l - People

!
Because it cuts the backbone at two points, however, FO is limited to proteins with
single- or double-stranded hinges. Also, the code neglects bound metals. Since these are
highly coordinated, we will argue that accuracy may be limited when metal binding
contributes significantly to the stability and motion characteristics of the protein.
Definition of HingeMaster
As pointed out previously, the described algorithms use substantially different
information to make hinge predictions. Consequently they have different strengths and
yield very different results. StoneHinge is good at finding the general region of the hinge,
but often overestimates the size of the hinge region. hNMd faces similar limitations. FO
and hNMb are very precise but are limited to single or double-stranded hinges. TLSMD,
on the other hand, makes a small number of predictions, well spaced apart, one or more
of which often lie exactly on or very close to domain hinges, and the rest of which are
incorrect or lie on points of non-domain hinge flexibility.
Combining various predictors by consensus[38] or other means is not unprecedented.
We did this by creating HingeMaster, the output of which is a weighted vote of the
individual predictors:
x HingeMaster(i) =
where
$ % cx c(i)
"c #C
177
[5]