Download File - JOHN J. HADDAD, Ph.D.
Download File - JOHN J. HADDAD, Ph.D.
Download File - JOHN J. HADDAD, Ph.D.
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Table 1 Examples of Preclinical Activity in Rodents Treated with Autologous Cancer Vaccines: Effect of Tumor Burden on Outcome<br />
(Continued )<br />
Cancer type Vaccine type Efficacy Disease settings<br />
Preclinical Models and Clinical Situation 35<br />
Early: treatment started 1 day after tumor<br />
challenge<br />
Moderately advanced: treatment started 7 days<br />
after tumor challenge<br />
Advanced: treatment started 14 days after tumor<br />
100% complete tumor rejection (cure) in early<br />
setting vs. 60% cure in moderately advanced<br />
disease setting and 30% cure in advanced<br />
disease setting (14)<br />
Breast IL-2–transduced tumor<br />
cells<br />
challenge<br />
Early: treatment started 6 days after tumor<br />
challenge<br />
Advanced: treatment started 9 days after tumor<br />
challenge<br />
Minimal disease: primary tumor surgically<br />
removed prior to start of vaccination, yet still<br />
bore second tumor at distal site<br />
Bulky disease: no surgical resection and thus<br />
bore primary and secondary tumor at time of<br />
vaccination<br />
Early: treatment started 3 days after tumor<br />
challenge<br />
Moderately advanced: treatment started 7–10<br />
days after tumor challenge<br />
Early: treatment started 3 days after tumor<br />
challenge<br />
Moderately advanced: treatment started 10 days<br />
after tumor challenge<br />
Advanced: treatment started 17 days after tumor<br />
challenge<br />
70% of mice alive at day 200 (end of study) in<br />
early setting compared with 0% in control<br />
group vs. 20% alive in advanced disease (15)<br />
Kidney IL-4–transduced tumor<br />
cells<br />
Significant reduction in rate of tumor growth in<br />
minimal disease setting vs. no effect of<br />
vaccination in bulky disease setting (16)<br />
Mesothelioma B7-1–transduced tumor<br />
cells<br />
87% complete tumor rejection (cure) in early<br />
setting vs. 0% cure in moderately advanced<br />
disease setting (17)<br />
Myeloma TNF-a–transduced and<br />
B7-1–transduced tumor<br />
cells<br />
83% of mice alive at day 71 (end of study) in<br />
early setting, 34% alive in moderately<br />
advanced disease setting, and 0% alive in<br />
advanced disease setting (18)<br />
Fibrosarcoma IFN-g–transduced and<br />
B7-1–transduced tumor<br />
cells<br />
(Continued)