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70<br />

STABILITY Investigators. The ABC (age, biomarkers, clinical history) stroke risk<br />

score: a biomarker-based risk score for predicting stroke in atrial fibrillation. Eur<br />

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383. Gage BF, Yan Y, Milligan PE,Waterman AD, Culverhouse R, RichMW, Radford MJ.<br />

Clinical classification schemes for predicting hemorrhage: results from the<br />

National Registry of Atrial Fibrillation (NRAF). Am Heart J. 2006;151:713–9.<br />

384. Pisters R, Lane DA, Nieuwlaat R, de Vos CB, Crijns HJ, Lip GY. A novel userfriendly<br />

score (HAS-BLED) to assess 1-year risk of major bleeding in patients with atrial<br />

fibrillation: the Euro Heart Survey. Chest. 2010;138:1093–100.<br />

385. Fang MC, Go AS, Chang Y, Borowsky LH, Pomernacki NK, Udaltsova N, Singer DE.<br />

A new risk scheme to predict warfarin-associated hemorrhage: The ATRIA<br />

(Anticoagulation and Risk Factors in Atrial Fibrillation) Study. J Am Coll Cardiol.<br />

2011;58:395–401.<br />

386. Friberg L, Rosenqvist M, Lip GY. Evaluation of risk stratification schemes for<br />

ischaemic stroke and bleeding in 182 678 patients with atrial fibrillation: the<br />

Swedish Atrial Fibrillation cohort study. Eur Heart J. 2012;33:1500–10.<br />

387. Hijazi Z, Oldgren J, Lindback J, Alexander JH, Connolly SJ, Eikelboom JW, Ezekowitz<br />

MD, Held C, Hylek EM, Lopes RD, Siegbahn A, Yusuf S, Granger CB, Wallentin L,<br />

ARISTOTLE and RE-LY Investigators. The novel biomarker-based ABC (age,<br />

biomarkers, clinical history)-bleeding risk score for patients with atrial<br />

fibrillation: a derivation and validation study. Lancet. 2016;387:2302–11.<br />

388. O’Brien EC, Simon DN, Thomas LE, Hylek EM, Gersh BJ, Ansell JE, Kowey PR,<br />

Mahaffey KW, Chang P, Fonarow GC, Pencina MJ, Piccini JP, Peterson ED. The<br />

ORBIT bleeding score: a simple bedside score to assess bleeding risk in atrial<br />

fibrillation. Eur Heart J. 2015;36:3258–64.<br />

389. Loewen P, Dahri K. Risk of bleeding with oral anticoagulants: an updated<br />

systematic review and performance analysis of clinical prediction rules. Ann<br />

Hematol. 2011;90:1191–200.<br />

390. Olesen JB, Lip GY, Hansen PR, Lindhardsen J, Ahlehoff O, Andersson C,Weeke P,<br />

Hansen ML, Gislason GH, Torp-Pedersen C. Bleeding risk in ‘real world’ patients<br />

with atrial fibrillation: comparison of two established bleeding prediction<br />

schemes in a nationwide cohort. J Thromb Haemost. 2011;9:1460–7.<br />

391. Van Staa TP, Setakis E, Di Tanna GL, Lane DA, Lip GY. A comparison of risk<br />

stratification schemes for stroke in 79,884 atrial fibrillation patients in general<br />

practice. J Thromb Haemost. 2011;9:39–48.<br />

392. Roldan V, Marin F, Manzano-Fernandez S, Gallego P, Vilchez JA, Valdes M, Vicente<br />

V, Lip GY. The HAS-BLED score has better prediction accuracy for major bleeding<br />

than CHADS2 or CHA2DS2-VASc scores in anticoagulated patients with atrial<br />

fibrillation. J Am Coll Cardiol. 2013;62:2199–204.<br />

393. Wallentin L, Hijazi Z, Andersson U, Alexander JH, De Caterina R, Hanna M,<br />

Horowitz JD, Hylek EM, Lopes RD, Asberg S, Granger CB, Siegbahn A, ARISTOTLE<br />

Investigators. Growth differentiation factor 15, a marker of oxidative stress and<br />

inflammation, for risk assessment in patients with atrial fibrillation: insights<br />

from the Apixaban for Reduction in Stroke and Other Thromboembolic Events in<br />

Atrial Fibrillation (ARISTOTLE) trial. Circulation. 2014;130:1847–58.<br />

394. Raunso J, Selmer C, Olesen JB, Charlot MG, Olsen AM, Bretler DM, Nielsen JD,<br />

Dominguez H, Gadsboll N, Kober L, Gislason GH, Torp-Pedersen C, Hansen ML.<br />

Increased short-term risk of thrombo-embolism or death after interruption of<br />

warfarin treatment in patients with atrial fibrillation. Eur Heart J. 2012;33:<br />

1886–92.<br />

395. Sjogren V, Grzymala-Lubanski B, Renlund H, Friberg L, Lip GY, Svensson PJ,<br />

Sjalander A. Safety and efficacy of well managed warfarin. A report from the<br />

Swedish quality register Auricula. Thromb Haemost. 2015;113:1370–7.<br />

396. Graham DJ, Reichman ME,Wernecke M, Zhang R, Southworth MR, Levenson M,<br />

Sheu TC, Mott K, Goulding MR, Houstoun M, MaCurdy TE,Worrall C, Kelman JA.<br />

Cardiovascular, bleeding, and mortality risks in elderly medicare patients treated<br />

with dabigatran or warfarin for nonvalvular atrial fibrillation. Circulation.<br />

2015;131:157–64.<br />

397. Apostolakis S, Sullivan RM, Olshansky B, Lip GY. Factors affecting quality of<br />

anticoagulation control among patients with atrial fibrillation on warfarin: the<br />

SAMe-TT(2)R(2) score. Chest. 2013;144:1555–63.<br />

398. Lip GY, Haguenoer K, Saint-Etienne C, Fauchier L. Relationship of the SAMe-TT(2)<br />

R(2) score to poor-quality anticoagulation, stroke, clinically relevant bleeding,<br />

and mortality in patients with atrial fibrillation. Chest. 2014;146:719–26.<br />

399. Gallego P, Roldan V, Marin F, Galvez J, Valdes M, Vicente V, Lip GY. SAMe-TT2R2<br />

score, time in therapeutic range, and outcomes in anticoagulated patients with<br />

atrial fibrillation. Am J Med. 2014;127:1083–8.<br />

400. Eikelboom JW, Connolly SJ, Brueckmann M, Granger CB, Kappetein AP, Mack MJ,<br />

Blatchford J, Devenny K, Friedman J, Guiver K, Harper R, Khder Y, Lobmeyer MT,<br />

Maas H, Voigt JU, Simoons ML, Van deWerf F, RE-ALIGN Investigators. Dabigatran<br />

versus warfarin in patients with mechanical heart valves. N Engl J Med.<br />

2013;369:1206–14.<br />

401. Olesen JB, Sorensen R, Hansen ML, Lamberts M,Weeke P, Mikkelsen AP, Kober L,<br />

Gislason GH, Torp-Pedersen C, Fosbol EL. Non-vitamin K antagonist oral<br />

anticoagulation agents in anticoagulant naive atrial fibrillation patients: Danish<br />

nationwide descriptive data 2011–2013. Europace. 2015;17:187–93.<br />

402. Hylek EM, Held C, Alexander JH, Lopes RD, De Caterina R, Wojdyla DM, Huber K,<br />

Jansky P, Steg PG, Hanna M, Thomas L,Wallentin L, Granger CB. Major bleeding in<br />

patients with atrial fibrillation receiving apixaban or warfarin: The ARISTOTLE<br />

Trial (Apixaban for Reduction in Stroke and Other Thromboembolic Events in<br />

Atrial Fibrillation): Predictors, Characteristics, and Clinical Outcomes. J Am Coll<br />

Cardiol. 2014;63:2141–7.<br />

403. Flaker GC, Eikelboom JW, Shestakovska O, Connolly SJ, Kaatz S, Budaj A, Husted<br />

S, Yusuf S, Lip GY, Hart RG. Bleeding during treatment with aspirin versus<br />

apixaban in patients with atrial fibrillation unsuitable for warfarin: the apixaban<br />

versus acetylsalicylic acid to prevent stroke in atrial fibrillation patients who<br />

have failed or are unsuitable for vitamin K antagonist treatment (AVERROES)<br />

trial. Stroke. 2012;43:3291–7.<br />

404. Connolly SJ, Ezekowitz MD, Yusuf S, Reilly PA, Wallentin L, Randomized<br />

Evaluation of Long-Term Anticoagulation Therapy Investigators. Newly identified<br />

events in the RE-LY trial. N Engl J Med. 2010;363:1875–6.<br />

405. Ruff CT, Giugliano RP, Braunwald E, Morrow DA, Murphy SA, Kuder JF, Deenadayalu<br />

N, Jarolim P, Betcher J, Shi M, Brown K, Patel I, Mercuri M, Antman EM. Association<br />

between edoxaban dose, concentration, anti-Factor Xa activity, and outcomes: an<br />

analysis of data from the randomised, double-blind ENGAGE AF-TIMI 48 trial.<br />

Lancet. 2015;385:2288–95.<br />

406. Beyer-Westendorf J, Forster K, Pannach S, Ebertz F, Gelbricht V, Thieme C,<br />

Michalski F, Kohler C, Werth S, Sahin K, Tittl L, Hansel U, Weiss N. Rates,<br />

management, and outcome of rivaroxaban bleeding in daily care: results from<br />

the Dresden NOAC registry. Blood. 2014;124:955–62.<br />

407. Camm AJ, Amarenco P, Haas S, Hess S, Kirchhof P, Kuhls S, van Eickels M, Turpie<br />

AG, XANTUS Investigators. XANTUS: a real-world, prospective, observational<br />

study of patients treated with rivaroxaban for stroke prevention in atrial<br />

fibrillation. Eur Heart J. 2016;37:1145–53.<br />

408. Wallentin L, Yusuf S, Ezekowitz MD, Alings M, Flather M, Franzosi MG, Pais P,<br />

Dans A, Eikelboom J, Oldgren J, Pogue J, Reilly PA, Yang S, Connolly SJ, RE-LY<br />

investigators. Efficacy and safety of dabigatran compared with warfarin at<br />

different levels of international normalised ratio control for stroke prevention in<br />

atrial fibrillation: an analysis of the RE-LY trial. Lancet. 2010;376:975–83.<br />

409. Piccini JP, Hellkamp AS, Lokhnygina Y, Patel MR, Harrell FE, Singer DE, Becker RC,<br />

Breithardt G, Halperin JL, Hankey GJ, Berkowitz SD, Nessel CC, Mahaffey KW, Fox<br />

KA, Califf RM, ROCKET AF Investigators. Relationship between time in therapeutic<br />

range and comparative treatment effect of rivaroxaban and warfarin: results<br />

from the ROCKET AF trial. J Am Heart Assoc. 2014;3:e000521.<br />

410. Olesen JB, Lip GY, Kamper AL, Hommel K, Kober L, Lane DA, Lindhardsen J,<br />

Gislason GH, Torp-Pedersen C. Stroke and bleeding in atrial fibrillation with<br />

chronic kidney disease. N Engl J Med. 2012;367:625–35.<br />

411. Albertsen IE, Rasmussen LH, Overvad TF, Graungaard T, Larsen TB, Lip GY. Risk of<br />

stroke or systemic embolism in atrial fibrillation patients treated with warfarin:<br />

A systematic review and meta-analysis. Stroke. 2013;44:1329–36.<br />

412. Hart RG, Pearce LA, Asinger RW, Herzog CA. Warfarin in atrial fibrillation<br />

patients with moderate chronic kidney disease. Clin J Am Soc Nephrol. 2011;6:<br />

2599–604.<br />

413. Friberg L, Benson L, Lip GY. Balancing stroke and bleeding risks in patients with<br />

atrial fibrillation and renal failure: the Swedish Atrial Fibrillation Cohort study.<br />

Eur Heart J. 2014:36:297–306.<br />

414. Jun M, James MT, Manns BJ, Quinn RR, Ravani P, Tonelli M, Perkovic V,<br />

Winkelmayer WC, Ma Z, Hemmelgarn BR. The association between kidney<br />

function and major bleeding in older adults with atrial fibrillation starting<br />

warfarin treatment: population based observational study. BMJ. 2015;<br />

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415. Del-Carpio Munoz F, Gharacholou SM, Munger TM, Friedman PA, Asirvatham SJ,<br />

Packer DL, Noseworthy PA. Meta-Analysis of Renal Function on the Safety and<br />

Efficacy of Novel Oral Anticoagulants for Atrial Fibrillation. Am J Cardiol.<br />

2016;117:69–75.<br />

416. Heidbuchel H, Verhamme P, Alings M, Antz M, Diener HC, HackeW, Oldgren J,<br />

Sinnaeve P, Camm AJ, Kirchhof P. Updated European Heart Rhythm Association<br />

Practical Guide on the use of non-vitamin K antagonist anticoagulants in patients<br />

with non-valvular atrial fibrillation. Europace. 2015;17:1467–507.<br />

417. Zimmerman D, Sood MM, Rigatto C, Holden RM, Hiremath S, Clase CM. Systematic<br />

review and meta-analysis of incidence, prevalence and outcomes of atrial<br />

fibrillation in patients on dialysis. Nephrol Dial Transplant. 2012;27:3816–22.<br />

418. Marinigh R, Lane DA, Lip GY. Severe renal impairment and stroke prevention in<br />

atrial fibrillation: implications for thromboprophylaxis and bleeding risk. J Am<br />

Coll Cardiol. 2011;57:1339–48.<br />

419. Wizemann V, Tong L, Satayathum S, Disney A, Akiba T, Fissell RB, Kerr PG, Young<br />

EW, Robinson BM. Atrial fibrillation in hemodialysis patients: clinical features<br />

and associations with anticoagulant therapy. Kidney Int. 2010;77:1098–106.<br />

420. Chan KE, Lazarus JM, Thadhani R, Hakim RM. Warfarin use associates with<br />

increased risk for stroke in hemodialysis patients with atrial fibrillation. J Am Soc<br />

Nephrol. 2009;20:2223–2233.<br />

421. Winkelmayer WC, Liu J, Setoguchi S, Choudhry NK. Effectiveness and safety of<br />

warfarin initiation in older hemodialysis patients with incident atrial fibrillation.<br />

Clin J Am Soc Nephrol 2011;6:2662–2668.<br />

422. Shah M, Avgil Tsadok M, Jackevicius CA, Essebag V, Eisenberg MJ, Rahme E,<br />

Humphries KH, Tu JV, Behlouli H, Guo H, Pilote L. Warfarin use and the risk for<br />

stroke and bleeding in patients with atrial fibrillation undergoing dialysis.<br />

Circulation. 2014;129:1196–203.<br />

423. Bonde AN, Lip GY, Kamper AL, Hansen PR, Lamberts M, Hommel K, Hansen ML,<br />

Gislason GH, Torp-Pedersen C, Olesen JB. Net clinical benefit of antithrombotic<br />

therapy in patients with atrial fibrillation and chronic kidney disease:<br />

a nationwide observational cohort study. J Am Coll Cardiol. 2014;64:2471–82.<br />

424. Chan KE, Edelman ER, Wenger JB, Thadhani RI, Maddux FW. Dabigatran and<br />

rivaroxaban use in atrial fibrillation patients on hemodialysis. Circulation.<br />

2015;131:972–79.<br />

425. Hijazi Z, Hohnloser SH, Oldgren J, Andersson U, Connolly SJ, Eikelboom JW,<br />

Ezekowitz MD, Reilly PA, Siegbahn A, Yusuf S, Wallentin L. Efficacy and safety of<br />

dabigatran compared with warfarin in relation to baseline renal function in<br />

patients with atrial fibrillation: a RE-LY (Randomized Evaluation of Long-term<br />

Anticoagulation Therapy) trial analysis. Circulation. 2014;129:961–70.<br />

426. Fox KA, Piccini JP, Wojdyla D, Becker RC, Halperin JL, Nessel CC, Paolini JF, Hankey<br />

GJ, Mahaffey KW, Patel MR, Singer DE, Califf RM. Prevention of stroke and

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