Barbieri Thesis - BioMedical Materials program (BMM)

Chapter 2 – The role of gels in instructive putties
Table 4. Details on the preparation of injectable pastes.
Putty
Gel/BCP
[%volume ratio]
CMC 2
PLU 1
Table 5. Histmorphometry results in dog model. Statistical comparison is expressed in terms of p–values
and is reported in the text.
Sample
Bone incidence
Controls (212–300 m)
(i.e. BCP granules alone)
8/8 21.7±15.5
CMC 7/8 14.0±11.2
PLU 5/7 18.8±17.3
Bone formation in available area (%)
40
35
30
25
20
15
10
5
0
control CMC PLU
Bone in available space
[%]
Figure 8. Histogram showing the area percentage of bone (calculated on the available space in the
explants). As compared to the controls, the decrease of bone formation in CMC and PLU–based pastes
was not significant. Statistical comparison is expressed in terms of p–values and is reported in the text.
2a.4. Conclusion
In this Addendum we have shown that instructive injectable pastes comprising small
granule size of osteoinductive calcium phosphate ceramic are feasible. Further, the
results presented here confirm the conclusion drawn in Chapter 2: fast dissolvable
polymer binders allow osteoinduction of their putties and injectable pastes.
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