ZMBH J.Bericht 2000 - Zentrum für Molekulare Biologie der ...

Multhaup, G., Hesse, L., Borchardt, T., Ruppert, T.,
Cappai, R., Masters, C.L. and Beyreuther, K. (1999).
Autoxidation of amyloid precursor protein and formation
of reactive oxygen species. In Copper Transport
and Its Disorders: Molecular and Cellular Aspects,
16, 183-192 (A. Leone and JFB Mercer, eds) Plenum,
New York.
Egensperger, R., Weggen, S., Ida, N., Multhaup, G.,
Schnabel, R., Beyreuther, K., and Bayer, T. A. (1999).
Reverse relationship between beta-amyloid precursor
protein and beta-amyloid peptide plaques in Down‘s
syndrome versus sporadic/familial Alzheimer‘s disease.
Acta Neuropathol. (Berl) 97, 113-8.
Multhaup, G., and Masters, C. L. (1999). Metal binding
and radical generation of proteins in human neurological
diseases and aging. Met. Ions Biol. Syst. 36,
365-87.
Lichtenthaler, S. F., Multhaup, G., Masters, C. L., and
Beyreuther, K. (1999). A novel substrate for analyzing
Alzheimer‘s disease gamma-secretase. FEBS Lett.
453, 288-92.
White, A.R., Reyes, R., Mercer, J.F.B., Camakaris, J.,
Zheng, H., Bush, A.I., Multhaup, G., Beyreuther, K.,
Masters, C.L. and Cappai, R. (1999). Copper levels
are increased in the cerebral cortex and liver of APP
and APLP2 knockout mice. Brain Res. 842, 439-444.
Bayer, T. A., Cappai, R., Masters, C. L., Beyreuther,
K., and Multhaup, G. (1999). It all sticks together - the
APP-related family of proteins and Alzheimer‘s disease.
Mol. Psychiatry 4, 524-528.
Borchardt, T., Camakaris, J., Cappai, R., Masters, C.
46
L., Beyreuther, K., and Multhaup, G. (1999). Copper
inhibits ß-amyloid production and stimulates the nonamyloidogenic
pathway of amyloid precursor protein
(APP) secretion. Biochem. J. 344, 461-467.
White, A. R., Multhaup, G., Maher, F., Bellingham,
S., Camakaris, J., Zheng, H., Bush, A. I., Beyreuther,
K., Masters, C. L., and Cappai, R. (1999). The
Alzheimer‘s disease amyloid precursor protein (APP)
modulates copper-induced toxicity and oxidative
stress in primary neuronal cultures. J. Neurosci. 19,
9170-9179.
Huang, X., Cuajungco, M.P., Atwood, C.S., Hartshorn,
M.A., Tyndall, J.D.A., Hanson, G.R., Stokes,
K.C., Leopold, M., Multhaup, G., Goldstein, L.E.,
Scarpa, R.C., Saunders, A.J., James Lim, Moir, R.D.,
Glabe, C., Bowden, E.F., Masters, C.L., Fairlie, D.P.,
Tanzi, R.E., and Bush, A.I. (1999). Cu(II) potentiation
of Alzheimer Aß neurotoxicity. Correlation with cellfree
hydrogen peroxide production and metal reduction.
J. Biol. Chem. 274, 3711-6.
Urban, S., Schwarz, C., Marx, U., Zentgraf, W. and
Multhaup, G. (2000). Receptor recognition by a hepatitis
B virus reveals a novel mode of high affinity
virus-host interaction. EMBO J. 19, 1217-1227.
Kulic, L., Walter, J., Multhaup, G., Teplow, D.B.,
Romig, H., Capell, A., Steiner, H. and Haass, C.
(2000). Separation of presenilin function in endoproteolysis
of the ß-amyloid precursor protein and notch.
Proc. Natl. Acad. Sci. USA, 97, 5913-5918.
Borchardt, T., Schmidt, C., Camakaris, J., Cappai,
R., Masters, C.L., Beyreuther, K. and Multhaup, G.
(2000). Differential effects of zinc on amyloid precur-
sor protein (APP) processing in copper-resistant variants
of cultured Chinese hamster ovary cells. Cell.
Mol. Biol, 46, 785-795.
Capell, A., Steiner, H., Willem, M., Kaiser, H., Meyer,
C., Walter, J., Lammich, S., Multhaup, G. and Haass,
C. (2000). Maturation and pro-peptide cleavage of
ß-secretase (BACE). J Biol Chem, (in press).
THESES
Dissertation
Hesse, Lars (1998): Funktionelle Analyse von extrazellulären
Domänen des Alzheimer Vorläuferproteins
und anderer Mitglieder der APP-Genfamilie.
Awards
1998 ‚Award‘ der ‚International Copper Association‘
(ICA)
1999 Alzheimer Forschung Initiative (AFI) ‚Grant
award‘
STRUCTURE OF THE GROUP
E-mail: g.multhaup@zmbh.uni-heidelberg.de
Group leader Multhaup, Gerd, Priv.-
Doz. Dr.
Research associate Strausak. Daniel, Dr.*
Postdoctoral fellows Hesse, Lars, Dr.*
Schmidt, Carsten, Dr.*
Ph.D. students Simons, Andreas*
Strauss, Markus*
Elle, Christine
Techn. assistant Schlicksupp, Andrea
*part of the time reported
47