used with orthopaedic implants.<br />

There is no evidence so far to support the<br />

hypothesis that these materials induce tissue<br />

reactions that may result in infl ammation and<br />

cell proliferation resulting in swelling, arthro-

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