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Figures<br />

Figure 4.1: ROC curve for hNMa<br />

Lower values of the first normal mode displacement (solid line) correspond to hinges, as<br />

shown by an area under the curve significantly greater than 0.5. The same is not true of<br />

the second (dashed line) and third (dotted line) normal modes, which have almost no<br />

predictive power. The slope at the origin is not very steep, reflecting the fact that wide<br />

regions of proteins often had small or zero displacement, leading to ambiguous<br />

predictions. Regions of high displacement, however, were rather confidently excluded<br />

from containing hinges.<br />

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