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Multimodality Immunization Approaches 147 23. Fu TM, Ulmer JB, Caulfield MJ, et al. Priming of cytotoxic T lymphocytes by DNA vaccines: requirement for professional antigen presenting cells and evidence for antigen transfer from myocytes. Mol Med 1997; 3:362–371. 24. Spetz AL, Sorensen AS, Walther-Jallow L, et al. Induction of HIV-1-specific immunity after vaccination with apoptotic HIV-1/murine leukemia virus-infected cells. J Immunol 2002; 169:5771–5779. 25. Srivastava P. Interaction of heat shock proteins with peptides and antigen presenting cells: chaperoning of the innate and adaptive immune responses. Annu Rev Immunol 2002; 20:395–425. 26. Locher CP, Witt SA, Ashlock BM, et al. Enhancement of antibody responses to an HIV-2 DNA envelope vaccine using an expression vector containing a constitutive transport element. DNA Cell Biol 2002; 21:581–586. 27. Bot A, Stan AC, Inaba K, et al. Dendritic cells at a DNA vaccination site express the encoded influenza nucleoprotein and prime MHC class I-restricted cytolytic lymphocytes upon adoptive transfer. Int Immunol 2000; 12:825–832. 28. Dean DA, Dean BS, Muller S, et al. Sequence requirements for plasmid nuclear import. Exp Cell Res 1999; 253:713–722. 29. Porgador A, Irvine KR, Iwasaki A, et al. Predominant role for directly transfected dendritic cells in antigen presentation to CD8þ T cells after gene gun immunization. J Exp Med 1998; 188:1075–1082. 30. Barry MA, Johnston SA. Biological features of genetic immunization. Vaccine 1997; 15:788–791. 31. Condon C, Watkins SC, Celluzzi CM, et al. DNA-based immunization by in vivo transfection of dendritic cells. Nat Med 1996; 2:1122–1128. 32. Haddad D, Ramprakash J, Sedegah M, et al. Plasmid vaccine expressing granulocyte-macrophage colony-stimulating factor attracts infiltrates including immature dendritic cells into injected muscles. J Immunol 2000; 65:3772–3781. 33. Bins AD, Jorritsma A, Wolkers MC, et al. A rapid and potent DNA vaccination strategy defined by in vivo monitoring of antigen expression. Nat Med 2005; 11: 899–904. 34. Manam SB, Ledwith J, Barnum AB, et al. Plasmid DNA vaccines: tissue distribution and effects of DNA sequence, adjuvants and delivery method on integration into host DNA. Intervirology 2000; 43:273–281. 35. Denis-Mize KS, Dupuis M, MacKichan ML, et al. Plasmid DNA adsorbed onto cationic microparticles mediates target gene expression and antigen presentation by dendritic cells. Gene Ther 2000; 7:2105–2112. 36. Dupuis M, Denis-Mize MK, Woo C, et al. Distribution of DNA vaccines determines their immunogenicity after intramuscular injection in mice. J Immunol 2000; 165:2850–2858. 37. Maloy KL, Erdmann I, Basch V, et al. Intralymphatic immunization enhances DNA vaccination. Proc Natl Acad Sci USA 2001; 98:3299–3303. 38. Carcaboso AM, Hernández RM, Igartua M, et al. Enhancing immunogenicity and reducing dose of microparticulated synthetic vaccines: single intradermal administration. Pharm Res 2004; 21:121–126. 39. Velders MP, Weijzen S, Eiben GL. Defined flanking spacers and enhanced proteolysis is essential for eradication of established tumors by an epitope string DNA vaccine. J Immunol 2001; 166:5366–5373.
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Translational Medicine Series 6 Can
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TRANSLATIONAL MEDICINE SERIES 1. Pr
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Informa Healthcare USA, Inc. 52 Van
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Preface Throughout the last 20 year
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Preface vii Table 1 A Diverse Techn
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Preface . . . . v Contributors . .
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Contributors Pedro Alves Ludwig Ins
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1 Factoring in Antigen Processing i
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Factoring in Antigen Processing in
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2 Outlining the Gap Between Preclin
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Preclinical Models and Clinical Sit
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Table 1 Examples of Preclinical Act
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56 Srinivasan disease agents. Garda
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58 Srinivasan expressing various kn
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60 Srinivasan The above-mentioned a
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62 Srinivasan (69). In another stud
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64 Srinivasan patients with prostat
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66 Srinivasan 33. Salgia R, Lynch T
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68 Srinivasan 67. Werness BA, Levin
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70 Teofilovici and Wentworth In 190
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74 Teofilovici and Wentworth Lipono
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78 Teofilovici and Wentworth nature
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80 Teofilovici and Wentworth In the
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82 Teofilovici and Wentworth 17. Ba
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84 Luptrawan et al. Dendritic cells
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86 Luptrawan et al. of cancer cells
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88 Luptrawan et al. NK cells can ki
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90 Luptrawan et al. Figure 2 Repres
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92 Luptrawan et al. state (50). Pat
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94 Luptrawan et al. ability of TIL
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96 Luptrawan et al. Figure 4 Drug s
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98 Luptrawan et al. Figure 6 Tumor
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Diagnostic Approaches to Maximize T
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206 Index Antigenic peptides degrad
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208 Index Chromogens, enzymatic act
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210 Index Freund’s adjuvants. See
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212 Index Langerhans cells, 133, 13
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214 Index [Peptide vaccines] invest
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216 Index TCRL. See TCR-like immuno
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Oncology and Immunology about the b
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