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Table 1 Examples of Preclinical Activity in Rodents Treated with Autologous Cancer Vaccines: Effect of Tumor Burden on Outcome (Continued ) Cancer type Vaccine type Efficacy Disease settings Preclinical Models and Clinical Situation 35 Early: treatment started 1 day after tumor challenge Moderately advanced: treatment started 7 days after tumor challenge Advanced: treatment started 14 days after tumor 100% complete tumor rejection (cure) in early setting vs. 60% cure in moderately advanced disease setting and 30% cure in advanced disease setting (14) Breast IL-2–transduced tumor cells challenge Early: treatment started 6 days after tumor challenge Advanced: treatment started 9 days after tumor challenge Minimal disease: primary tumor surgically removed prior to start of vaccination, yet still bore second tumor at distal site Bulky disease: no surgical resection and thus bore primary and secondary tumor at time of vaccination Early: treatment started 3 days after tumor challenge Moderately advanced: treatment started 7–10 days after tumor challenge Early: treatment started 3 days after tumor challenge Moderately advanced: treatment started 10 days after tumor challenge Advanced: treatment started 17 days after tumor challenge 70% of mice alive at day 200 (end of study) in early setting compared with 0% in control group vs. 20% alive in advanced disease (15) Kidney IL-4–transduced tumor cells Significant reduction in rate of tumor growth in minimal disease setting vs. no effect of vaccination in bulky disease setting (16) Mesothelioma B7-1–transduced tumor cells 87% complete tumor rejection (cure) in early setting vs. 0% cure in moderately advanced disease setting (17) Myeloma TNF-a–transduced and B7-1–transduced tumor cells 83% of mice alive at day 71 (end of study) in early setting, 34% alive in moderately advanced disease setting, and 0% alive in advanced disease setting (18) Fibrosarcoma IFN-g–transduced and B7-1–transduced tumor cells (Continued)
36 Levey Table 1 Examples of Preclinical Activity in Rodents Treated with Autologous Cancer Vaccines: Effect of Tumor Burden on Outcome (Continued ) Cancer type Vaccine type Efficacy Disease settings Early: treatment started 10 days after tumor challenge Advanced: treatment started 20 days after tumor 33% of mice alive at end of study (>180 days) in early setting compared with 0% in control group vs. 13% alive in advanced disease (19) Liver Tumor cells mixed with BCG challenge Early: treatment started 1 day after tumor challenge Advanced: treatment started 4 days after tumor challenge Early: treatment started same day as tumor challenge Advanced: treatment started 3 days after tumor challenge 40% of mice alive at end of study (>180 days) in early setting compared with 0% in control group vs. 0% alive in advanced disease (20) Liver Tumor cells mixed with BCG 23% of mice alive at end of study (>60 days) in early setting compared with 0% in control group vs. 0% alive in advanced disease (21) Lymphoma Adenovirus-encoding idiotype þ cyclophosphamide Abbreviations: HSPPC-96, heat shock protein–peptide complex; GM-CSF, granulocyte macrophage colony–stimulating factor; IL-12, interleukin 12; IL-2, interleukin 2; IL-4, interleukin 4; TNF-a, tumor necrosis factor a; IFN-g, interferon g; BCG, bacille Calmette–Guérin.
Page 1 and 2: Translational Medicine Series 6 Can
Page 3 and 4: TRANSLATIONAL MEDICINE SERIES 1. Pr
Page 5 and 6: Informa Healthcare USA, Inc. 52 Van
Page 8 and 9: Preface Throughout the last 20 year
Page 10 and 11: Preface vii Table 1 A Diverse Techn
Page 12 and 13: Preface . . . . v Contributors . .
Page 14 and 15: Contributors Pedro Alves Ludwig Ins
Page 16 and 17: 1 Factoring in Antigen Processing i
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7 Multimodality Immunization Approa
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Multimodality Immunization Approach
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Figure 5.1 Immunohistochemical char
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Figure 8.5 A schematic representati
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8 Bidirectional Bedside Lab Bench P
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Development of Novel Immunotherapeu
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Diagnostic Approaches to Maximize T
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206 Index Antigenic peptides degrad
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208 Index Chromogens, enzymatic act
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210 Index Freund’s adjuvants. See
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212 Index Langerhans cells, 133, 13
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214 Index [Peptide vaccines] invest
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216 Index TCRL. See TCR-like immuno
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Oncology and Immunology about the b
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