Download File - JOHN J. HADDAD, Ph.D.

More documents

Recommendations

Info

Development of Novel Immunotherapeutics 159 Figure 5 (See color insert.) A schematic representation of induction, expansion, differentiation, and migration of tumor antigen–specific T cells upon vaccination against tumor-associated antigens. Abbreviations: TcN, T cytotoxic naive; Tc NA, Tc naive activated; Tc CM, Tc central memory; Tc CE, Tc effectors; Tc PM, Tc peripheral memory; Tc PE, Tc peripheral effectors.
160 Bot and Obrocea 2. Inducting disease reduction or complete remission by chemotherapy prior to initiation of active immunotherapy, aimed to reduce the tumor burden and thus enable the overall activity of immunity; and 3. Interfering with checkpoints or immune breaks within tumor tissue, thus enabling the activity of effector T cells—for example, by interfering with T regulatory cells. This concept is being currently evaluated in clinic as such or in various formats: nonmyeloablative transient lymphodepletion by cyclophosphamide and/ or fludarabine followed by vaccination (1), myeloablative chemoradiotherapy followed by autologous T-lymphocyte transfer, and vaccination plus IL-2 (2) or combination approaches of vaccines plus biological response modifiers such as anti-CTLA-4 monoclonal antibodies (3). The differential activity of tumor antigen–specific T cells within lymphoid organs, peripheral organs bearing micrometastases versus larger tumors, can be readily analyzed in preclinical models with key impact on understanding the translation to clinic. For example, immunocompetent mice bearing large primary tumors and micrometastases mount immune responses upon vaccination against tumor-specific antigens to explore the impact of specific T cells on the viability of antigen-bearing target cells within large tumors, or systemically, an in vivo CFSE cytotoxic assay can be employed (Fig. 6). Control cells (“mock”) and antigen-expressing cells (“targets”) tagged with CFSE at a different intensity can Figure 6 Schematic representation of a prototype study to assess the systemic versus local functionality of tumor-specific T cells.
Page 1 and 2:
Translational Medicine Series 6 Can
Page 3 and 4:
TRANSLATIONAL MEDICINE SERIES 1. Pr
Page 5 and 6:
Informa Healthcare USA, Inc. 52 Van
Page 8 and 9:
Preface Throughout the last 20 year
Page 10 and 11:
Preface vii Table 1 A Diverse Techn
Page 12 and 13:
Preface . . . . v Contributors . .
Page 14 and 15:
Contributors Pedro Alves Ludwig Ins
Page 16 and 17:
1 Factoring in Antigen Processing i
Page 18 and 19:
Factoring in Antigen Processing in
Page 20 and 21:
Page 22 and 23:
Page 24 and 25:
Page 26 and 27:
Page 28 and 29:
Page 30 and 31:
Page 32 and 33:
Page 34 and 35:
Page 36 and 37:
Page 38 and 39:
Page 40 and 41:
Page 42 and 43:
Page 44 and 45:
Page 46 and 47:
2 Outlining the Gap Between Preclin
Page 48 and 49:
Preclinical Models and Clinical Sit
Page 50 and 51:
Table 1 Examples of Preclinical Act
Page 52 and 53:
Page 54 and 55:
Page 56 and 57:
Page 58 and 59:
Page 60 and 61:
Page 62 and 63:
Page 64 and 65:
Page 66 and 67:
Page 68:
Page 71 and 72:
56 Srinivasan disease agents. Garda
Page 73 and 74:
58 Srinivasan expressing various kn
Page 75 and 76:
60 Srinivasan The above-mentioned a
Page 77 and 78:
62 Srinivasan (69). In another stud
Page 79 and 80:
64 Srinivasan patients with prostat
Page 81 and 82:
66 Srinivasan 33. Salgia R, Lynch T
Page 83 and 84:
68 Srinivasan 67. Werness BA, Levin
Page 85 and 86:
70 Teofilovici and Wentworth In 190
Page 87 and 88:
72 Teofilovici and Wentworth conduc
Page 89 and 90:
74 Teofilovici and Wentworth Lipono
Page 91 and 92:
76 Teofilovici and Wentworth (best
Page 93 and 94:
78 Teofilovici and Wentworth nature
Page 95 and 96:
80 Teofilovici and Wentworth In the
Page 97 and 98:
82 Teofilovici and Wentworth 17. Ba
Page 99 and 100:
84 Luptrawan et al. Dendritic cells
Page 101 and 102:
86 Luptrawan et al. of cancer cells
Page 103 and 104:
88 Luptrawan et al. NK cells can ki
Page 105 and 106:
90 Luptrawan et al. Figure 2 Repres
Page 107 and 108:
92 Luptrawan et al. state (50). Pat
Page 109 and 110:
94 Luptrawan et al. ability of TIL
Page 111 and 112:
96 Luptrawan et al. Figure 4 Drug s
Page 113 and 114:
98 Luptrawan et al. Figure 6 Tumor
Page 115 and 116:
Table 1 Summary of results of phase
Page 117 and 118:
102 Luptrawan et al. Table 1 Summar
Page 119 and 120:
104 Luptrawan et al. antigens (84,8
Page 121 and 122:
106 Luptrawan et al. 30. Ranges GE,
Page 123 and 124:
108 Luptrawan et al. 66. Dunn GP, B
Page 125 and 126:
110 Schroter and Minev proteins (2,
Page 127 and 128: 112 Schroter and Minev tumor-challe
Page 129 and 130: 114 Schroter and Minev Table 1 Inve
Page 131 and 132: 116 Schroter and Minev Table 1 Inve
Page 133 and 134: 118 Schroter and Minev demonstrated
Page 135 and 136: 120 Schroter and Minev loaded MART-
Page 137 and 138: 122 Schroter and Minev illustrate t
Page 139 and 140: 124 Schroter and Minev 4. Heemels M
Page 141 and 142: 126 Schroter and Minev 42. Minev BR
Page 143 and 144: 128 Schroter and Minev 74. Restifo
Page 146 and 147: 7 Multimodality Immunization Approa
Page 148 and 149: Multimodality Immunization Approach
Page 162 and 163: Figure 5.1 Immunohistochemical char
Page 164 and 165: Figure 8.5 A schematic representati
Page 170 and 171: 8 Bidirectional Bedside Lab Bench P
Page 172 and 173: Development of Novel Immunotherapeu
Page 200 and 201: 9 Diagnostic Approaches for Selecti
Page 202 and 203: Diagnostic Approaches to Maximize T
Page 222: Diagnostic Approaches to Maximize T
Page 225 and 226: 206 Index Antigenic peptides degrad
Page 227 and 228: 208 Index Chromogens, enzymatic act
Page 229 and 230:
210 Index Freund’s adjuvants. See
Page 231 and 232:
212 Index Langerhans cells, 133, 13
Page 233 and 234:
214 Index [Peptide vaccines] invest
Page 235 and 236:
216 Index TCRL. See TCR-like immuno
Page 238:
Oncology and Immunology about the b
show all

Download File - JOHN J. HADDAD, Ph.D.

Create successful ePaper yourself

Delete template?

Save as template?