Self-Assembly of Synthetic and Biological Polymeric Systems of ...

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Nelson, Alshakim ; Meijer, E. W.; Yang, Yi Y. 2009, Angew. Chem. Int. Ed., Vol. 48, pp. 4508- 4512. 81. Influence of Ionic Surfactants on the Aggregation of Poly(Ethylene Oxide)-Poly(Propylene Oxide)-Poly(Ethylene Oxide) Block Copolymers Studied by Differential Scanning and Isothermal Titration Calorimetry . da Silva, R. C.; Olofsson, G.; Schillén, K.; Loh, W. 2002, J. Phys. Chem. B, Vol. 106, pp. 1239-1246. 82. Association and Surface Properties of Poly(ethylene oxide)−Poly(styrene oxide) Diblock Copolymers in Aqueous Solution. Mai, S. M.; Booth, C.; Kelaraskis, A.; Haverdraki, V.; Ryan, A. J. 2000, Langmuir, Vol. 16, pp. 1681-1688. 83. Association Properties of a Diblock Copolymer of Ethylene Oxide and Styrene Oxide in Aqueous Solution Studied by Light Scattering and Rheometry. Kelaraski, A.; Havedraki, V.; Rekatas, C. J.; Mai, S. M.; Attwood, D.; Booth, C.; Ryan, A. J.; Hamley, I. W.; Martini, I. 2001, Macromol. Chem Phys., Vol. 202, pp. 1345-1354. 84. Micellization and Gelation of Triblock Copolymers of Ethylene Oxide and Styrene Oxide in Aqueous Solution. Yang, Z.; Crothers, M.; Ricardo, N. M. P. S.; Chaibundit, C.; Taboada, P.; Mosquera, V.; Kelarakis, A.; Havredaki, V.; Mart, L.; Collect, H. J.; Attwood, D.; Heatley, F.; Booth, C. 2003, Langmuir, Vol. 19, pp. 943-950. 85. Katime, I. Química Física Macromolecular. Universidad del País Vasco : Servicio Editorial del País Vasco Euskal Herriko , 1994. 86. Bilayers and Interdigitation in Block Copolymer Vesicles. Battaglia, G.; Ryan, A. J. 2005, J. Am. Chem. Soc., Vol. 127, pp. 8757-8764. 87. Shear-Induced Formation of Multilamellar Vesicles (“Onions”) in Block Copolymers. Zipfel, J.; Lindner, M.; Tsinou, M.; Alexandridis, P.; Richtering, W. 1999, Langmuir, Vol. 15, pp. 2599- 2602. 88. The evolution of vesicles from bulk lamellar gels. Battaglia, G.; Ryan, A. J. 2005, Nature Materials, Vol. 4, pp. 869-876. 89. Spontaneous Vesicle Formation in a Block Copolymer System. Bryskhe, K.; Jansson, J.; Topgaard, D.; Schillén, K.; Olsson, U. J. 2004, J. Phys. Chem. B, Vol. 108, pp. 9710-9719. 90. Association behavior of mixed triblock copoly(oxyalkylene)s (type EBE and ESE) in aqueous solution. Ricardo, N. M. P. S.; Chaibundit, C.; Yang, Z.; Attwood, D.; Booth, C. 2006, Langmuir, Vol. 22, pp. 1301-1306. 91. Mixtures of triblock copolymers E62P39E62 and E137S18E137 potential for drug delivery from in situ gelling micellar formulations. Pinho, M. E. N.; Costa, F. M. L. L.; Filho, F. B. S.; Ricardo, N. M. P. S.; Yeates, S. G.; Attwood, D.; Booth, C. 2007, Int. J. Pharm., Vol. 328, pp. 95- 98. 92. Creighton, T. E. Proteins: structure and molecular. New York: Freeman, 1993. 93. Nelson, D. L.; Cox, M. M. Principles of biochemistry. New York: Freeman, 2008. 228
94. Are there Pathways for Protein Folding? Levinthal, C. 1968, J. Chim. Phys. Phys. Chim. Biol., Vol. 65, pp. 44-45. 95. Protein Folding and Unfolding at Atomic Resolution. Fersht, A. R.; Daggett, V. 2002, Cell , Vol. 108, pp. 573-582. 96. Understanding protein folding via free-energy surfaces from theory and experiment. Dinner, A. R.; Sali, A.; Smith, L. J.; Dobson, C. M.; Karplus, M. 2000, Trends Biochem. Sci. 25 (2000) 331–339., Vol. 25, pp. 331-339. 97. Navigating the Folding Routes. Wolynes, P. G.; Onuchic, J. N; Thirumalai, D. 1995, Science, Vol. 267, pp. 1619-1620. 98. Folding versus aggregation: Polypeptide conformations on competing pathways. Jahn, T. R.; Radford, S. E. 2008, Archives of Biochemistry and Biophysics, Vol. 469, pp. 100-117. 99. Towards complete descriptions of the free–energy landscapes of proteins. Vendruscolo, M.; Dobson, C. M. 2005, Philos. Transact. A Math. Phys. Eng. Sci., Vol. 363, pp. 433-450. 100. Protein Aggregation and Amyloid Fibril Formation by an SH3 Domain Probed by Limited Proteolysis. Polverino de Laureto, P.; Taddei, N.; Frare, E.; Capanni, C.; Costantini, S.; Zurdo,J.; Chiti, F.; Dobson, C. M.; Fontana, A. 2003, J. Mol. Biol., Vol. 334, pp. 129-141. 101. Folding funnels, binding funnels, and protein function. Tsai, C. J.; Kumar, S.; Nussinov, R. 1999, Protein Sci., Vol. 8, pp. 1181-1190. 102. Kinetics and thermodynamics of amyloid fibril assembly. Wetzel, R. 2006, Acc. Chem. Res., Vol. 39, pp. 671-679. 103. The protofilament structure of insulin amyloid fibrils. Jimenez, J. L.; Nettleton, E. J.; Bouchard, M.; Robinson, C. V.; Dobson, C. M.; Saibil, H. L. 14, 2002, PNAS, Vol. 99. 104. Hierarchical assembly of β2-microglobulin amyloid in vitro revealed by atomic force microscopy. Kad, N. M.; Myers, S. L.; Smith, D. P.; Smith, D. A.; Radford, S. E.; Thomson, N. H. 2003, J. Mol. Biol., Vol. 330, pp. 785–797. 105. Einige Bemerkungen über den vegetabilischen Faserstoff und sein Verhältniss zum Stärkemehl. Schleiden, M. J. 1838, Ann. Physik., Vol. 119, pp. 391-397. 106. On the structural definition of amyloid fibrils and other polypeptide aggregates. Fändrich, M. 2007, Cell. Mol. Life Sci., Vol. 64, pp. 2066-2078. 107. Amyloids: Not only pathological agents but also ordered nanomaterials. Cherny, I.; Gazit, E. 2008, Angew. Chem. Int., Vol. 47, pp. 4062-4069. 108. Prediction of the aggregation propensity of proteins from the primary sequence: Aggregation properties of proteomes. Castillo, V.; Graña-Montes, R.; Sabate, R.; Ventura, S. 2011, Biotechnol. J., Vol. 6, pp. 674-685. 229
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Grupo de Física de Coloides y Pol
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Agradecimientos A mi Familia A mi P
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v List of papers I. Self-assembly p
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2.3 2.4 2.5 2.6 2.7 2.8 2.9 2.10 2.
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5.4 5.5 5.3.2 5.5.1 Chapter 6 Kinet
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amiloides de la proteína albúmina
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vesiculares son el resultado de la
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origina debido a condiciones ambien
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con las fibras vecinas más cercana
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Abstract In the present work, we in
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[Au]/[protein] molar ratio and numb
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synthetic polymers are obtained fro
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On the other hand, in terms of chem
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Additionally, to obtain a better kn
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therefore, characteristic of solid
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presence of electrostatic charge in
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Contents 2.1 2.2 2.3 2.4 2.5 2.6 2.
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where w is the meniscus’ weight d
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that they exert little force one on
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This oscillating dipole acts as an
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(APD) and its associated optics (pi
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where r is the distance of the dipo
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When , the former equation can be s
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autocorrelation function (ACF). In
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and, therefore, . The autocorrelati
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A transmission electron microscope
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2.5.- Atomic force microscopy (AFM)
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ecause of the energy loss in the ex
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Figure 2.15. Schematic representati
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ackbone of proteins. Since proteins
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According to classical mechanics, t
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chemical composition, configuration
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2.9.1.- Viscoelasticity Many materi
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where is the total strain rate, whi
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Using equations 2.40 and 2.41 in eq
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scattering process that incoming X-
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maximum intensity of the peak, Imax
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translation of the reciprocal latti
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For a single crystal, the chance to
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excitation; namely, a valance elect
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Figure 2.27. Distinction between si
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microscope, there are two polarized
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In particular, we use SQUID to meas
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are aligned by means of an external
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on the digital profile of a drop im
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Laser confocal microscopy. Confocal
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Fluorescence spectroscopy. Fluoresc
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Superconducting quantum interferenc
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temperatures, the chains are mixed
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e detected by a given method. Therm
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subsequently, of their thermodynami
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a) O b) H 2C CH 2 O H 2C CH Figure
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Contents 4.1 4.2 4.3 4.3.1 CHAPTER
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7108 Langmuir, Vol. 24, No. 14, 200
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7110 Langmuir, Vol. 24, No. 14, 200
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7112 Langmuir, Vol. 24, No. 14, 200
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7114 Langmuir, Vol. 24, No. 14, 200
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7116 Langmuir, Vol. 24, No. 14, 200
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15704 J. Phys. Chem. C, Vol. 114, N
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4.3.1.- Relevant aspects I. For E12
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Contents 5.1 5.2 5.3 5.4 5.5 5.1.1
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acids whose lateral side chains cha
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adjacent segments of an antiparalle
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5.2.1.- Unfolded state Over the las
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5.2.4.- Energy landscape: protein a
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molecular medicine viewpoint, prote
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shows the typical nucleation-depend
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the energy landscape of the aggrega
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exposed loop region. The secondary
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Biophysical Journal Volume 96 March
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Fibrillation Pathway of HSA 2355 q
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Fibrillation Pathway of HSA 2357 mo
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Fibrillation Pathway of HSA 2359 in
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Fibrillation Pathway of HSA 2361 Fu
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Fibrillation Pathway of HSA 2363 FI
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Fibrillation Pathway of HSA 2365 Wh
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Fibrillation Pathway of HSA 2367 of
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Fibrillation Pathway of HSA 2369 17
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Influence of Electrostatic Interact
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Fibrillation Process of Human Serum
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12392 J. Phys. Chem. B, Vol. 113, N
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Page 199 and 200: 5 10 15 20 25 30 35 40 45 Soft Matt
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Page 211: 5 65. L. A. Sikkink, M. Ramirez-Alv
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Page 216: pubs.acs.org/JPCL Figure 3. (a) Tim
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Page 222 and 223: netospirillum magneticum strain AMB
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Page 230 and 231: temperatures, and solvent polarity.
Page 233 and 234: Conclusions The work has two parts:
Page 235 and 236: equire a highly organized and unsta
Page 237 and 238: References 1. Hiemenz, Paul C. Poly
Page 239 and 240: 33. Wang, Z. L. HANDBOOK OF MICROSC
Page 241: 67. Polymers Get Organized. Bucknal
Page 245 and 246: 123. Designing conditions for in vi
Page 247: 151. SERS-based diagnosis and biode
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