Annual Meeting Program - Society of Toxicology

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Society of Toxicology 2008 Program Description (Continued) Abstract # #404 Poster Board Number.......................................305 ASSOCIATION OF THE OGG1 SER326CYS POLYMORPHISM WITH LUNG CANCER RISK IN A TURKISH POPULATION. A. E. Karakaya 1 , B. Karahalil 1 , E. Emerce-Tufan 1 , B. Kocer 2 , S. Han 2 and N. Alkis 3 . 1 Department of Toxicology, Gazi University, Ankara, Turkey, 2 Numune Training and Research Hospital, Ankara, Turkey and 3 Ankara Oncology Training and Research Hospital, Ankara, Turkey. #405 Poster Board Number.......................................306 GENE-ENVIRONMENT INTERACTION BETWEEN HOGG1 SER326CYS POLYMORPHISM AND SMOKING ON LUNG CANCER SUSCEPTIBILITY. R. Yoshida. National institute of Occipational Safety and Health, Kawasaki, Japan. #406 Poster Board Number.......................................307 GENETIC RISK FACTORS IN PROGRESSIVE MASSIVE FIBROSIS IN COAL MINERS. B. Yucesoy 1 , V. J. Johnson 1 , K. Fluharty 1 , M. L. Kashon 2 , J. Slaven 2 , G. Kissling 4 , D. Germolec 5 , V. Vallyathan 3 and M. I. Luster 1 . 1 Toxicology and Molecular Biology Branch, CDC/ NIOSH, Morgantown, WV, 2 Biostatistics and Epidemiology Branch, CDC/NIOSH, Morgantown, WV, 3 Pathology and Physiology Research Branch, CDC/NIOSH, Morgantown, WV, 4 Biostatistics Branch, NIEHS, Research Triangle Park, NC and 5 Toxicology Operations Branch, NIEHS, Research Triangle Park, NC. #407 Poster Board Number.......................................308 RELATIONSHIP BETWEEN ARSENIC- SKIN LESIONS AND THE MET287THR POLYMORPHISM IN AS3MT GENE. O. L. Valenzuela 1 , Z. Drobná 2 , G. G. Garcia-Vargas 3 , V. H. Borja-Aburto 4 , M. Styblo 2 and L. M. Del Razo 1 . 1 Toxicology, Cinvestav-IPN, Mexico D.F, Mexico, 2 Department of Nutrition, and CEMALB, UNC at Chapel Hill, Chapel Hill, NC, 3 Medicina, UJED, Gomez Palacio, Durango, Mexico and 4 IMSS, Mexico, D.F., Mexico. #408 Poster Board Number.......................................309 AMINOLEVULINIC ACID DEHYDRATASE (ALAD) POLYMORPHISM IS ASSOCIATED WITH BLOOD LEAD LEVEL AND HYPERTENSION IN THE NATIONAL HEALTH AND NUTRITION EXAMINATION SURVEY (NHANES III). F. Scinicariello 1,3 , B. A. Fowler 1,3 , A. Yesupriya 2,3 and M. Chang 2,3 . 1 DTEM, ATSDR, Atlanta, GA, 2 NOPHG, CDC, Atlanta, GA and 3 for the CDC/NCI NHANES III Genomics Working Group, Atlanta, GA. #409 Poster Board Number.......................................310 GENETIC VARIANTS IN FOUR METAL- REGULATORY GENES IN AUTISM. S. E. Owens 1 , M. L. Summar 2 , K. K. Ryckman 2 , J. L. Haines 2 and M. Aschner 1 . 1 Pediatrics, Vanderbilt University Medical Center, Nashville, TN and 2 Center for Human Genetics Research, Vanderbilt University Medical Center, Nashville, TN. Abstract # #410 Poster Board Number.......................................311 ASSOCIATIONS BETWEEN THE 5-HTTLPR POLYMORPHISM AND MERCURY FOR MOOD AND BEHAVIOR IN HUMANS. D. Echeverria 1,2 , J. S. Woods 2 , N. Heyer 1 , D. Rholman 3 , F. Farin 2 and T. Li 2 . 1 Center for Public Health Research and Evaluation, Battelle CPHRE, Seattle, WA, 2 Department of Environmental Health, University of Washington, Seattle, WA and 3 3Center for Research on Occupational and Environmental Toxicology, Oregon Health and Science University, Portland, OR. #411 Poster Board Number.......................................312 MULTIPLE LOCI SURROUNDING THE APOE GENE ARE ASSOCIATED WITH APOE LEVELS IN POSTMORTEM ALZHEIMER’S DISEASE BRAIN. L. M. Bekris 1,2 , N. Galloway 2 , T. J. Montine 5 , G. D. Schellenberg 2,3,4 and C. Yu 1,2 . 1 Medicine, University of Washington, Seattle, WA, 2 Geriatric Research, Education and Clinical Center, Veterans Affairs Puget Sound Health Care System, Seattle, WA, 3 Neurology, University of Washington, Seattle, WA, 4 Pharmacology, University of Washington, Seattle, WA and 5 Pathology, University of Washington, Seattle, WA. #412 Poster Board Number.......................................313 IDENTIFICATION OF SINGLE NUCLEOTIDE POLYMORPHISMS IN THE HUMAN AHR FROM SIX ETHNIC POPULATIONS. J. Rowlands 1 , R. Budinsky 1 , B. Gollapudi 1 , K. Drinkwater 2 and M. Storck 2 . 1 The Dow Chemical Company, Midland, MI and 2 Functional Biosciences, Inc., Madison, WI. #413 Poster Board Number.......................................314 N-ACETYLTRANSFERASE 2 GENETIC POLYMORPHISM INCREASES BREAST CANCER RISK AMONG WOMEN SMOKERS IN NEW MEXICO. T. J. Schlierf 1 , D. Yang 2 , M. A. Doll 1 , K. B. Baumgartner 2 and D. W. Hein 1 . 1 Pharmacology and Toxicology, University of Louisville, Louisville, KY and 2 Epidemiology and Population Health, University of Louisville, Louisville, KY. #414 Poster Board Number.......................................315 INVESTIGATION OF THE MECHANISM OF INCREASED N-ACETYLTRANSFERASE 1 (NAT1) EXPRESSION IN ESTROGEN RECEPTOR POSITIVE BREAST CANCER. X. Zhang 1 , D. F. Barker 1 , M. A. Doll 1 , R. C. Martin 1 , J. States 1 , C. M. Klinge 2 and D. W. Hein 1 . 1 Pharmacology and Toxicology, University of Louisville, Louisville, KY and 2 Biochemistry & Molecular Biology, University of Louisville, Louisville, KY. #415 Poster Board Number.......................................316 FUNCTIONAL EFFECT OF N-ACETYLTRANSFERASE 1 (NAT1*10) POLYMORPHISM IN DNA ADDUCT FORMATION AND MUTAGENESIS FOLLOWING EXPOSURE TO AROMATIC AND HETEROCYCLIC AMINE CARCINOGENS. L. M. Millner, J. Bendaly, M. A. Doll, D. F. Barker, J. States and D. W. Hein. Pharmacology and Toxicology, University of Louisville, Louisville, KY. Monday up-to-date information at www.toxicology.org 121
47 th Annual Meeting & ToxExpo Monday Program Description (Continued) Abstract # Abstract # #416 Poster Board Number.......................................317 ROLE OF HUMAN CYTOCHROME P4501A1 AND N-ACETYLTRANSFERASE 2 GENETIC POLYMORPHISM ON THE MUTAGENICITY AND DNA DAMAGE OF THE ENVIRONMENTAL CARCINOGENS 2-AMINO-1-METHYL-6- PHENYLIMIDAZO[4, 5-B]PYRIDINE AND 4- AMINOBIPHENYL. J. Bendaly, S. Zhao, K. J. Metry, M. A. Doll, J. States, N. B. Smith, W. M. Pierce and D. W. Hein. Pharmacology and Toxicology, University of Louisville, Louisville, KY. #417 Poster Board Number.......................................318 ROLE OF HUMAN N-ACETYLTRANSFERASE 2 ACETYLATION POLYMORPHISM IN MUTAGENESIS AND DNA ADDUCT FORMATION BY THE AROMATIC AMINE CARCINOGENS 2-AMINOFLUORENE AND 4-AMINOBIPHENYL. K. J. Metry, M. A. Doll, N. B. Smith, S. Zhao, J. States, W. McGregor, W. M. Pierce and D. W. Hein. Pharmacology and Toxicology, University of Louisville, Louisville, KY. #418 Poster Board Number.......................................319 ANALYSIS OF TRICHLOROETHYLENE METABOLISM IN A GENETICALLY DIVERSE PANEL OF MOUSE INBRED STRAINS. S. Kim 1 , M. C. DeSimone 2,3 , D. Harbourt 2 , G. Boysen 1 , L. Collins 1 , T. M. O’Connell 4 , A. Gold 1 , L. M. Ball 1 , S. Waidyanatha 1 , B. Bradford 1 , D. Threadgill 2,3 and I. Rusyn 1,2 . 1 Envr Sci Eng, UNC- CH, Chapel Hill, NC, 2 Curriculum in Toxicology, UNC-CH, Chapel Hill, NC, 3 Genetics, UNC-CH, Chapel Hill, NC and 4 Devision of Molecular Pharmaceutics, UNC-CH, Chapel Hill, NC. #419 Poster Board Number.......................................320 THE ROLE OF PARAOXONASE (PON1) IN MODULATING TOXICITY OF OP MIXTURES. K. L. Jansen 1 , T. B. Cole 1,2 , W. Li 3 , S. Park 1 , C. E. Furlong 2 and L. G. Costa 1 . 1 Environmental and Occupational Health Sciences, University of Washington, Seattle, WA, 2 Medical Genetics, University of Washington, Seattle, WA and 3 Environmental Health and Occupational Medicine, National Health Research Institutes, Zhunan Town, Taiwan. #420 Poster Board Number.......................................321 SUBCELLULAR LOCALIZATION OF SOLUBLE EPOXIDE HYDROLASE REGULATES ENZYME STABILITY AND ACTIVITY. B. Luo, A. E. Enayetallah and D. F. Grant. Department of Pharmaceutical Sciences, University of Connecticut, Storrs, CT. #421 Poster Board Number.......................................322 EXPLORING GENETIC POLYMORPHISMS IN XENOBIOTIC METABOLIZING ENZYMES THAT MAY AFFECT RESPONSE TO ENVIRONMENTAL TOXICANTS. D. Johns 1 , K. Z. Guyton 2 , B. Sonawane 2 and G. Ginsberg 3 . 1 NCEA, ORD, U.S. EPA, Research Triangle Park, NC, 2 NCEA, ORD, U.S. EPA, Washington, DC and 3 Connecticut Department of Public Health, Hartford, CT. #422 Poster Board Number.......................................323 QUANTITATION OF NAT1, NAT2 AND NAT3 mRNA IN THE RAT: INVESTIGATION OF TISSUE, GENDER AND AGE-SPECIFIC EFFECTS ON GENE EXPRESSION. D. F. Barker, J. M. Walraven, E. H. Ristagno, M. A. Doll and D. W. Hein. Pharmacology and Toxicology, University of Louisville, Louisville, KY. Monday Afternoon, March 17 1:00 PM to 4:30 PM Exhibit Hall Nanotechnology POSTER SESSION: NANOPARTICLES: TESTING APPROACHES, GENO- AND ECOTOXICITY Chairperson(s): Amy Ringwood, University of North Carolina Charlotte, Charlotte, NC and Richard Peterson, University of Wisconsin Madison, Madison, WI. Displayed: 1:00 PM–4:30 PM Attended: 2:45 PM– 4:30 PM #423 Poster Board Number.......................................330 SIZE-DEPENDENT TOXICITY AND UPTAKE OF FLUORESCENT SILICA NANOPARTICLES INTO CELLS. L. Davis 1 , C. M. Grabiniski 1,2 , A. M. Schrand 1 , R. C. Murdock 1 , L. K. Braydich-Stolle 1 , B. Gu 3 , J. J. Schlager 1 and S. M. Hussain 1 . 1 Applied Biotechnology Branch, RHPB, Air Force Research Labs, Wright Patterson, OH, 2 Department of Chemical and Materials Engineering, University Of Dayton, Dayton, OH and 3 Environmental Sciences Division, Oak Ridge National Laboratory, Oak Ridge, TN. #424 Poster Board Number.......................................331 ANALYSIS OF SERUM PROTEIN AND NANOMATERIAL INTERACTIONS AND THE EFFECT ON IN VITRO TOXICOLOGY STUDIES. R. C. Murdock, L. K. Braydich-Stolle, A. M. Schrand, D. R. Mattie, J. J. Schlager and S. M. Hussain. Applied Biotechnology Branch, RHPB, Air Force Research Labs, Wright Patterson, OH. #425 Poster Board Number.......................................332 EFFECTS OF TEMPERATURE, TIME, AND SOLVENT ON NANOPARTICLE AGGLOMERATION. M. C. Moulton, K. O. Yu, A. M. Schrand, D. R. Mattie, J. J. Schlager and S. M. Hussain. Applied Biotechnology Branch, RHPB, Air Force Research Labs, Wright Patterson, OH. #426 Poster Board Number.......................................333 DEVELOPMENTAL TOXICITY OF QUANTUM DOTS IN ZEBRAFISH: INFLUENCE OF SURFACE CHEMISTRY. R. E. Peterson 1,2 , T. C. King Heiden 1 , A. Mangham 3 , P. Wiecinski 1 , K. M. Metz 4 , D. Nesbit 2 , J. A. Pedersen 1,4 , R. J. Hamers 3 and W. Heideman 1,2 . 1 Molecular and Environment Toxicol. Center, UW-Madison, Madison, WI, 2 School of Pharmacy, UW-Madison, Madison, WI, 3 Department of Chemistry, UW-Madison, Madison, WI and 4 Environment Chem. and Technol. Program, UW-Madison, Madison, WI. 122 SOT’s 47 th Annual Meeting
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