Annual Meeting Program - Society of Toxicology

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Society of Toxicology 2008 Program Description (Continued) Abstract # #2229 Poster Board Number.......................................411 SAFETY ASSESSMENT OF GLYPHOSATE ACETYLTRANSFERASE (GAT4601) PROTEIN. B. Delaney 1 , J. Zhang 1 , G. Carlson 1 , T. Davis 1 , J. Schmidt 1 , B. Stagg 1 , B. Comstock 1 , A. Babb 2 , C. Finlay 3 , R. Cressman 4 , G. Ladics 4 , A. Cogburn 4 , D. Siehl 5 , L. Bardina 6 , H. Sampson 6 and Y. Han 7 . 1 Pioneer Hi-Bred International, Inc., Johnston, IA, 2 Charles River Laboratories, Redfield, AR, 3 DuPont Haskell Laboratory, Newark, DE, 4 DuPont Agriculture and Nutrition, Wilmington, DE, 5 Pioneer Hi-Bred International, Inc., Verdia Campus, Redwood City, CA, 6 Department of Pediatrics and Immunobiology, Mount Sinai School of Medicine, New York and 7 Sungkyunkwan University School of Medicine, Seoul, South Korea. #2230 Poster Board Number.......................................412 SUBCHRONIC DIETARY TOXICITY OF HIGH OLEIC SOYBEAN EVENT DP-3Ø5423-1 NUTRITIONALLY- MODIFIED USING GENE SUPPRESSION TECHNOLOGY. C. D. Sanders 1 , L. M. Appenzeller 1 , S. M. Munley 2 , L. A. Malley 2 , D. Hoban 2 , G. P. Sykes 2 and B. Delaney 1 . 1 Pioneer Hi-Bred Int’l., Inc., Johnston, IA and 2 DuPont Haskell Laboratory, Newark, DE. #2231 Poster Board Number.......................................413 LOW DOSE DIETARY GENISTEIN NEGATES THE THERAPEUTIC EFFECT OF TAMOXIFEN. M. Du 1 , J. A. Hartman 2 , H. Song 2 , Y. H. Ju 3 and W. G. Helferich 2,1 . 1 Division of Nutritional Sciences, University of Illinois at Urbana-Champaign, Urbana, IL, 2 Department of Food Science and Human Nutrition, University of Illinois at Urbana-Champaign, Urbana, IL and 3 Department of Human Nutrition, Foods and Exercise, Virginia Polytechnic Institute and State University, Blacksburg, VA. #2232 Poster Board Number.......................................414 SAFETY AND EFFICACY EVALUATION OF PEDIOCOCCUS ACIDILACTICI AS AN ORAL PROBIOTIC. B. Magnuson 1 , G. Lala 1 , J. Rindos 1 , G. Vo 1 , J. J. Lin 2 and U. Babu 3 . 1 Department of Nutr and Food Sci, University of Maryland, College Park, MD, 2 Imagilin Technologies, Potomac, MD and 3 CFSAN, Food and Drug Administration, Beltsville, MD. #2233 Poster Board Number.......................................415 SUBCHRONIC DIETARY TOXICITY OF SOYBEAN EVENT DP-356Ø43-5 GENETICALLY-MODIFIED USING A NOVEL GENE SHUFFLING TECHNOLOGY. L. M. Appenzeller 1 , R. Essner 1 , S. M. Munley 2 , L. A. Malley 2 , D. Hoban 2 , G. P. Sykes 2 and B. Delaney 1 . 1 Pioneer Hi-Bred Int’l., Inc., Johnston, IA and 2 DuPont Haskell Laboratory, Newark, DE. #2234 Poster Board Number.......................................416 NON-CARIOGENICITY OF HYDROGENATED POLYDEXTROSE, A SYNTHETIC LOW-CALORIE POLYSACCHARIDE SUGAR REPLACER IN FOODS. J. C. Griffiths 1 and M. H. Auerbach 2 . 1 Burdock Group, Vero Beach, FL and 2 Danisco A/S, Elmsford, NY. Abstract # #2235 Poster Board Number.......................................417 RAW264.7 MACROPHAGE CELLS - AN IN VITRO ALTERNATIVE FOOD SAFETY TESTING PLATFORM COMPATIBLE WITH VARIOUS FOOD TYPES AND FOOD-BORNE TOXINS. W. H. Tolleson 1 and L. S. Jackson 2 . 1 Division of Biochemical Toxicology, FDA-NCTR, Jefferson, AR and 2 National Center for Food Safety and Technology, FDA-CFSAN, Summit-Argo, IL. #2236 Poster Board Number.......................................418 DIETARY FLAVONOIDS SULFATION BY HUMAN SULFOTRANSFERASES. C. Huang and G. Chen. Physiological Sciences, Oklahoma State University, Stillwater, OK. #2237 Poster Board Number.......................................419 SAFETY ASSESSMENT OF LACTERMIN®, A WHEY EXTRACT. A. Dyer 2 , G. Burdock 1 , I. Carabin 1 and L. Read 2 . 1 Burdock Group, Orlando, FL and 2 TGR BioSciences Pty. Ltd, Thebarton, SA, Australia. #2238 Poster Board Number.......................................420 AFLATOXIN EXPOSURE DECREASES SERUM LEVELS OF VITAMINS A & E IN GHANAIANS AT HIGH RISK FOR AFLATOXICOSIS. L. Tang 1 , L. Xu 1 , E. Afriyie- Gyawu 2 , P. Wang 1 , Y. Tang 1 , Z. Wang 1 , H. J. Huebner 2 , N. A. Ankrah 3 , D. Ofori-Adjei 3 , W. O. Ellis 4 , P. E. Jolly 5 , J. H. Williams 6 , J. S. Wang 1 and T. D. Phillips 2 . 1 Texas Tech University, Lubbock, TX, 2 Texas A&M University, College Station, TX, 3 University of Ghana, Accra, Ghana, 4 KNUST, Kumasi, Ghana, 5 University of Alabama, Birmingham, AL and 6 University of Georgia, Griffin, GA. #2239 Poster Board Number.......................................421 SEX DIFFERENCES IN APPARENT ADAPTATION TO IMMUNOTOXICITY OF DEOXYNIVALENOL. X. Wu 1 , M. Kohut 2 , J. Cunnick 3 and S. Hendrich 1 . 1 Food Science and Human Nutrition, Iowa State University, Ames, IA, 2 Kinesiology, Iowa State University, Ames, IA and 3 Animal Science, Iowa State University, Ames, IA. #2240 Poster Board Number.......................................422 FUMONISIN B1 EXPOSURE PHENOCOPIES CHOLESTEROL DEPRIVATION IN C. ELEGANS. M. McElwee 1,2 , A. Wise 1,2 , W. A. Boyd 1 and J. H. Freedman 1,2 . 1 Laboratory of Molecular Toxicology, NIEHS, Research Triangle Park, NC and 2 Nicholas School of the Environment, Duke University, Durham, NC. #2241 Poster Board Number.......................................423 THE PI3K/AKT SIGNALING PATHWAY MEDIATES THE INDUCTION OF CHOLESTEROL BIOSYNTHESIS GENES BY a-CHACONINE IN INTESTINAL EPITHELIAL CELLS. A. Peijnenburg 1 , T. Mandimika 1,2 , H. Baykus 1 , J. Poortman 1 , H. Kuiper 1 and C. Garza 3 . 1 RIKILT-Institute of Food Safety, Wageningen, Netherlands, 2 Division of Nutritional Sciences, Cornell University, Ithaca, NY and 3 Office of the Provost, Boston College, Chestnut Hill, MA. Sponsor: M. Heneweer. Thursday up-to-date information at www.toxicology.org 281
47 th Annual Meeting & ToxExpo Program Description (Continued) Thursday Abstract # Abstract # Thursday Morning, March 20 8:30 AM to 12:00 NOON Ballroom 6C & E POSTER SESSION: HIGH-THROUGHPUT, HIGH CONTENT APPROACHES TO ASSESSING GENOTOXICITY Chairperson(s): Andrew Olaharski, Roche Palo Alto, Palo Alto, CA and Raymond Kemper, Boehringer Ingelheim Pharmaceuticals Inc, Ridgefield, CT. Displayed: 8:30 AM–12:00 NOON Attended: 8:30 AM–10:15 AM #2242 Poster Board Number.......................................426 HIGH CONTENT DNA DAMAGE ASSAY: SIMULTANEOUS MEASUREMENT OF H2AX PHOSPHORYLATION, ATM ACTIVATION, AND DNA CONTENT COMBINED WITH LIVE CELL ANALYSIS. E. Holden 1 , E. Luther 1 and Z. Darzynkiewicz 2 . 1 Strategic Research Development, CompuCyte Corp., Cambridge, MA and 2 Brander Cancer Institute, New York Medical College, Valhalla, NY. #2243 Poster Board Number.......................................427 TRACING MICRONUCLEI BY FLUORESCENT LIVE CELL IMAGING ANALYSIS. M. Honma 1 , Y. Takashima 2 , M. Yasui 1 , N. Koyama 1 , T. Koizumi 1 , M. Sakuraba 1 , H. Sakamoto 1 , K. Sugimoto 3 and M. Hayashi 1 . 1 Division of Genetics and Mutagenesis, National Institute of Health Sciences, Tokyo, Japan, 2 Research Center for Radiation Emergency Medicine, National Institute of Radiological Sciences, Chiba, Japan and 3 Division of Biosciences and informatics, Osaka Prefecture University, Osaka, Japan. Sponsor: M. Ema. #2244 Poster Board Number.......................................428 IN VITRO MICRONUCLEI SCORED BY FLOW CYTOMETRY: AN INTERNATIONAL, MULTI-LABORATORY TRIAL. S. Dertinger 1 , S. Bryce 1 , S. Avlasevich 1 , J. Bemis 1 , M. Lukamowicz 2 , A. Elhajouji 2 , F. Van Goethem 3 , M. De Boeck 3 , D. Beerens 3 , H. Aerts 3 , J. Van Gompel 3 , J. Collins 4 , P. Ellis 4 , A. White 4 and A. Lynch 4 . 1 Litron Laboratories, Rochester, NY, 2 Novartis Pharmacology AG, Basel, Switzerland, 3 Johnson & Johnson Pharmaceutical R&D, Division of Janssen, Beerse, Belgium and 4 GlaxoSmithKline, Ware, Hertfordshire, United Kingdom. #2245 Poster Board Number.......................................429 TIME-RELATED PROFILES OF MICRONUCLEATED PCES AND NCES IN BOTH BLOOD AND BONE MARROW AS MEASURED BY MICROSCOPY AND FLOW CYTOMETRY. Y. Xu 1 , D. Torous 2 , E. Chacon 1 , B. Hsu 1 , K. Butler 1 , C. Marsh 1 , A. Soufal 1 , D. Montague 1 , S. Dertinger 2 and T. E. Lawlor 1 . 1 Genetic & Molecular Toxicology, Covance Laboratories, Vienna, VA and 2 Litron Laboratories, Rochester, NY. #2246 Poster Board Number.......................................430 AUTOMATED FLOW CYTOMETRIC DETECTION OF MURINE PERIPHERAL BLOOD MICRONUCLEATED ERYTHROCYTES USING NO-WASH, ROOM-TEMPERATURE GTOX FLOW KIT. E. Gautherot, F. Gaille, M. Herbert, A. van Agthoven, F. Malergue, F. A. Montero and J. Wolfers. Beckman Coulter Immunotech, Marseille, France. Sponsor: J. Allen. #2247 Poster Board Number.......................................431 DEVELOPMENT OF AUTOMATED IN VITRO MICRONUCLEUS AND CYTOTOXICITY SCREENING ASSAYS. Y. Ovechkina, P. T. Nguyen, R. Keyser and C. O’Day. MDS Pharmacology Services, Bothell, WA. Sponsor: L. King. #2248 Poster Board Number.......................................432 ANEUGENIC COMPOUNDS INCREASE MICRONUCLEUS FREQUENCIES IN MONONUCLEATED CELLS IN THE CB MICRONUCLEUS TEST. A. Poth and S. Bohnenberger. Genetic Toxicology and Alternative Methods, RCC Ltd, Rossdorf, Germany. #2249 Poster Board Number.......................................433 USING KINASE SELECTIVITY PROFILES TO PREDICT IN VITRO MICRONUCLEUS ASSAY RESULTS. A. J. Olaharski 1 , N. Gonzaludo 2 , H. Bitter 2 , S. Kirchner 4 , G. Fischer 4 , D. Goldstein 3 and K. Kolaja 1 . 1 Investigative Toxicology, Roche, Palo Alto, CA, 2 Group research information, Roche, Palo Alto, CA, 3 Medicinal Chemistry, Roche, Palo Alto, CA and 4 Non-clinical drug safety, Roche, Basel, Switzerland. #2250 Poster Board Number.......................................434 AUTOMATED IN VITRO MICRONUCLEUS TESTING OF NATURAL COMPOUNDS IN CORRELATION WITH HYDROGEN PEROXIDE DETECTION. G. Pappa, T. Woehrle and M. Toeroek. R&D Human Nutrition and Health, Safety, DSM Nutritional Products Ltd, Basel, Switzerland. #2251 Poster Board Number.......................................435 VALIDATION AND OPTIMIZATION OF THE IN VITRO MICRONUCLEUS ASSAY IN HUMAN LYMPHOCYTES. C. S. Farabaugh, C. A. Middendorf, D. J. Roberts and L. F. Stankowski. Covance Laboratories, Inc, Vienna, VA. Sponsor: B. Fisher. #2252 Poster Board Number.......................................436 AN IMPROVED FLOW CYTOMETRY- BASED UNSCHEDULED DNA SYNTHESIS (UDS) ASSAY. J. Tao 1 , C. Kirk 1 , L. F. Pratt 1 , G. M. Williams 2 and G. L. DeGeorge 1 . 1 MB Research Laboratories, Spinnerstown, PA and 2 Department of Pathology, NY Medical College, Valhalla, NY. #2253 Poster Board Number.......................................437 HIGH CONTENT SCREENING CELL-BASED ASSAYS FOR IN VITRO GENOTOXICITY MEASUREMENTS. B. S. Mandavilli and R. N. Ghosh. Research and Development, Thermo Fisher Scientific, Rockford, IL. Sponsor: A. Barchowsky. 282 SOT’s 47 th Annual Meeting
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Annual Meeting Sponsors (as of Janu
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