l - People

manual culling too stringent would simply have resulted in a dataset too small to be
statistically meaningful. For these reasons, the computer annotated dataset was not used
in most of this work. Nonetheless, the computer annotated dataset is arguably more
objective then the manually annotated set described below, and so is made available to
the community.
To address the accuracy issues, we decided to generate a manually annotated set of
hinges -- the Hinge Atlas. To generate this set we first created the Hinge Annotation
Tool which can also be used by the public as we will now explain.
The Hinge Annotation Tool
The creation of publicly accessible tools for manual annotation of hinges involved
significant changes to the morph page. The morph page is the primary point on
MolMovDB for analyzing single morphs. It is accessible from the “movies” page or
through our search tool, both linked to or visible on our front page. Our server also
provides a link to this page in an email sent to the submitter of each morph request. We
added all of the new tools to the “Hinge Analysis” tab on this page. The first of these is
the Hinge Annotation tool. Each of three rows of “arrow” buttons on this tool move a
highlighted window of two residues along the protein chain, allowing the user to
highlight up to three hinges in a protein. The “Show all” button then highlights all
selected residues in the Jmol viewer window. Once the user is satisfied with the hinge
selection, clicking “Submit” records this selection in the database. Once the morph page
is regenerated, a “Show public hinge” button will be visible which, when clicked,
highlights the selected residues. Lastly, the user can use a pointing device to reorient the
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