Ressortforschungsberichte zur kerntechnischen Sicherheit und zum ...

Reference:
First author (year)
Type of ionising
radiation applied
in irradiated
group
Radiation dose regimen or
reconstructed total body
dose (TBD)
Aristei et al., 2002 TBI s-TBI: 8 Gy (range 7–8.5);
f-TBI: 3 or 2x/day Gy , total
14.4 Gy (range 12–15.6)
Beyzadeoglu et al., 2002 Cobalt-60
teletherapy machine
2 Gy f-TBI in 6 fractions over
3 consecutive days;
high-dose (> 0.04 Gy/min) vs.
low-dose group (< or = 0.04
Gy/min)
Zierhut et al., 2000 TBI f-TBI: median dose 14.4 Gy,
12 fractions on 4 consecutive
days; dose rate of 7–18
cGy/min
Frisk et al., 2000 TBI 7.5 Gy as single dose with a
midline dose rate of 0.15
Gy/min, only 1 patient with 6
fractions of 2 Gy
Ng et al., 1999 TBI 12 Gy f-TBI in 6 fractions over
3 consecutive days, dose rate
11 cGy/min
Belkacemi et al.,
June 1998
TBI s-TBI median dose 10 Gy; f-
TBI median dose 12 Gy in 2-
12 fractions (>50% with 6
fractions). Two dose rate
groups in s-TBI and f-TBI with
≤0.04 Gy/min and >0.04.
Lens dose (LD) Exposure assessment Outcome assessment
– 120 –
Risk estimates for cataract
Estimated cumulative
incidence (ECI),
or other results of
incidence
n.a. Medical records Slit- lamp biomicroscopy Cataracts in 14 of 107
(13%) f-TBI patients
and in 18 of 86 (21%)
s-TBI patients.
n.a. Medical records Not stated ECI at 10 years in
high-dose rate group
was 43 %; no cataracts
in low-dose rate
group. (PSC in 5 eyes
of 3 patients out of
n=46).
n.a. Medical records; measures
for homogeneity of
exposure performed
Ophthalmic examination Cataract occurred in
28 of 85 patients
(32.9%) after a median
of 47 months (1–104
months).
n.a. Medical records Slit- lamp biomicroscopy 100% of patients with
TBI developed a
posterior subcapsular
cataract, only 1 of 8 in
non-TBI group.
n.a. Medical records Complete ophthalmic
examination
Lens opacities in 2
(33.3%) of 6 irradiated
patients and 2 (8.7%)
of 23 nonirradiated
patients.
n.a. Medical records Ophthalmic examination 10-year ECI: 60% in
s-TBI, 43% in f-TBI
with 6
fractions (p < 0.001).
Comparative
analyses; risk ratio
(RR), or hazard
rate (HR)
sTBI vs f-TBI:
RR=7.2, p0.05).
-
-
ECI was lower with
low dose rate
groups (30%) than
in the higher (59%)
(p< 0.001).