Self-Assembly of Synthetic and Biological Polymeric Systems of ...

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2.3 2.4 2.5 2.6 2.7 2.8 2.9 2.10 2.11 2.12 2.3.1 2.3.2 2.4.1 2.4.2 2.9.1 2.11.1 2.11.2 2.11.3 2.11.4 2.11.5 Chapter 3 Light scattering Static light scattering (SLS) Dynamic light scattering (DLS) Electron microscopy Transmission electron microscopy (TEM) Scanning electron microscopy (SEM) Atomic force microscopy (AFM) Fluorescence spectroscopy Circular dichroism (CD) Infrared spectroscopy Rheology Viscoelasticity X-ray diffraction Additional experimental techniques used in fibrillogenesis studies Block copolymers 3.1 3.2 3.3 UV-Vis spectroscopy Polarized light optical microscopy Emission spectroscopy Superconducting quantum interference device (SQUID) Magnetic resonance imaging (MRI) Laboratory equipment Introduction Behaviour of block copolymers in solution Mechanisms of morphologic control and thermodynamic stability 32 36 40 44 44 46 47 48 52 54 58 59 64 72 72 75 77 78 80 82 91 93 95 viii
3.4 3.5 Chapter 4 Papers on block copolymers 4.1 4.2 4.3 4.3.1 Chapter 5 Proteins 5.1 5.2 5.3 5.1.1 5.1.2 5.1.3 5.1.4 5.2.1 5.2.2 5.2.3 5.2.4 5.3.1 Block copolymers of polyoxyalkylenes in aqueous solution E12S10, E10S10E10 and E137S18E137 block copolymers Self-Assembly process of different poly(oxystyrene)- poly(oxyethylene) block copolymers: spontaneous formation of vesicular structures and elongated micelles. Surface properties of monolayers of amphiphilic poly(ethylene oxide)-poly(styrene oxide) block copolymers. Appended papers Relevant aspects Protein structure Primary structure of the proteins Secondary structure of the proteins Tertiary structure of the proteins Quaternary structure of the proteins Protein aggregation Unfolded state Intermediate and transition state assembles Native state Energy landscape: protein aggregation Amyloid fibrils Amyloid fibrils hallmarks 96 97 103 113 123 124 127 128 129 131 132 132 133 133 134 135 135 135 ix
Page 1: Grupo de Física de Coloides y Pol
Page 5: Agradecimientos A mi Familia A mi P
Page 9: v List of papers I. Self-assembly p
Page 14 and 15: 5.4 5.5 5.3.2 5.5.1 Chapter 6 Kinet
Page 16 and 17: amiloides de la proteína albúmina
Page 18 and 19: vesiculares son el resultado de la
Page 20 and 21: origina debido a condiciones ambien
Page 22 and 23: con las fibras vecinas más cercana
Page 25 and 26: Abstract In the present work, we in
Page 27: [Au]/[protein] molar ratio and numb
Page 30 and 31: synthetic polymers are obtained fro
Page 32 and 33: On the other hand, in terms of chem
Page 34 and 35: Additionally, to obtain a better kn
Page 36 and 37: therefore, characteristic of solid
Page 38 and 39: presence of electrostatic charge in
Page 41 and 42: Contents 2.1 2.2 2.3 2.4 2.5 2.6 2.
Page 43 and 44: where w is the meniscus’ weight d
Page 45 and 46: that they exert little force one on
Page 47 and 48: This oscillating dipole acts as an
Page 49 and 50: (APD) and its associated optics (pi
Page 51 and 52: where r is the distance of the dipo
Page 53 and 54: When , the former equation can be s
Page 55 and 56: autocorrelation function (ACF). In
Page 57 and 58: and, therefore, . The autocorrelati
Page 59 and 60: A transmission electron microscope
Page 61 and 62: 2.5.- Atomic force microscopy (AFM)
Page 63 and 64:
ecause of the energy loss in the ex
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Figure 2.15. Schematic representati
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ackbone of proteins. Since proteins
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According to classical mechanics, t
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chemical composition, configuration
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2.9.1.- Viscoelasticity Many materi
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where is the total strain rate, whi
Page 77 and 78:
Using equations 2.40 and 2.41 in eq
Page 79 and 80:
scattering process that incoming X-
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maximum intensity of the peak, Imax
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translation of the reciprocal latti
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For a single crystal, the chance to
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excitation; namely, a valance elect
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Figure 2.27. Distinction between si
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microscope, there are two polarized
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In particular, we use SQUID to meas
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are aligned by means of an external
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on the digital profile of a drop im
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Laser confocal microscopy. Confocal
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Fluorescence spectroscopy. Fluoresc
Page 103:
Superconducting quantum interferenc
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temperatures, the chains are mixed
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e detected by a given method. Therm
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subsequently, of their thermodynami
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a) O b) H 2C CH 2 O H 2C CH Figure
Page 115:
Contents 4.1 4.2 4.3 4.3.1 CHAPTER
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7108 Langmuir, Vol. 24, No. 14, 200
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7110 Langmuir, Vol. 24, No. 14, 200
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7112 Langmuir, Vol. 24, No. 14, 200
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7114 Langmuir, Vol. 24, No. 14, 200
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7116 Langmuir, Vol. 24, No. 14, 200
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15704 J. Phys. Chem. C, Vol. 114, N
Page 130 and 131:
Page 132 and 133:
Page 134 and 135:
Page 136 and 137:
Page 138 and 139:
4.3.1.- Relevant aspects I. For E12
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Contents 5.1 5.2 5.3 5.4 5.5 5.1.1
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acids whose lateral side chains cha
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adjacent segments of an antiparalle
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5.2.1.- Unfolded state Over the las
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5.2.4.- Energy landscape: protein a
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molecular medicine viewpoint, prote
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shows the typical nucleation-depend
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the energy landscape of the aggrega
Page 157:
exposed loop region. The secondary
Page 161 and 162:
Biophysical Journal Volume 96 March
Page 163 and 164:
Fibrillation Pathway of HSA 2355 q
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Fibrillation Pathway of HSA 2357 mo
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Fibrillation Pathway of HSA 2359 in
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Fibrillation Pathway of HSA 2361 Fu
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Fibrillation Pathway of HSA 2363 FI
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Fibrillation Pathway of HSA 2365 Wh
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Fibrillation Pathway of HSA 2367 of
Page 177 and 178:
Fibrillation Pathway of HSA 2369 17
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Influence of Electrostatic Interact
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Fibrillation Process of Human Serum
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Page 185 and 186:
Page 187:
Page 190 and 191:
12392 J. Phys. Chem. B, Vol. 113, N
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Page 194 and 195:
Page 196 and 197:
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5 10 15 20 25 30 35 40 45 Soft Matt
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5 10 15 20 25 r h,app = kT/(6πηD
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5 10 15 20 25 30 35 40 45 50 below,
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5 10 15 20 25 30 55 Figure 3: Selec
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10 15 Soft Matter Cite this: DOI: 1
Page 209 and 210:
5 10 15 Soft Matter Cite this: DOI:
Page 211:
5 65. L. A. Sikkink, M. Ramirez-Alv
Page 214 and 215:
ions would interact electrostatical
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pubs.acs.org/JPCL Figure 3. (a) Tim
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(54) Almeida, N. L.; Oliveira, C. L
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netospirillum magneticum strain AMB
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One-Dimensional Magnetic Nanowires
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temperatures, and solvent polarity.
Page 233 and 234:
Conclusions The work has two parts:
Page 235 and 236:
equire a highly organized and unsta
Page 237 and 238:
References 1. Hiemenz, Paul C. Poly
Page 239 and 240:
33. Wang, Z. L. HANDBOOK OF MICROSC
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67. Polymers Get Organized. Bucknal
Page 243 and 244:
94. Are there Pathways for Protein
Page 245 and 246:
123. Designing conditions for in vi
Page 247:
151. SERS-based diagnosis and biode
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