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Preface . . . . v Contributors . . . . xi Contents 1. Factoring in Antigen Processing in Designing Antitumor T-Cell Vaccines . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Frédéric Lévy, Sara Colombetti, Jozef Janda, Laurence Chapatte, Pedro Alves, Javier Garcia Casado, Nicole Lévy, and Anne-Lise Peitrequin 2. Outlining the Gap Between Preclinical Models and Clinical Situation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 31 Daniel L. Levey 3. Therapeutic and Prophylactic Cancer Vaccines: Emerging Perspectives from Allogeneic and Infectious Disease Vaccines . . . . . . . . . . . . . . . . . . . . . . . . . . . 55 Roopa Srinivasan 4. Personalized Cancer Vaccines . . . . . . . . . . . . . . . . . . . . . . . . . 69 Florentina Teofilovici and Kerry Wentworth 5. Dendritic Cell Vaccines for Gliomas . . . . . . . . . . . . . . . . . . . . 83 Anne Luptrawan, Gentao Liu, Suzane Brian, and John S. Yu 6. Peptide-Based Active Immunotherapy in Cancer . . . . . . . . . . 109 Stephanie Schroter and Boris Minev ix
x Contents 7. Multimodality Immunization Approaches to Improve on DNA Vaccines for Cancer . . . . . . . . . . . . . . . . . . . . . . . . . . 131 Zhiyong Qiu and Kent A. Smith 8. Bidirectional Bedside Lab Bench Processes and Flexible Trial Design as a Means to Expedite the Development of Novel Immunotherapeutics . . . . . . . . . . . . . . . . . . . . . . . . 151 Adrian Bot and Mihail Obrocea 9. Diagnostic Approaches for Selecting Patient-Customized Therapies, Obviating Tumor Variability to Maximize Therapeutic Effect . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 181 Chih-Sheng Chiang, Nathalie Kertesz, and Zheng Liu Index . . . . 205
Page 1 and 2: Translational Medicine Series 6 Can
Page 3 and 4: TRANSLATIONAL MEDICINE SERIES 1. Pr
Page 5 and 6: Informa Healthcare USA, Inc. 52 Van
Page 8 and 9: Preface Throughout the last 20 year
Page 10 and 11: Preface vii Table 1 A Diverse Techn
Page 14 and 15: Contributors Pedro Alves Ludwig Ins
Page 16 and 17: 1 Factoring in Antigen Processing i
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Page 46 and 47: 2 Outlining the Gap Between Preclin
Page 48 and 49: Preclinical Models and Clinical Sit
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Preclinical Models and Clinical Sit
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56 Srinivasan disease agents. Garda
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58 Srinivasan expressing various kn
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60 Srinivasan The above-mentioned a
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62 Srinivasan (69). In another stud
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64 Srinivasan patients with prostat
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66 Srinivasan 33. Salgia R, Lynch T
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68 Srinivasan 67. Werness BA, Levin
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70 Teofilovici and Wentworth In 190
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72 Teofilovici and Wentworth conduc
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74 Teofilovici and Wentworth Lipono
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76 Teofilovici and Wentworth (best
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78 Teofilovici and Wentworth nature
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80 Teofilovici and Wentworth In the
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82 Teofilovici and Wentworth 17. Ba
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84 Luptrawan et al. Dendritic cells
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86 Luptrawan et al. of cancer cells
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88 Luptrawan et al. NK cells can ki
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90 Luptrawan et al. Figure 2 Repres
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92 Luptrawan et al. state (50). Pat
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94 Luptrawan et al. ability of TIL
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96 Luptrawan et al. Figure 4 Drug s
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98 Luptrawan et al. Figure 6 Tumor
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Table 1 Summary of results of phase
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102 Luptrawan et al. Table 1 Summar
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104 Luptrawan et al. antigens (84,8
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106 Luptrawan et al. 30. Ranges GE,
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108 Luptrawan et al. 66. Dunn GP, B
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110 Schroter and Minev proteins (2,
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112 Schroter and Minev tumor-challe
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114 Schroter and Minev Table 1 Inve
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116 Schroter and Minev Table 1 Inve
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118 Schroter and Minev demonstrated
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120 Schroter and Minev loaded MART-
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122 Schroter and Minev illustrate t
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124 Schroter and Minev 4. Heemels M
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126 Schroter and Minev 42. Minev BR
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128 Schroter and Minev 74. Restifo
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7 Multimodality Immunization Approa
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Multimodality Immunization Approach
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Figure 5.1 Immunohistochemical char
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Figure 8.5 A schematic representati
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8 Bidirectional Bedside Lab Bench P
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Development of Novel Immunotherapeu
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9 Diagnostic Approaches for Selecti
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Diagnostic Approaches to Maximize T
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206 Index Antigenic peptides degrad
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208 Index Chromogens, enzymatic act
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210 Index Freund’s adjuvants. See
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212 Index Langerhans cells, 133, 13
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214 Index [Peptide vaccines] invest
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216 Index TCRL. See TCR-like immuno
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Oncology and Immunology about the b
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