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Factoring in Antigen Processing in Designing Antitumor T-Cell Vaccines 23 33. Wherry EJ, Golovina TN, Morrison SE, et al. Re-evaluating the generation of a “proteasome-independent” MHC class I-restricted CD8 T cell epitope. J Immunol 2006; 176:2249–2261. 34. Towne CF, York IA, Watkin LB, et al. Analysis of the role of bleomycin hydrolase in antigen presentation and the generation of CD8 T cell responses. J Immunol 2007; 178:6923–6930. 35. Lévy F, Burri L, Morel S, et al. The final N-terminal trimming of a subaminoterminal proline-containing HLA class I-restricted antigenic peptide in the cytosol is mediated by two peptidases. J Immunol 2002; 169:4161–4171. 36. Reits E, Neijssen J, Herberts C, et al. A major role for TPPII in trimming proteasomal degradation products for MHC class I antigen presentation. Immunity 2004; 20:495–506. 37. York IA, Bhutani N, Zendzian S, et al. Tripeptidyl peptidase II is the major peptidase needed to trim long antigenic precursors, but is not required for most MHC class I antigen presentation. J Immunol 2006; 177:1434–1443. 38. Basler M and Groettrup M. No essential role for tripeptidyl peptidase II for the processing of LCMV-derived T cell epitopes. Eur J Immunol 2007; 37: 896–904. 39. York IA, Mo AXY, Lemerise K, et al. The cytosolic endopeptidase, thimet oligopeptidase, destroys antigenic peptides and limits the extent of MHC class I antigen presentation. Immunity 2003; 18:429–440. 40. Geier E, Pfeifer G, Wilm M, et al. A giant protease with potential to substitute for some functions of the proteasome. Science 1999; 283:978–981. 41. Seifert U, Maranon C, Shmueli A, et al. An essential role for tripeptidyl peptidase in the generation of an MHC class I epitope. Nat Immunol 2003; 4:375–379. 42. Serwold T, Gonzalez F, Kim J, et al. ERAAP customizes peptides for MHC class I molecules in the endoplasmic reticulum. Nature 2002; 419:480–483. 43. Saric T, Chang S-C, Hattori A, et al. An IFN-b–induced aminopeptidase in the ER, ERAP1, trims precursors to MHC class I–presented peptides. Nat Immunol 2002; 3:1169–1176. 44. Saveanu L, Carroll O, Lindo V, et al. Concerted peptide trimming by human ERAP1 and ERAP2 aminopeptidase complexes in the endoplasmic reticulum. Nat Immunol 2005; 6:689–697. 45. Serwold T, Gaw S, Shastri N. ER aminopeptidases generate a unique pool of peptides for MHC class I molecules. Nat Immunol 2001; 2:644–651. 46. Uebel S, Kraas W, Kienle S, et al. Recognition principle of the TAP transporter disclosed by combinatorial peptide libraries. Proc Natl Acad Sci USA 1997; 94:8976–8981. 47. York IA, Brehm MA, Zendzian S, et al. Endoplasmic reticulum aminopeptidase 1 (ERAP1) trims MHC class I-presented peptides in vivo and plays an important role in immunodominance. Proc Natl Acad Sci USA 2006; 103:9202–9207. 48. Firat E, Saveanu L, Aichele P, et al. The role of endoplasmic reticulum-associated aminopeptidase 1 in immunity to infection and in cross-presentation. J Immunol 2007; 178:2241–2248. 49. York IA, Chang S-C, Saric T, et al. The ER aminopeptidase ERAP1 enhances or limits antigen presentation by trimming epitopes to 8–9 residues. Nat Immunol 2002; 3:1177–1184.
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Page 1 and 2: Translational Medicine Series 6 Can
Page 3 and 4: TRANSLATIONAL MEDICINE SERIES 1. Pr
Page 5 and 6: Informa Healthcare USA, Inc. 52 Van
Page 8 and 9: Preface Throughout the last 20 year
Page 10 and 11: Preface vii Table 1 A Diverse Techn
Page 12 and 13: Preface . . . . v Contributors . .
Page 14 and 15: Contributors Pedro Alves Ludwig Ins
Page 16 and 17: 1 Factoring in Antigen Processing i
Page 18 and 19: Factoring in Antigen Processing in
Page 46 and 47: 2 Outlining the Gap Between Preclin
Page 48 and 49: Preclinical Models and Clinical Sit
Page 50 and 51: Table 1 Examples of Preclinical Act
Page 68: Preclinical Models and Clinical Sit
Page 71 and 72: 56 Srinivasan disease agents. Garda
Page 73 and 74: 58 Srinivasan expressing various kn
Page 75 and 76: 60 Srinivasan The above-mentioned a
Page 77 and 78: 62 Srinivasan (69). In another stud
Page 79 and 80: 64 Srinivasan patients with prostat
Page 81 and 82: 66 Srinivasan 33. Salgia R, Lynch T
Page 83 and 84: 68 Srinivasan 67. Werness BA, Levin
Page 85 and 86: 70 Teofilovici and Wentworth In 190
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74 Teofilovici and Wentworth Lipono
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76 Teofilovici and Wentworth (best
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78 Teofilovici and Wentworth nature
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80 Teofilovici and Wentworth In the
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82 Teofilovici and Wentworth 17. Ba
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84 Luptrawan et al. Dendritic cells
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86 Luptrawan et al. of cancer cells
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88 Luptrawan et al. NK cells can ki
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90 Luptrawan et al. Figure 2 Repres
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92 Luptrawan et al. state (50). Pat
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94 Luptrawan et al. ability of TIL
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96 Luptrawan et al. Figure 4 Drug s
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98 Luptrawan et al. Figure 6 Tumor
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Table 1 Summary of results of phase
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102 Luptrawan et al. Table 1 Summar
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104 Luptrawan et al. antigens (84,8
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106 Luptrawan et al. 30. Ranges GE,
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108 Luptrawan et al. 66. Dunn GP, B
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110 Schroter and Minev proteins (2,
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112 Schroter and Minev tumor-challe
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114 Schroter and Minev Table 1 Inve
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116 Schroter and Minev Table 1 Inve
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118 Schroter and Minev demonstrated
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120 Schroter and Minev loaded MART-
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122 Schroter and Minev illustrate t
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124 Schroter and Minev 4. Heemels M
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126 Schroter and Minev 42. Minev BR
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128 Schroter and Minev 74. Restifo
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7 Multimodality Immunization Approa
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Multimodality Immunization Approach
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Figure 5.1 Immunohistochemical char
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Figure 8.5 A schematic representati
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8 Bidirectional Bedside Lab Bench P
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Development of Novel Immunotherapeu
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9 Diagnostic Approaches for Selecti
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Diagnostic Approaches to Maximize T
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206 Index Antigenic peptides degrad
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208 Index Chromogens, enzymatic act
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210 Index Freund’s adjuvants. See
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212 Index Langerhans cells, 133, 13
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214 Index [Peptide vaccines] invest
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216 Index TCRL. See TCR-like immuno
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Oncology and Immunology about the b
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