ZMBH J.Bericht 2000 - Zentrum für Molekulare Biologie der ...

External Funding
During the period reported our research was supported
by grants from the Deutsche Forschungsgemeinschaft
(SFB 352 “Molekulare Mechanismen intrazellulärer
Transportprozesse”, DFG-Schwerpunkt “Funktionelle
Architektur des Zellkerns”, Graduiertenkolleg
“Molekulare Zellbiologie”), from the Human Frontier
Science Programme Organization and from the Fonds
der Chemischen Industrie.
PUBLICATIONS
Kutay, U., Lipowski, G., Izaurralde, E., Bischoff,
F.R., Schwarzmaier, P, Hartmann, E., and Görlich,
D. (1998). Identification of a tRNA-specific nuclear
export receptor. Mol. Cell. 1, 359-369.
Görlich, D. (1998). Transport into and out of the cell
nucleus (review). EMBO J. 17, 2721-2727.
Jäkel, S., and Görlich, D. (1998). Importin β, transportin,
RanBP5 and RanBP7 mediate nuclear import of
ribosomal proteins in mammalian cells. EMBO J. 17,
4491-4502.
Ribbeck, K., Lipowsky, G., Kent, H.M., Stewart, M.,
and Görlich, D. (1998). NTF2 mediates nuclear import
of Ran. EMBO J. 17, 6587-6598.
Ribbeck, K., Kutay, U., Paraskeva, E. and Görlich, D.
(1999). The translocation of transportin-cargo complexes
through nuclear pores is independent of Ran
and energy. Curr. Biol. 9, 47-50.
Lipowsky, G., Bischoff, F.R., Izaurralde, E., Kutay,
U., Schäfer, S. Gross, H.J., Hildburg Beier, H. and
Görlich, D. (1999). Coordination of tRNA nuclear
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export with processing of tRNA. RNA 5, 539-549.
Ziemienowicz, A., Görlich, D., Lanka, E., Hohn, B.,
and Rossi, L. (1999). Import of DNA into mammalian
nuclei by proteins originating from a plant pathogenic
bacterium. Proc. Natl. Acad. Sci. USA 96, 3729-33.
Jäkel, S., Albig, W., Schwamborn, K., Doenecke, D.,
and Görlich, D. (1999). The importinβ/ importin7 heterodimer
is a functional nuclear import receptor for
histone H1. EMBO J. 18, 2411-2423.
Paraskeva, E., Izaurralde, E., Bischoff, F.R., Huber, J.,
Kutay, U., Hartmann, E., Lührmann, R., and Görlich,
D. (1999). Crm1p-mediated recycling of snurportin 1
to the cytoplasm. J. Cell Biol. 145, 255-264.
Görlich, D. and Kutay, U. (1999). Transport between
the cell nucleus and the cytoplasm. Annu. Rev. Cell
Dev. Biol. 15, 607-660.
Vetter, I.R., Arndt, A. Kutay, U., Görlich, D. and
Wittinghofer, A (1999). Structural view of the Ran-
Importin β interaction at 2.3 Å resolution. Cell 97,
635-646.
Jullien, D., Görlich, D., Laemmli, U.K., and Adachi,
Y (1999). Nuclear import of RPA in Xenopus egg
extracts requires a novel protein XRIPα but not importin
α. EMBO J. 18, 4348-4358.
Bayliss, R., Ribbeck, K., Akin, D., Kent, H.M., Feldherr,
C.M., Görlich, D., and Stewart, M. (1999).
Interaction between NTF2 and xFxFG-containing
nucleoporins is required to mediate nuclear import of
RanGDP. J. Mol. Biol. 293, 579-93.
Köhler, M., Speck, C., Christiansen, M., Bischoff,
F.R., Prehn, S., Haller, H., Görlich, D., and Hartmann,
E. (1999). Evidence for distinct substrate specificities
of importin alpha family members in nuclear protein
import. Mol. Cell. Biol. 19, 7782-91.
Bachi, A, Braun, I.C., Rodrigues, J.P., Pante, N.,
Ribbeck, K., von Kobbe, C., Kutay, U., Wilm, M.,
Görlich, D., Carmo-Fonseca, M., and Izaurralde, E.
(2000). The C-terminal domain of TAP interacts with
the nuclear pore complex and promotes export of
specific CTE-bearing RNA substrates. RNA J., (in
press).
Bannister, A.J., Miska, E.A., Görlich, D. and Kouzarides,
T. (2000). Acetylation of importin α nuclear
import factors by CBP/p300. Curr. Biol. 10, 467-470.
Lipowsky, G., Bischoff, F.R., Schwarzmaier, P., Kraft,
R., Hartmann, E., Kutay, U., and Görlich, D. (2000).
Exportin 4: a mediator of a novel nuclear export pathway
in higher eukaryotes. EMBO J., (in press).
STRUCTURE OF THE GROUP
E-mail: dg@zmbh.uni-heidelberg.de (Dirk Görlich)
Group leader Görlich, Dirk, Dr.
Postdoctoral
fellows Kutay, Ulrike, Dr. *
Paraskeva, Froso, Dr.
Dean, Kelly, Dr.*
Mingot, José-Manuel, Dr. *
Ph.D. students Lipowsky, Gerd, Dipl. Biol.
Jäckel, Stefan, Dipl. Biol.
Ribbeck, Katharina, Dipl. Biol.
Technical assistant Schwarzmaier, Petra
* part of the time reported
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