Conduct disorder

Novini vo pedijatrijata / Godi[na revija 2009
TERAPIJA SO HELATORI NA @ELEZO KAJ
DECA SO TRANSFUZIONO ZAVISNI ANEMII
Kata Martinova
Klinika za detski bolesti
Oddel za detska hematologija i onkologija
REZIME
Terapijata so helatori na `elezo pretstavuva va`en del vo tretmanot na
pacientite koi [to primaat transfuzii na crveni krvni elementi kako pomo[na
terapija za hroni~ni anemii kako [to se beta-talasemija, anemija so
srpesti eritrociti (SCD) i mielodisplasti~ni sindromi (MDS). Preoptovaruvaweto
so `elezo koe nastanuva kako posledica na povtoruva~ki
transfuzii na crveni krvni elementi ili na zgolemena apsorpcija na
`elezo vneseno so hranata doveduva do progresivna disfunkcija na organite
pred sé na srceto, crniot drob i na endokrinite `lezdi i ima seriozno
vlijanie na morbiditetot i mortalitetot. Se o~ekuva deka novite metodi
za merewe na tkivnoto preoptovaruvawe so `elezo, novite lekovi za
eliminacija na vi[okot na `elezo i novite protokoli za helacija na `elezoto
]e imaat golemo vlijanie vo tretmanot na sostojbite koi [to se povrzani
so preoptovaruwe so `elezo. Helatorite na `elezo treba da bidat
bezbedni, efikasni i kompatibilni so kvaliteten `ivot.
ABSTRACT
Iron chelation therapy forms an important part of treatment for patients receiving
red blood cell transfusions as supportive therapy for chronic anemias such as Beta –
thalassemia, sicle cell disease (SCD) and the myelodisplastic syndromes (MDS). Iron
overload as a consequence of repeated red blood cell transfusions or of increased
absorption of dietary iron results in progressive dysfunction of the heart, liver and
endocrine glands and has a serious impact on morbidity and mortality. New
methods for measuring tissue iron overload, new drugs to remove excess iron and
new regimens of chelation are expected to have a major impact on the management
of conditions associated with iron overload. Iron chelation should be safe, effective
and compatible with a good quality of life.
Voved
Preoptovaruvaweto so `elezo e predvidliva i `ivotno zagrozuva~ka komplikacija
kaj pacienti so talasemija i drugi hematolo[ki poremetuvawa
(disfunkionalni bolesti na koskenata srcevina i retki kongenitalni anemii)
~ij uspe[en tretman zavisi od regularni transfuzii na crveni krvni
elementi. Vo otsustvo na efikasna helatorna terapija za `elezo hroni~nite
transfuzii predizvikuvaat akumulacija na `elezo vo crniot drob,
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