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Table 1 Summary of results of phase I and phase II DC-based immunotherapy for malignant gliomas (Continued ) Intratumoral T cells postvaccination on reoperation Response postvaccination Target disease Vaccine Results Patient population Trial phase Senior investigator/ reference Dendritic Cell Vaccines for Gliomas 101 2 patients after reoperation after vaccination demonstrated intratumoral CD4 þ and CD8 þ T-cell infiltration Increased percentage of CD56 þ cells in PBL after vaccination 2 patients after vaccination had increase in T cells reactive against tumor lysate– pulsed DCs 3 patients after vaccination demonstrated only weak T-cell responses against tumor lysate– pulsed DCs DC-pulsed tumor lysate every 3 weeks for a minimum of one and maximum of 10 vaccinations injected intradermally close to a cervical lymph node and/or intratumorally via an Ommaya reservoir Recurrent HGG Phase I/II 10 (7 GBM, 3 AA) Yamanaka et al. (2003) (49) Those who received both intradermal and intratumoral administration (n ¼ 5) demonstrated a clinical response (Continued )
102 Luptrawan et al. Table 1 Summary of results of phase I and phase II DC-based immunotherapy for malignant gliomas (Continued ) Intratumoral T cells postvaccination on reoperation Response postvaccination Target disease Vaccine Results Patient population Trial phase Senior investigator/ reference T cells reactive against tumor lysate–pulsed DCs increased in 7 of 24 patients after vaccination GBM 480 days (study group) versus 400 days (control group) Longer survival in patients with matured DC administration Patients with both intradermal and intratumoral administration had longer survival Upon recurrence, phase I–immatured DC-pulsed tumor lysate intradermally or both intradermally and intratumorally (via Ommaya reservoir), Phase II–matured DC (matured with OK- 432)-pulsed tumor lysate intradermally administered and immature DC were intratumorally administered Recurrent HGG Phase I/II 24 (6 AA, 18 GBM) Phase I (n ¼ 17) Phase II (n ¼ 7) Yamanaka et al. (2005) (51) than with intradermal alone
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Translational Medicine Series 6 Can
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TRANSLATIONAL MEDICINE SERIES 1. Pr
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Informa Healthcare USA, Inc. 52 Van
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Preface Throughout the last 20 year
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Preface vii Table 1 A Diverse Techn
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Preface . . . . v Contributors . .
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Contributors Pedro Alves Ludwig Ins
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1 Factoring in Antigen Processing i
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Factoring in Antigen Processing in
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2 Outlining the Gap Between Preclin
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Preclinical Models and Clinical Sit
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Table 1 Examples of Preclinical Act
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Page 71 and 72: 56 Srinivasan disease agents. Garda
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Multimodality Immunization Approach
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Multimodality Immunization Approach
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8 Bidirectional Bedside Lab Bench P
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Development of Novel Immunotherapeu
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9 Diagnostic Approaches for Selecti
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Diagnostic Approaches to Maximize T
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206 Index Antigenic peptides degrad
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208 Index Chromogens, enzymatic act
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210 Index Freund’s adjuvants. See
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212 Index Langerhans cells, 133, 13
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214 Index [Peptide vaccines] invest
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216 Index TCRL. See TCR-like immuno
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Oncology and Immunology about the b
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