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The Development of Circadian Rhythm
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Table of Contents LIST OF FIGURES .
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7.1 Analysis of infant sleep measur
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List of Figures Figure 1.1 - Diagra
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List of Tables Table 3.1 - Descript
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1 Introduction Happiness is not a m
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Each of these independently is impo
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There is general agreement, that al
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Summary 1. Development encompasses
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Figure 1.1 - Diagram illustrating c
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A phase shift is used to describe a
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1.4 Ontogeny in Human Infants Well
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1.5.2 Circadian Rhythms in Temperat
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1.5.4 Factors affecting Temperature
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1.6 Melatonin (Reviewed in Cardinal
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mechanism by which this occurs is n
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It is at this time that infant slee
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1.7 Cortisol Cortisol is a hormone,
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1.7.3 Circadian pattern of Cortisol
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In a separate study, Weerth et al u
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Summary 1. Cortisol is crucial to a
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NREM sleep has 4 stages. It occupie
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1.8.1 Functions of Sleep The functi
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1.8.3 Ontogeny of Sleep in Infants
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Sleep can clearly be used as marker
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For the purpose of this study, the
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Summary 1. Sleep is defined by lack
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Overall the SCN generates signals (
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Figure 1.2 - The mammalian circadia
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1.9.3 Molecular Components of the C
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Figure 1.3 - Mechanisms from SCN to
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1.9.7 Melatonin and Clock Melatonin
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The links between the central clock
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Chapter 2 Methods
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There were strict inclusion and exc
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This personal contact on the postna
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2.1.3 Home monitoring visits The fi
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2.1.4 Further monitoring informatio
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Core body temperature was taken sim
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2.3 Collection of urine samples Pai
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were read against air at 429 nm aft
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allowed the display and comprehensi
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2.8.1 RNA preparation and cDNA synt
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In total three methods were trialle
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2.11 Statistical methods For compar
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test that each infant‟s height an
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Power calculation Sample size: Fift
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3 Results 3.1 Recruited subjects an
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predominantly affluent areas of the
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Birth history and past medical hist
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3.1.3 Socioeconomic demographics of
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Summary: 1. A mature physiological
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10 Results 10.1 Circadian rhythms -
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value of above 0.5 for R squared wa
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Table 10.1 - Temporal relationship
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Chapter 11 Discussion
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� What if any are the factors whi
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11.1 Physiological development - ag
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There are other proven factors whic
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drawbacks of the spread of data - a
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presented in table 6.1 do not have
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separate methods were applied to th
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significant. Sleep latency was cons
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The function of sleep in developmen
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Melatonin secretion was higher on n
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In this study sleeping in the same
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Timing of sleep maturation was diff
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systematic, ordered developmental p
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individual gene plots that provide
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temperature recording devices adapt
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Both melatonin and cortisol rhythms
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Extension of this period of monitor
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Second, we demonstrated the gene of
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Cortisol and melatonin Slope based
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Summary and Future work This study
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� Maximise technique for measurin
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“There is a science of infant car
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References
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Bajanowski, T., Vege, Å., Byard, R
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Chamley, C.A., Carson P, Randall D,
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Frank, M.G., Heller, H.C., 2003. Th
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intrahypothalamic administration of
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Mirmiran, M. & Ariagno, R.L., 2000.
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Rawson, D., Petersen, S.A., Wailoo,
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Stokkan, K.A., Yamazaki, S., Tei, H
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Winter, J.S.D., 1985. The adrenal c