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MARTES / TUESDAY<br />

76<br />

The information suggests that excellent<br />

long-term results can be achieved with a<br />

well-conceived design and good surgical<br />

technique.<br />

OSSEOINTEGRATION IN<br />

PRIMARY CEMENTLESS<br />

HIP FIXATION<br />

J. D. Blaha, M.D.<br />

University of Michigan. Medical<br />

School, USA<br />

Osseointegration implies the formation of a<br />

“single” (i.e., integrated unit) between bone<br />

and, in the case of a joint replacement arthroplasty,<br />

a prosthetic component. Although it<br />

has not always been such in common usage,<br />

osseointegration and fi xation are synonymous<br />

terms. Fixation, for total joint replacement,<br />

implies that a prosthesis is bonded<br />

to the bone in such a way that there is no<br />

relative motion at the interface between the<br />

prosthesis and the bone. Osseointegration is<br />

a term that describes the histological features<br />

by which this fi xation is achieved and implies<br />

the mechanical features of a fi xed implant.<br />

Many total joint prostheses have been successful<br />

at the <strong>hip</strong>. There are numerous<br />

shapes and sizes of implants that have associated<br />

with successful clinical outcomes.<br />

The clinician is presented with a plethora<br />

of seemingly contradicting claims regarding<br />

the need for certain design features of<br />

implants in order to achieve a successful<br />

result. (E.g., “maximum fi t and fi ll”, porous<br />

coating, hydroxylapetite coating, “scratch fi t”<br />

grit-blasting etc.)<br />

This presentation suggests a unifying explanation<br />

for the success of implants. This<br />

explanation is based on dividing the time after<br />

implantation into four periods: primary stability,<br />

intermediate stability, secondary stability<br />

and long-term remodeling.<br />

Primary stability: For a cementless implant<br />

this period would be during the operative<br />

intervention when the prosthesis is inserted<br />

into the bone. The interference of the implant<br />

in the bone leads to a “press-fi t” that will hold<br />

the implant stable.<br />

Intermediate stability: For a cementless implant<br />

this period begins after primary stability<br />

is achieved in the OR and ends when bone<br />

apposition to the implant leads to secondary<br />

stability and osseointegration.<br />

Secondary stability: When bone apposition<br />

to the implant has progressed so that<br />

the implant has been “fi xed” (i.e., no relative<br />

motion at the interface of the implant to the<br />

bone) secondary stability has occurred. The<br />

time required to achieve this is not certain<br />

but bone healing is generally thought to take<br />

between 6 and 12 weeks.<br />

Long-term remodeling: The progressive<br />

change of bone at the interface to hypertrophy<br />

in areas of increased load and atrophy<br />

in areas of no load (i.e., the expression of<br />

Wolf’s law of bone) leads to this long-term<br />

remodeling. Other conditions at the interface<br />

(e.g., fracture, infection, debris induced bone<br />

resorption etc.) can lead to dissolution of the<br />

bone and loosening of the implant.<br />

In fact, this same concept can be applied to<br />

cemented arthroplasty as the ultimate fi xation<br />

of a cemented joint must be against live bone<br />

and the term osseointegration is appropriate<br />

for the cemented joint as well.

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