Ressortforschungsberichte zur kerntechnischen Sicherheit und zum ...

Reference:
First author (year)
Area of
study
Type of study Diagnosis of patients treated
with ionising radiation
Michel et al., 1997 France Cohort study Leukaemia (AML)
Benyunes et al., 1995 Seattle, USA Cohort study BMT in aplastic anaemia,
leukaemia, lymphoma and
other diagnoses
Tichelli et al., 1993
and 1994
Calissendorff et al.,
1993
Dunn et al., 1993 Baltimore
and Atlanta,
USA
Ozsahin et al., 1992
and 1994
Switzer-land Prospective
controlled
cohort study
Sweden Prospective
cohort study
Case control
study
BMT in aplastic anaemia,
leukaemia, lymphoma and
other diagnoses
BMT in leukaemia, severe
aplastic anaemia, and other
diagnoses
BMT in aplastic anaemia,
leukaemia, lymphoma and
other diagnoses (in four
treatment groups); n=40 cases
with cataract
France Cohort study BMT in leukaemia, lymphoma,
Non-Hodgkin
lymphoma, multiple myeloma
and other diagnoses;
Bray et al. 1991 UK Cohort study BMT in various haematological
malignancies
Van Weel-Sipman et
al., 1990
Nether-lands Cohort study Hematological malignancy
Livesey et al., 1989 UK Comparative
clinical study
BMT in leukaemia and
aplastic anaemia
Number
irradiated
patients
n=19
irradiated
n=407 treated
with TBI and
chemotherapy
Control group definition Number nonirradiated
controls
Same diagnosis, but nonirradiated
Same diagnosis, but
only conditioned with
chemotherapy
n=164 Same diagnosis, but
only conditioned with
chemotherapy
n=43
leukaemia pat.
condit. with
TBI and
chemotherapy
other
assignment
Patients with severe aplastic
anaemia conditioned only
with chemotherapy
Same diagnosis, cataractfree
controls; n=326
– 114 –
Recruitment
period
Follow-up
period
n=26 1986-1992 Mean
follow-up
5.9 years
n=85 Not stated Median: 6
years
(range 2-
18)
n=33 1979-1991 At least
180 days
n=9
other
assignment
1978-1989
Median: 5
years
(range 1-
10)
1978-1991 Until June
1992
n=157 - - Recruited 1986-
1989
n=30 treated
with TBI
n=27
survivors
Same diagnosis, but nonirradiated
Until July
1992
n=11 1983-1989 6-84
months
- - 1980-1988 Up to 8
years
n=27 Same diagnosis and one
non-Hodgkin lymphoma,
but non-irradiated
n=7 1983-1988 5-63
months
Type of ionising radiation
applied in irradiated group
(as given in the paper)
TBI
TBI; dual opposing Co-60
sources
TBI with linear accelerator
TBI with linear accelerator at a
mean dose of 0.04 Gy/min.
TBI
Before 1989 6-MV X-ray
linear accelerator, then a
cobalt-60 telecobalt unit
Linear accelerator with midline
tissue dose rate of 0-25
Gy/min.
TBI with linear accelerator
TBI