Ressortforschungsberichte zur kerntechnischen Sicherheit und zum ...

Tabelle 9-3: Studien zu therapeutischer Exposition mit ionisierender Strahlung und der Entstehung von Katarakt, Teil I
Reference:
First author (year)
Area of
study
Type of study Diagnosis of patients treated
with ionising radiation
Treatment of malignant neoplasms of eye and adnexa and of brain
COMS group, 2004
and 2007
USA, multicentric
Kivela et al., 2003 Finland (IBT)
and U.K.
(TSR)
Marcus et al., 2001 Georgia,
USA
Gunduz et al., 1999 Philadelphia,
USA
Shields et al., 2006 Philadelphia,
USA
RCT
Case control
study
Number
irradiated
patients
Choroidal melanoma n=649 Same diagnosis, but
enucleation therapy
Choroidal melanoma
RCT Subfoveal choroidal
neovascularization in agerelated
macular degeneration
Cohort study
/case series
Control group definition Number nonirradiated
controls
n=49 Same diagnosis, but
transscleral resection (TSR)
n=41 Same diagnosis, but
observation
– 111 –
Recruitment
period
Follow-up
period
Type of ionising radiation
applied in irradiated group
(as given in the paper)
n=647 1987-1998 Until 2003 I-125 brachytherapy (IBT)
n=49 1990-1998 (IBT)
1988-1998
(TSR)
n=42 1995-1998 Up to 4
years
3 – 6 years IBT
External beam irradiation by 6-
MV photon beam described in
detail
Choroidal melanoma n=630 - - 1976-1992 10 years Plaque radiotherapy (I-125,
Ru-106, Co-60, Irid-192)
Cohort study Retinoblastoma recurrence in
patients after chemoreduction
Punyko et al., 2005 USA Cohort study Rhabdomyosarcoma survivors
(part of the Childhood Cancer
Survivor Study)
Raney et al., 2000 USA, multicentric
Puusaari et al, 2004
and 2005
Puusaari et al. 2007 Finland (IBT)
and U.K.
(TSR)
Summanen et al.,
1996
Gragoudas et al.,
1995
Cohort study Localized primary rhabdomyosarcoma
of the orbit
Finland Cohort study Uveal melanoma
Case control
study
Uveal melanoma
Finland Cohort study Uveal melanoma
Cambridge,
USA
Meecham et al., 1994 San
Francisco,
USA
n=64
(71 eyes)
- - 1994-2005 Up to 15
years
n=606 Siblings n=3,701 1970-1986
n=79 - - 1984-1991
Range:
5.2–28.8
years
Median:
7.4 years
n=96 - - 1990-2001 Median:
3.5 years
n=54 Same diagnosis, but TSR n=33 1990-2003 Median:
2.3 years
(TSR), and
5.3 (IBT)
n=99 - - 1981-1991 Median:
2.8 years
Cohort study Uveal melanoma n=383 - - 1987-1989 Until June
1992
Cohort study Uveal melanoma n=292 - - Until May 1991 Mean:
5.0 years
Plaque radiotherapy (I-125)
Not specified
XRT megavoltage equipment.
IBT
IBT
Ruthenium plaque
radiotherapy
Proton irradiation (external
beam)
Helium ion irradation
(tantalum marker rings)