Annual Meeting Program - Society of Toxicology

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Society of Toxicology 2008 Program Description (Continued) Abstract # #2155 Poster Board Number.......................................253 PARTIAL PHENOTYPIC AND FUNCTIONAL CHARACTERIZATION OF LEUKOCYTES FROM RYR1 R163C MH MICE. S. R. Goth 1,2 , S. Tong 2 , B. T. Yuen 2 , P. D. Allen 3 and I. N. Pessah 1,2 . 1 Center for Children’s Environmental Health, UC Davis, Davis, CA, 2 Department of Molecular Biosciences, UC Davis, Davis, CA and 3 Department of Anesthesia, Brigham and Women’s Hospital, Boston, MA. Thursday Morning, March 20 8:30 AM to 12:00 NOON Ballroom 6C & E POSTER SESSION: AHR MECHANISMS Chairperson(s): Richard Pollenz, University of South Florida, Tampa, FL and Wade Powell, Kenyon College, Gambier, OH. Displayed: 8:30 AM–12:00 NOON Attended: 10:15 AM–12:00 NOON #2156 Poster Board Number.......................................254 ROLE OF THE CULLIN 4B, E6AP AND MDM2 UBIQUITIN E3 LIGASE ENZYMES IN LIGAND-DEPENDENT AND INDEPENDENT DEGRADATION OF THE AH RECEPTOR. R. S. Pollenz. Cell Biology, Microbiology and Molecular Biology, University of South Florida, Tampa, FL. #2157 Poster Board Number.......................................255 ROLE OF DNA BINDING AND DIMERIZATION WITH ARNT IN THE LIGAND-INDUCED DEGRADATION OF THE AH RECEPTOR. R. Buzzeo, E. J. Dougherty and R. S. Pollenz. Cell Biology, Microbiology and Molecular Biology, University of South Florida, Tampa, FL. #2158 Poster Board Number.......................................256 HSP90 DISPLACEMENT DURING LIGAND- DEPENDENT TRANSFORMATION OF THE ARYL HYDROCARBON RECEPTOR. A. Soshilov and M. S. Denison. Environmental Toxicology, UCDavis, Davis, CA. #2159 Poster Board Number.......................................257 IDENTIFICATION OF MURINE AHR RESIDUES THAT MAY A PLAY ROLE IN SIGNAL TRANSDUCTION THROUGH PHOSPHORYLATION. D. P. Vorojeikina, S. K. Park and T. A. Gasiewicz. Environmental medicine, School of Medicine and Dentistry University of Rochester, Rochester, NY. #2160 Poster Board Number.......................................258 EPIDERMAL GROWTH FACTOR RECEPTOR PATHWAY BLOCKS ARYL HYDROCARBON RECEPTOR-MEDIATED TRANSCRIPTION AND DIFFERENTIATION IN EPIDERMAL KERATINOCYTES. C. H. Sutter 1 , H. Yin 2 , Y. Li 2 , M. S. Jennifer 2 and T. R. Sutter 1 . 1 Feinstone Center for Genomic Research, University of Memphis, Memphis, TN and 2 Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD. Abstract # #2161 Poster Board Number.......................................259 SERINE 395, A SITE IMPORTANT FOR TRANSCRIPTIONAL ACTIVITY IN THE MOUSE ARYL HYDROCARBON RECEPTOR (AHR), IS PHOSPHORYLATED BY PROTEIN KINASE A. B. Kobielush 1 , G. D. Minsavage 1 , D. Vorojeikina 1 , M. L. Easterling 2 , A. Friedman 1 and T. A. Gasiewicz 1 . 1 Environmental Medicine, University of Rochester, Rochester, NY and 2 Bruker Daltonics, Billerica, MA. #2162 Poster Board Number.......................................260 IN VIVO LEFLUNOMIDE EXPOSURE MIMICS THE EFFECTS OF TCDD IN AN AHR-DEPENDENT MANNER. K. S. Saili, L. K. Mathew, S. Sengupta, N. I. Kerkvliet, S. K. Kolluri and R. L. Tanguay. Department of Environmental & Molecular Toxicology, Environmental Health Sciences Center, Oregon State University, Corvallis, OR. #2163 Poster Board Number.......................................301 LIGAND-DEPENDENT DIFFERENCES OF DNA BINDING BY AHR-ARNT COMPLEXES VERSUS AHR-ARNT2 COMPLEXES IN VITRO. E. J. Dougherty and R. S. Pollenz. Cell Biology, Microbiology and Molecular Biology, University of South Florida, Tampa, FL. #2164 Poster Board Number.......................................302 RELATIVE POTENCIES OF INDIVIDUAL DIOXIN-LIKE COMPOUNDS FOR IN VITRO CYTOCHROME P450 1A1 TRANSACTIVATION OF ARYL HYDROCARBON RECEPTOR FROM BAIKAL SEAL. H. Iwata 1 , E. Kim 1 , T. Suda 1 , S. Tanabe 1 and E. A. Petrov 2 . 1 Center for Marine Environmental Studies, Ehime University, Matsuyama, Japan and 2 The Eastern-Siberian Scientific and Production Fisheries Center, Ulan- Ude, Russian Federation. #2165 Poster Board Number.......................................303 RESPONSIVENESS OF A XENOPUS LAEVIS CELL LINE TO THE ARYL HYDROCARBON RECEPTOR LIGAND 6-FORMYLINDOLO[3, 2-b]CARBAZOLE (FICZ). L. B. Laub 1 , B. D. Jones 2 and W. H. Powell 1 . 1 Biology Department, Kenyon College, Gambier, OH and 2 Mathematics Department, Kenyon College, Gambier, OH. #2166 Poster Board Number.......................................304 DISTINCT REGULATION OF THE ARYL HYDROCARBON RECEPTOR ACTIVITY BY DIFFERENT LIGANDS. S. Luecke 1 , K. Gradin 2 , L. Poellinger 2 , A. Rannug 1 and M. Backlund 1 . 1 Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden and 2 Department of Cell and Molecular Biology, Karolinska Institutet, Stockholm, Sweden. #2167 Poster Board Number.......................................305 LIGAND SPECIFICITY IN MODULATING ARYL HYDROCARBON RECEPTOR DNA BINDING. D. DeGroot, Y. Song, S. R. Rushing and M. S. Denison. Environmental Toxicology, University of California, Davis, Davis, CA. #2168 Poster Board Number.......................................306 NEWSPAPERS AND NEWSPAPER INK CONTAIN AGONISTS FOR THE AH RECEPTOR. B. Zhao, J. E. Bohonowych, G. He and M. S. Denison. Environmental Toxicology, University of California, Davis, Davis, CA. Thursday up-to-date information at www.toxicology.org 275
47 th Annual Meeting & ToxExpo Program Description (Continued) Thursday Abstract # Abstract # #2169 Poster Board Number.......................................307 ARYL-HYDROCARBON RECEPTOR (AHR), AGING AND IMMUNITY. L. B. Steppan, D. G. Farrer, D. Pham and N. I. Kerkvliet. Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR. #2170 Poster Board Number.......................................308 ARYL HYDROCARBON RECEPTOR (AHR) REPRESSES ACUTE PHASE RESPONSE GENE EXPRESSION IN A DNA-BINDING INDEPENDENT MANNER. R. D. Patel, A. Kusnadi, C. A. Flaveny and G. H. Perdew. Department of Veterinary & Biomedical Science, The Pennsylvania State University, University Park, PA. #2171 Poster Board Number.......................................309 COMBINATION OF INFLAMMATORY SIGNALING AND AN AHR LIGAND LEADS TO SYNERGISTIC INDUCTION OF IL-6. B. DiNatale, B. Hollingshead and G. H. Perdew. Department of Veterinary & Biomedical Science, The Pennsylvania State University, University Park, PA. Thursday Morning, March 20 8:30 AM to 12:00 NOON Ballroom 6C & E POSTER SESSION: CHEMOPREVENTION Chairperson(s): Silvia Barros, University of Sao Paulo, Sao Paulo, Brazil. Displayed: 8:30 AM–12:00 NOON Attended: 8:30 AM–10:15 AM #2172 Poster Board Number.......................................311 USE OF COMPLEMENTARY AND ALTERNATIVE MEDICINES DURING BREAST CANCER TREATMENT – POTENTIAL INTERACTIONS WITH AROMATASE INHIBITORS. M. B. van Duursen 1 , P. M. Martines 1 , S. M. Nijmeijer 1 , P. C. de Jong 2 and M. van den Berg 1 . 1 Institute for Risk Assessment Sciences (IRAS), Utrecht University, Utrecht, Netherlands and 2 Department of Internal Medicine, St Antonius Hospital, Nieuwegein, Netherlands. #2173 Poster Board Number.......................................312 4-NEROLIDYLCATHECOL (4NC), A COMPOUND FROM POTHOMORPHE UMBELLATA, AS A CYTOTOXIC AGENT FOR HUMAN METASTATIC MELANOMA CELLS. S. B. Barros, T. C. Sawada, C. A. Brohem, R. M. Massaro, D. R. Rivelli, R. L. Almeida, C. D. Ropke, V. V. Silva and S. S. Maria-Engler. Clinical Chemistry and Toxicology, University of São Paulo, São Paulo, SP, Brazil. #2174 Poster Board Number.......................................313 DECREASED INCIDENCES OF NEOPLASMS AND NON-NEOPLASTIC LESIONS IN F344/N RATS AND B6C3F1 MICE FED MILK THISTLE EXTRACTS FOR TWO YEARS. B. Singh, A. Nyska, A. Roycroft, D. E. Malarkey and J. Dunnick. Environmental Toxicology Program, NIEHS, Research Triangle Park, NC. #2175 Poster Board Number.......................................314 SAPONINS DERIVED FROM ROOTS OF PLATYCODON GRANDIFLORUM INHIBIT AP-1 TRANSACTIVATION AND CELL TRANSFORMATION IN BEAS-2B HUMAN BRONCHIAL EPITHELIAL CELLS. P. Hyejin 1,2 and H. Jeong 1,2 . 1 Pharmacy, Chosun University, Kwangju, South Korea and 2 Research Center for Proteineous Materials, Chosun University, Gwangju, South Korea. #2176 Poster Board Number.......................................315 EFFECTS OF THE COFFEE DITERPENE KAHWEOL ON THE INHIBITION OF PROLIFERATION AND INDUCTION OF APOPTOSIS IN HUMAN LUNG ADENOCARCINOMA A549 CELLS. K. H. Hyunggyun 1,2 and H. Jeong 1,2 . 1 Pharmacy, Chosun University, Kwangju, South Korea and 2 Research Center for Proteineous Materials, Chosun University, Gwangju, South Korea. #2177 Poster Board Number.......................................316 SAPONINS ISOLATED FROM THE ROOT OF PLATYCODI RADIX INHIBITS THE INVASION AND MIGRATION OF HT1080 HUMAN FIBROSARCOMA CELLS VIA THE INHIBITION OF MMP-2 ACTIVATION AND DOWN REGULATION OF MMP-9 AND MT1- MMP. S. Hwang 1,2 , J. Choi 1,2 , K. Lee 1,2 , Y. Chung 3 and H. Jeong 1,2 . 1 Pharmacy, Chosun University, Kwangju, South Korea, 2 Research Center for Proteineous Materials, Chosun University, Gwangju, South Korea and 3 Division of Food Science, Jinju International University, Jinju, South Korea. #2178 Poster Board Number.......................................317 BIS[3’-(5-BROMOINDOLYL)]METHANE INDUCES KRüPPEL-LIKE FACTOR 4-DEPENDENT ACTIVATION OF P21 IN COLON CANCER CELLS EXPRESSING WILD-TYPE OR MUTANT P53. S. Liu 1 , S. Cho 1 , S. Chintharlapalli 1 , M. Abdelrahim 2,3 , S. Papineni 4 , J. Guo 1 , P. Lei 1 and S. Safe 1,4 . 1 Institute of Biosciences and Technology, Houston, TX, 2 MD Anderson Cancer Center, Orlando, FL, 3 Department of Pathology, Orlando Regional Healthcare, Orlando, FL and 4 Veterinary Physiology and Pharmacology, Texas A&M University, College Station, TX. #2179 Poster Board Number.......................................318 DIHYDROARTEMISININ SUPPRESSES PMA-MEDIATED MATRIX METALLOPROTEINASE-9 GENE ACTIVATION THROUGH DOWN- REGULATING NUCLEAR FACTOR-KAPPAB AND C-JUN. H. YongPil 1,2 and H. Jeong 1,2 . 1 Pharmacy, Chosun University, Kwangju, South Korea and 2 Research Center for Proteineous Materials, Chosun University, Gwangju, South Korea. #2180 Poster Board Number.......................................319 EPIGALLOCATECHIN-3-GALLATE IS A NOVEL HSP90 INHIBITOR. Z. Yin, E. Henry and T. Gasiewicz. Department of Environmental Medicine, University of Rochester Medical Center, Rochester, NY. 276 SOT’s 47 th Annual Meeting
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Annual Meeting Program - Society of Toxicology

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