Barbieri Thesis - BioMedical Materials program (BMM)

CChapter
2 – The role r of gels in innstructive
puttie es
Figure 6. Microscopy imaages
of the vari ious groups obttained
by overla apping the fluore escent and
transmitted light images taken
in the same e position. Bonee
started to form m in the control and putties
between 3 aand
6 weeks afteer
the implantation
(xylenol orangee,
red) except in PVA putties. (a) CMC putty.
(b) PLU puttty.
(c) ALG puttyy.
(d) CHI putty. (e) ( PVA putty. (f) BCP alone.
In conclussion,
the factoors
that may influence ecttopic
bone fo ormation in putties
are
(i) the filling
of the avvailable
space e with the gelss
because it delays
or even prevents
the soft tissue
infiltratioon
and angiogenesis,
slowinng
down or sto opping the migration
of
(stem) ceells
into the implant where e they could contact the micro–structu ured BCP
surface aand
(ii) the chhemistry
of th he gels or theeir
degradatio on products since
they
38