l - People

169±1, and 190±1. The false positive boundary at 44/45 seen in this figure is introduced
when a 5 th chain segment is requested.
Human lactoferrin
Morph ID: f964647-15593 PDB ID: 1LFG
HAG hinges: 90,91,250,251
Human lactoferrin (hLF) is an iron-binding glycoprotein found in exocrine fluids
produced by mammals, including milk, saliva, tears, bile, pancreatic fluid, and mucous
secretions. It has broad spectrum antibacterial properties and seems to regulate the
absorption and excretion of iron in infants.
The hinge bending motion of lactoferrin has been studied in detail. The protein consists
of N- and C- terminal lobes which are highly homologous and are presumed to have
arisen from gene duplication. Each lobe is further subdivided into two domains, N1 and
N2, and C1 and C2. In the iron-free form, a deep cleft appears between N1 and N2. No
such cleft appears in the C-lobe either in the iron free or iron bound form, but this is
believed to be an artifact of crystallization. In the iron-bound form, N1 and N2 are close
together about a common hinge, located between residues 90 and 91, and 250 and 251
according to Gerstein et al. This is in perfect agreement with the independent annotation
made in this work.
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