Annual Meeting Program - Society of Toxicology

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Society of Toxicology 2008 Program Description (Continued) Abstract # #2254 Poster Board Number.......................................438 GENOTOXICITY SCREENING STEPS UP A GEAR: VALIDATION OF HIGHER THROUGHPUT PROTOCOLS FOR THE GADD45A-GFP GENOTOXICITY ASSAY (GREENSCREEN HC). R. Walmsley, A. W. Knight and L. Birrell. 46 Grafton Street, Gentronix Ltd, Manchester, United Kingdom. #2255 Poster Board Number.......................................439 ASSESSMENT OF THE GENOTOXICITY OF METABOLITES GENERATED BY HEPATOCYTES AND S9 EXTRACTS USING THE GADD45A-GFP GREENSCREEN HC ASSAY. C. Jagger, M. Tate, P. Cahill, C. Hughes, N. Billinton and R. Walmsley. Gentronix Ltd, Manchester, United Kingdom. #2256 Poster Board Number.......................................440 INDEPENDENT VALIDATION OF THE GREENSCREEN GADD45-ALPHA INDICATOR ASSAY USING ONE HUNDRED PROPRIETARY AND NON-PROPRIETARY COMPOUNDS. K. Kolaja 1 , M. Hassani 1 , H. Uppal 1 , S. Kirchner 2 and A. J. Olaharski 1 . 1 Investigative Toxicology, Roche - Palo Alto, Palo Alto, CA and 2 Non-clinical Safety, Hoffman-La Roche, Basel, Switzerland. #2257 Poster Board Number.......................................441 UTILIZATION OF GENE EXPRESSION TECHNOLOGIES IN THE DEVELOPMENT OF A PREDICTIVE ASSAY FOR GENOTOXICITY. S. Lu 1 , B. Jeffy 2 and B. Jessen 1 . 1 Drug safety research and development, Pfizer global research and development, San Diego, CA and 2 Entelos, Foster City, CA. #2258 Poster Board Number.......................................442 OPTIMIZING A MICROTITER PLATE VERSION OF THE YEAST DEL ASSAY FOR THE SCREENING OF CHEMICAL LIBRARIES. Z. Sobol 1 , N. Hontzeas 1 , K. Hafer 2 and R. H. Schiestl 1,2 . 1 Pathology, David Geffen School of Medicine at UCLA, Los Angeles, CA and 2 Radiation Oncology, UCLA, Los Angeles, CA. #2259 Poster Board Number.......................................443 POSITIVE GENOTOXICITY RESULTS DUE TO THE FORMATION OF GENOTOXIC REACTION-PRODUCTS OF THE SOLVENT DMSO WITH CARBOXYLIC/SULFONIC ACID HALIDES. A. Amberg, K. Braun, A. Czich, H. Kauffmann, H. Spirkl, I. Stammberger and G. Troschau. Drug Safety Evaluation, Sanofi-Aventis Deutschland GmbH, Frankfurt, Germany. Sponsor: M. Bonnefoi. Abstract # Thursday Morning, March 20 8:30 AM to 12:00 NOON Ballroom 6C & E POSTER SESSION: PESTICIDE NEUROTOXICITY Chairperson(s): Stephanie Padilla, U.S. EPA, Research Triangle Park, NC. Displayed: 8:30 AM–12:00 NOON Attended: 10:15 AM–12:00 NOON #2260 Poster Board Number.......................................446 COMPARATIVE IN VITRO INHIBITION OF RAT HIPPOCAMPAL MONOACYLGLCYEROL LIPASE BY CHLORPYRIFOS OXON, PARAOXON AND DIISOPROPYLFLUOROPHOSPHATE. A. M. Likins, A. Nallapaneni and C. N. Pope. Physiological Sciences, Oklahoma State University, Stillwater, OK. #2261 Poster Board Number.......................................447 COMPARISON OF ENZYME INHIBITION PATTERNS FOLLOWING DEVELOPMENTAL CHLORPYRIFOS EXPOSURE USING DIFFERENT ADMINISTRATION PARADIGMS. R. L. Carr and C. A. Nail. Center for Environmental Health Sciences, Mississippi State University, Mississippi State, MS. #2262 Poster Board Number.......................................448 ENHANCED STARTLE RESPONSE IN ADULT ZEBRAFISH AFTER EARLY DEVELOPMENTAL CHLORPYRIFOS EXPOSURE: SENSITIVITY OF A RAPID AUTOMATED NEUROBEHAVIORAL TEST. E. D. Levin 1 , D. Cerutti 1 , P. Williams 1 and E. Linney 2 . 1 Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC and 2 Molecular Genetics and Microbiology, Duke University Medical Center, Durham, NC. #2263 Poster Board Number.......................................449 PRENATAL CHLORPYRIFOS EXPOSURE IN MICE IMPAIRS WORKING AND REFERENCE MEMORY IN FEMALES AS ASSESSED BY A NOVEL FORAGING MAZE. S. Agoos 1,2 , D. Butz 2 and W. Porter 2 . 1 Duke University, Durham, NC and 2 UW Madison, Madison, WI. Sponsor: E. Levin. #2264 Poster Board Number.......................................450 CHLORPYRIFOS-OXON INTERFERES WITH AXONOGENESIS IN EMBRYONIC ZEBRAFISH. D. Yang 1 , J. Ladu 2 , K. Buels 1 , H. Lauridsen 1 , R. Tanguay 2 and P. Lein 1 . 1 CROET, Oregon Health & Science University, Portland, OR and 2 Environmental & Molecular Toxicology, Oregon State University, Corvallis, OR. #2265 Poster Board Number.......................................451 CHORPYRIFOS OXON-INDUCED CHANGES IN THIOFLAVIN T BINDING TO THE PERIPHERAL ANIONIC SITE OF HUMAN ACETYLCHOLINESTERASE. L. Sultatos and R. Kaushik. Pharmacology & Physiology, New Jersey Medical School, Newark, NJ. Thursday up-to-date information at www.toxicology.org 283
47 th Annual Meeting & ToxExpo Program Description (Continued) Thursday Abstract # Abstract # #2266 Poster Board Number.......................................452 EXPOSURE OF ZEBRAFISH (DANIO RERIO) EMBRYOS TO DELTAMETHRIN RESULTS IN ALTERATION OF DOPAMINERGIC GENE EXPRESSION AND INCREASED ACTIVITY. A. DeMicco 1 , A. Green 1 , K. R. Cooper 1 , J. R. Richardson 2 and L. A. White 1 . 1 Biochemistry and Microbiology, Rutgers University, New Brunswick, NJ and 2 Toxicology Division, EOHSI, Piscataway, NJ. #2267 Poster Board Number.......................................453 DEVELOPMENTAL DELTAMETHRIN EXPOSURE PRODUCES IMPULSIVE- LIKE BEHAVIOR THAT IS REVERSED BY METHYLPHENIDATE: RELEVANCE TO ADHD. M. Taylor 1 , D. Cory-Slechta 2 and J. Richardson 1 . 1 Joint Graduate Program in Toxicology, Rutgers University and UMDNJ, Piscataway, NJ and 2 Department of Environmental Medicine, University of Rochester, Rochester, NY. #2268 Poster Board Number.......................................454 DELTAMETHRIN AND ESFENVALERATE INHIBIT SPONTANEOUS NETWORK ACTIVITY IN RAT CORTICAL NEURONS IN VITRO. S. M. Losa 2 , J. E. Baldwin 2 , A. M. Johnstone 1 and T. J. Shafer 1 . 1 Neurotoxicology Division, NHEERL, ORD, U.S. EPA, Research Triangle Park, NC and 2 Meredith College, Raleigh, NC. #2269 Poster Board Number.......................................455 MOLECULAR MECHANISMS OF DELTAMETHRIN-INDUCED ALTERATIONS IN DOPAMINE TRANSPORTER EXPRESSION. J. R. Richardson. Environmental and Occupational Medicine, Robert Wood Johnson Medical School, Piscataway, NJ. #2270 Poster Board Number.......................................456 EFFECT OF ORGANOPHOSPHATE ESTER INDUCED DELAYED NEUROPATHY (OPIDN) ON THE NEURONAL CELL BODY. B. S. Jortner, D. Shabb, S. Hancock, J. Hinckley, L. Williams and M. F. Ehrich. Laboratory for Neurotoxicity Studies, Virginia Tech, Blacksburg, VA. #2271 Poster Board Number.......................................457 EFFECTS OF THE ORGANOCHLORINE PESTICIDE DIELDRIN IN THE NEUROENDOCRINE BRAIN OF LARGEMOUTH BASS (Micropterus salmoides). R. E. Weil 1,2 , C. J. Martyniuk 1 , D. S. Barber 1 and N. D. Denslow 1 . 1 Center for Environmental and Human Toxicology, University of Florida, Gainesville, FL and 2 Pharmacology, University of Florida, Gainesville, FL. #2272 Poster Board Number.......................................458 CARBARYL-INDUCED CHOLINESTERASE INHIBITION AND DOSIMETRY IN YOUNG AND ADULT RATS. V. C. Moser 1 , P. M. Phillips 1 , K. L. McDaniel 1 , J. E. Graff 1 , A. B. Lowit 2 , E. Reaves 2 , W. Setzer 3 and D. W. Herr 1 . 1 NTD/ NHEERL/ORD, U.S. EPA, RTP, NC, 2 OPP/OPPTS, U.S. EPA, RTP, NC and 3 NCCT/ORD, U.S. EPA, RTP, NC. #2273 Poster Board Number.......................................459 TIME COURSE OF THE TRANSCRIPTIONAL RESPONSE OF RAT CEREBROCORTICAL TISSUE AFTER ACUTE PYRETHROID EXPOSURE IN VIVO. J. A. Harrill 1 , Z. Li 2 , F. A. Wright 2 and K. M. Crofton 3 . 1 Curriculum in Toxicology, UNC, Chapel Hill, NC, 2 Department of Biostatistics & Carolina Environmental Bioinformatics Research Center, UNC, Chapel Hill, NC and 3 NTD, NHEERL, ORD, U.S. EPA, RTP, NC. #2274 Poster Board Number.......................................460 ACTION OF PYRETHROID INSECTICIDES ON RAT Nav1.6 SODIUM CHANNELS EXPRESSED IN XENOPUS OOCYTES. J. Tan 1 , J. Choi 2 and D. Soderlund 1 . 1 Entomology, Cornell University, Geneva, NY and 2 Neurology, Yale University, New Haven, CT. #2275 Poster Board Number.......................................501 LONG-TERM NEUROBEHAVIORAL CONSEQUENCES OF LOW-LEVEL NEONATAL PARATHION EXPOSURE IN RATS. O. A. Timofeeva 1 , E. D. Levin 1,2,3 , S. Agoos 3 , C. Perraut 1 , F. J. Seidler 2,3 and T. A. Slotkin 2,1,3 . 1 Psychiatry and Behavioral Sciences, Duke University Medical Center, Durham, NC, 2 Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC and 3 Integrated Toxicology and Environmental Health Program, Duke University, Durham, NC. #2276 Poster Board Number.......................................502 DIISOPROPYLPHOSPHOROFLUORIDATE (DFP) INDUCED DIFFERENTIAL mRNA EXPRESSION OF BCL2 IS ONE OF THE MOLECULAR SYMPTOMS OF ORGANOPHOSPHATE INDUCED OPIDN IN HENS. T. V. Damodaran and M. B. Abou-Donia. Medicine and Pharmacology and Cancer biology, Duke University Medical Center, Durham, NC. #2277 Poster Board Number.......................................503 TRANSFER OF NEUROTOXICANTS (MALATHION AND LEAD ACETATE) IN COMBINATION THROUGH IN VITRO BLOOD-BRAIN BARRIER SYSTEMS. P. Balbuena, B. Meldrum, K. Fuhrman, B. Wise and M. Ehrich. College of Veterinary Medicine, Virginia Tech, Blacksburg, VA. #2278 Poster Board Number.......................................504 ORGANOPHOSPHORUS PESTICIDES (OPS) DO NOT INTERACT DIRECTLY WITH AIRWAY NERVES TO CAUSE NEURONAL M2 RECEPTOR DYSFUNCTION. D. Bruun 1 , B. Proskocil 2 , A. Fryer 2 and P. J. Lein 1 . 1 CROET, Oregon Health & Science University, Portland, OR and 2 Physiology and Pharmacology, Oregon Health & Science University, Portland, OR. #2279 Poster Board Number.......................................505 SPECTRAL EVALUATION OF ELECTROGRAPHIC SEIZURES AFTER EXPOSURE TO ORGANOPHOSPHORUS COMPOUNDS. M. Furtado 1 , L. Lumley 2 , J. Waterhouse 1 , S. Lichtenstein 1 , B. Litwack 1 , T. Herbert 1 , K. Clements 1 , C. Robison 2 and D. Yourick 1 . 1 Headquarters, Walter Reed Army Institute of Research, Silver Spring, MD and 2 U.S. Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, MD. Sponsor: J. Yourick. 284 SOT’s 47 th Annual Meeting
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Annual Meeting Sponsors (as of Janu
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