Barbieri Thesis - BioMedical Materials program (BMM)
Barbieri Thesis - BioMedical Materials program (BMM)
Barbieri Thesis - BioMedical Materials program (BMM)
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Chap pter 1 – Introducction<br />
thus to ccontrol<br />
tissue regeneration. Other strateg<br />
chemical<br />
compositioon<br />
in combin nation with its<br />
surface cchemistry<br />
and<br />
roughness were imitate<br />
precipitate<br />
from ultra– –saturated solutions<br />
(e.g. c<br />
onto the surface of ppolymer–,<br />
pep ptides sheets–<br />
Further mmethods<br />
to coontrol<br />
cells inc clude mimickin<br />
structure of natural (ssoft)<br />
tissue matrices m using<br />
designingg<br />
scaffolds witth<br />
various prop perties. Hydro<br />
swell in the<br />
presence of aqueous fluids<br />
maintain<br />
structure by virtue off<br />
chemical crosslinks.<br />
biocompaatibility<br />
and caan<br />
homogene<br />
bioactive compounds wwhile<br />
allowing<br />
[201]<br />
gies involve mimicking m the e surface<br />
s topography y. For examp ple, bone<br />
ed by letting g calcium phosphates<br />
concentrated simulated bod dy fluids)<br />
– or graphen ne–based bulk ks. [199, 200]<br />
ng the hydrated<br />
three–dim mensional<br />
g hydrogels, whose w tailorin ng allows<br />
ogels are polymeric<br />
materia als able to<br />
ing their three e–dimensional<br />
network<br />
In general, hydrogels ha ave good<br />
eously incorpoorate<br />
cells, gro owth factors and a other<br />
rapid diffusionn<br />
of nutrients and metabolites.<br />
Figure 5. ( (a) The Egyptian mummy of pries st Usermontu. (bb)<br />
Radiography of o Usermontu’s le eg showing<br />
the iron sticck<br />
inserted in the attempt of recov ver the walking fuunction<br />
of the leg g. (c) An example e of modern<br />
biomechaniical<br />
mimicry in caase<br />
of aortic sten nosis: man–madee<br />
heart valves can<br />
be obtained us sing porcine<br />
valves (top) ) or making a fully<br />
synthetic one (bottom). (d) Raddiography<br />
of a modern m hip prosth hesis. It can<br />
be seen thaat<br />
shape mimicryy<br />
has been done to retrieve the losst<br />
function of the injured hip, in pa articular the<br />
prosthesis rreplaces<br />
the femora<br />
head and ste em. All images arre<br />
freely downloa adable from the web w (search<br />
with www.ggoogle.com,<br />
usingg<br />
the images filte er).<br />
18
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