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Dendritic Cell Vaccines for Gliomas 89 Figure 1 (See color insert.) Immunohistochemical characterization of infiltrating cells in intracranial tumor before and after DC vaccination: Intratumoral CD8 þ cells, pre- (A), and post-vaccination (B). Intratumoral CD4 þ cells, pre- (C), and post-vaccination (D). Intratumoral CD45RO þ cells, pre- (E), and post-vaccination (F). Intratumoral CD8 þ cells pre- (G) and post-recurrence (H) in a non-vaccinated patient. (2 patients) malignant glioma, including anaplastic astrocytoma and GBM, were given three vaccinations with autologous DC pulsed with autologous tumor lysate every other week over a six-week period. In four out of nine patients, as part of an HLA-restricted tetramer staining assay, it was found that there were one or more tumor-associated antigen (TAA)-specific CTL clones against melanoma antigen-encoding gene-1, gp100, and human epidermal growth factor receptor (HER)-2 (Fig. 2). DC vaccination offered a significant survival benefit
90 Luptrawan et al. Figure 2 Representative flow cytometry plots from a single glioma patient vaccinated with autologous tumor lysate pulsed DCs. PBMC isolated pre- (left column) and post-vaccination (right column) were stained with HLA restricted tetramers for HER-2, gp100, and MAGE-1 (y-axis). Additionally, cells were stained for the CD8 antigen (x-axis). Plots indicate a significant increase in the number of cells that registered as double positive (i.e. bound to antigen specific tetramers and positive for CD8). This demonstrates an expansion in the populations of CTL specific for these TAAs in this patient following DC vaccination.
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Translational Medicine Series 6 Can
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TRANSLATIONAL MEDICINE SERIES 1. Pr
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Informa Healthcare USA, Inc. 52 Van
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Preface Throughout the last 20 year
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Preface vii Table 1 A Diverse Techn
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Preface . . . . v Contributors . .
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Contributors Pedro Alves Ludwig Ins
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1 Factoring in Antigen Processing i
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Factoring in Antigen Processing in
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2 Outlining the Gap Between Preclin
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Preclinical Models and Clinical Sit
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Table 1 Examples of Preclinical Act
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Preclinical Models and Clinical Sit
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Multimodality Immunization Approach
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Figure 5.1 Immunohistochemical char
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Figure 8.5 A schematic representati
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8 Bidirectional Bedside Lab Bench P
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Development of Novel Immunotherapeu
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Diagnostic Approaches to Maximize T
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206 Index Antigenic peptides degrad
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208 Index Chromogens, enzymatic act
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210 Index Freund’s adjuvants. See
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212 Index Langerhans cells, 133, 13
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214 Index [Peptide vaccines] invest
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216 Index TCRL. See TCR-like immuno
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Oncology and Immunology about the b
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