Annual Meeting Program - Society of Toxicology

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Society of Toxicology 2008 Program Description (Continued) Abstract # #1144 Poster Board Number.......................................544 MODULATION OF INTRATESTICULAR FUNCTION IN F-344 RATS BY BENZO(A) PYRENE. A. E. Archibong 1 , M. S. Niaz 1 , C. M. Brooks 1 , S. I. Roberson 1 , A. Ramesh 2 and D. D. Lunstra 3 . 1 Obstetrics & Gynecology, Meharry Medical College, Nashville, TN, 2 Cancer Biology, Meharry Medical College, Nashville, TN and 3 Animal Reproduction Division, USDA Meat Animal Research Center, Clay Center, NE. #1145 Poster Board Number.......................................545 EVALUATION OF OVOTOXICITY INDUCED BY 7, 12-DIMETHYLBENZ[A]ANTHRACENE AND ITS 3, 4-DIOL METABOLITE UTILIZING A RAT IN VITRO OVARIAN CULTURE SYSTEM. Y. Igawa 1,3 , I. Sipes 1 and P. B. Hoyer 2 . 1 Pharmacology, University of Arizona, Tucson, AZ, 2 Physiology, University of Arizona, Tucson, AZ and 3 Biopharma Center, Asubio Pharmacology Co., Ltd., Gunma, Japan. #1146 Poster Board Number.......................................546 CIGARETTE SMOKE AND BENZO(A) PYRENE CAUSE FOLLICLE LOSS IN VIVO AND IN VITRO AT PHYSIOLOGICALLY RELEVANT CONCENTRATIONS. A. Mulligan Tuttle and W. G. Foster. McMaster University, Hamilton, ON, Canada. #1147 Poster Board Number.......................................547 GLUCOCORTICOID RECEPTOR ACTIVATION RESTRAINS THE GROWTH- PROMOTING EFFECT OF TCDD ON MAMMARY EPITHELIAL CELLS. T. Wang 1 , B. Lawrence 2 and B. A. Vorderstrasse 1 . 1 Pharmaceutical Sciences, Washington State University, Pullman, WA and 2 Department of Environmental Medicine, University of Rochester, Rochester, NY. #1148 Poster Board Number.......................................548 EFFECTS OF MOTORCYCLE EXHAUST AND COTREATMENT WITH VITAMIN E ON SPERM CONTENT AND INTERLEUKIN-6 EXPRESSION IN RAT TESTIS. T. Ueng, Y. Liu and P. Chan. Institute of Toxicology, National Taiwan University, Taipei, Taiwan. #1149 Poster Board Number.......................................549 DOES BUTYL ISOCYANATE PLAY A ROLE IN THE TUBULIN DEPOLYMERIZING ACTION OF THE FUNGICIDE BENOMYL? A. Rodriguez and M. G. Miller. Environmental Toxicology, UC Davis, Davis, CA. #1150 Poster Board Number.......................................550 ASSESSMENT OF THE EFFECTS OF MONOETHYLHEXYLPHTHALATE (MEHP) AND MONOBUTYL PHTHALATE (MBP) ON GENE EXPRESSION IN FETAL RAT TESTES EXPLANT CULTURES BY TRANSCRIPTION PROFILING. S. Plummer 1 , F. Chauvigne 2 , B. Jégou 2 and C. Elcombe 1 . 1 CXR Biosciences Ltd, Dundee, United Kingdom and 2 Inserm, Campus de beaulieu, Rennes, France. Abstract # #1151 Poster Board Number.......................................551 THE EFFECT OF INDIVIDUAL VS GROUP HOUSING ON GROWTH, ONSET OF PUBERTY, AND REPRODUCTIVE ORGAN DEVELOPMENT IN MICE. S. S. Dimond 1,2 . 1 Department of Environmental Health and Toxicology, State University of New York at Albany, Albany, NY and 2 Environmental, Health and Safety Department, SABIC Innovative Plastics, Bedford, NH. #1152 Poster Board Number.......................................552 EFFECT OF METHOXYCHLOR METABOLITE HPTE IN RAT OVARIAN GRANULOSA CELLS. C. N. Harvey 1 , M. Esmail 2 , M. Uzumcu 1,2 and R. Zachow 3 . 1 Joint Graduate Program of Toxicology, Rutgers University/UMDNJ, Piscataway, NJ, 2 Department of Animal Sciences, Rutgers University, New Brunswick, NJ and 3 Department of Physiology and Biophysics, Robert Wood Johnson Medical School, Piscataway, NJ. #1153 Poster Board Number.......................................553 CELL CYCLE REGULATORS IN MOUSE OVARIAN ANTRAL FOLLICLES ARE ALTERED BY METHOXYCHLOR EXPOSURE. R. K. Gupta, H. H. Yao and J. A. Flaws. Veterinary Biosciences, University of Illinois, Urbana, IL. #1154 Poster Board Number.......................................554 DOSE DEPENDENT EFFECTS OF SERTOLI CELL TOXICANTS 2, 5-HEXANEDIONE, CARBENDAZIM, AND MONO-(2- ETHYLHEXYL) PHTHALATE IN ADULT RAT TESTIS. J. S. Moffit, B. H. Bryant, C. L. Auriemma, R. T. Glenn, H. Yamasaki, M. A. Sandrof, S. J. Hall and K. Boekelheide. Pathology & Laboratory Medicine, Brown University, Providence, RI. #1155 Poster Board Number.......................................555 REPRODUCTIVE AND DEVELOPMENTAL EFFECTS OF GESTATIONAL EXPOSURE TO PERFLUOROOCTANOIC ACID IN MALE CD-1 MICE. J. P. Stanko 1 , E. P. Hines 1 , S. S. White 2,1 , G. R. Klinefelter 1 , L. F. Strader 1 , J. D. Suarez 1 and S. E. Fenton 1 . 1 NHEERL, U.S. EPA, Research Triangle Park, NC and 2 Curriculum in Toxicology, University of North Carolina, Chapel Hill, NC. #1156 Poster Board Number.......................................556 ADULT OUTCOMES OF GESTATIONAL OR ADULT EXPOSURE TO PERFLUOROOCTANIC ACID (PFOA) IN FEMALE CD-1 MICE. E. P. Hines 1 , S. S. White 2 , J. P. Stanko 1 and S. E. Fenton 1 . 1 Reproductive Toxicology, DBB, ORD, NHEERL, U.S. EPA, Durham, NC and 2 Curriculum in Toxicology, UNC, Chapel Hill, NC. #1157 Poster Board Number.......................................557 EVALUATION OF TWO- GENERATION REPRODUCTIVE TOXICITY OF FLAME RETARDANT HEXABROMOCYCLODODECANE (HBCD) IN RATS. M. Ema 1 , S. Fujii 2 , M. Hirata-Koizumi 1 and M. Matsumoto 1 . 1 Division of Risk Assessment, National Insitute of Health Sciences, Tokyo, Japan and 2 Safety Research Institute for Chemical Compounds Co., Ltd., Sapporo, Japan. Tuesday up-to-date information at www.toxicology.org 187
47 th Annual Meeting & ToxExpo Program Description (Continued) Tuesday Abstract # Abstract # #1158 Poster Board Number.......................................558 EFFECTS OF IN UTERO AND LACTATIONAL EXPOSURE TO 2, 3, 7, 8-TETRACHLORODIBENZO-P-DIOXIN (TCDD) ON REPRODUCTIVE FUNCTION IN MALE RHESUS MONKEYS. A. Arima 1,5 , T. Tateishi 1 , K. Hanaki 1 , Y. Nishida 1 , J. Okayama 1 , T. Iahara 1 , R. Nagata 1 , S. Kubota 2 , T. Fukusato 3 , H. Sumida 4 , M. Yasuda 4 and S. Kamimura 5 . 1 Drug Safety Research Laboratories, Shin Nippon Biomedical Laboratories, Ltd., (SNBL), Kagoshima, Japan, 2 Department of Life Science, Graduate School of Arts and Sciences, University of Tokyo, Himeji, Japan, 3 Department of Pathology, Teikyo University School of Medicine, Tokyo, Japan, 4 Department of Clinical Radiology, Faculty of Health Sciences, Hiroshima International University, Higashihiroshima, Japan and 5 Laboratory of Theriogenology, Faculty of Agriculture, University of Miyazaki, Miyazaki, Japan. Sponsor: R. Nagata. #1159 Poster Board Number.......................................559 ATSDR’S ACUTE MINIMAL RISK LEVEL FOR HEPTACHLOR. Z. A. Rosemond 1 , L. Ingerman 2 and C. V. Smith 1 . 1 Division Of Toxicology and Environmental Medicine, Agency for Toxic Substances and Disease Registry, Atlanta, GA and 2 Environmental Science Center, Syracuse Research Corporation, Syracuse, NY. Sponsor: R. Williams. #1160 Poster Board Number.......................................560 ABSENCE OF DEVELOPMENTAL TOXICITY IN EMBRYOFETAL AND PRE- AND POSTNATAL DEVELOPMENT STUDIES IN CYNOMOLGUS MACAQUES FOLLOWING ANTAGONISM OF IL-12/23 ACTIVITY WITH USTEKINUMAB (CNTO 1275). C. Sachs 1 , N. Imai 2 , S. Oneda 2 , H. Tsusaki 2 , A. Schantz 1 , J. Marini 1 , D. Graden 1 , G. Treacy 1 and P. Martin 1 . 1 Centocor R&D Inc, Radnor, PA and 2 Shin Nippon Biomedical Laboratories, Kagoshima, Japan. #1161 Poster Board Number.......................................561 SUBLETHAL TCDD EXPOSURE DURING EARLY STAGES OF DEVELOPMENT INDUCES CRANIOFACIAL, CARDIAC, AND REPRODUCTIVE TOXICITY IN ADULT ZEBRAFISH. T. King Heiden 1 , J. Spitsbergen 2 , K. M. Xiong 3 , W. Heideman 1,3,4 and R. E. Peterson 1,4 . 1 Molecular and Environ Toxicol Center, UW-Madison, Madison, WI, 2 Center for Fish Disease Research, Oregon State University, Corvallis, OR, 3 Depart Biomed Chem, UW-Madison, Madison, WI and 4 School of Pharmacy, UW-Madison, Madison, WI. Tuesday Afternoon, March 18 1:00 PM to 4:30 PM Exhibit Hall POSTER SESSION: RISK ASSESSMENT RESEARCH Chairperson(s): Gunda Reddy, U.S. Army Center for Health Promotion and Preventive Medicine, Aberdeen Proving Ground, MD and Jane Ellen Simmons, U.S. EPA, Research Triangle Park, NC. Displayed: 1:00 PM–4:30 PM Attended: 1:00 PM–2:45 PM #1162 Poster Board Number.......................................601 THE PHTHALATE ESTERS: PHARMACODYNAMIC (PD) VS. PHARMACOKINETIC (PK) FACTORS AFFECTING POTENCY IN TESTOSTERONE- MEDIATED DEVELOPMENTAL EFFECTS. R. A. Clewell 1 , J. Campbell 2 , H. Clewell 2 , K. Gaido 2 and M. Andersen 2 . 1 Environmental Sciences and Engineering, University of North Carolina at Chapel Hill, Research Triangle Park, NC and 2 The Hamner Institutes, Research Triangle Park, NC. #1163 Poster Board Number.......................................602 SODIUM PERFLUOROHEXANOATE: ORAL REPEATED DOSE SUBCHRONIC, ONE-GENERATION REPRODUCTION, GENOTOXICITY, AND DEVELOPMENTAL TOXICOLOGY. B. P. Slezak, T. L. Serex, S. E. Loveless, R. C. Buck and S. H. Korzeniowski. E.I. DuPont de Nemours & Co Inc., Wilmington, DE. #1164 Poster Board Number.......................................603 TOXICOLOGY AND SENESCENCE: BASELINE VARIABILITY AND TOLUENE EFFECTS ON MOTOR FUNCTION IN AGING BROWN NORWAY RATS. R. C. MacPhail, J. D. Farmer and K. A. Jarema. NHEERL, U.S. EPA, Research Triangle Park, NC. #1165 Poster Board Number.......................................604 VALIDATION OF A MORBIDITY SCORE IN A STUDY OF BOTULINUM TOXIN A. R. Ellis 1 , C. Gennings 1 , J. Benson 2 and B. Tibbetts 2 . 1 Biostatistics, Virginia Commonwealth University, Richmond, VA and 2 Lovelace Respiratory Research Institute, Albuquerque, NM. #1166 Poster Board Number.......................................605 DNA ADDUCT FORMATION OF LOW DOSE 13C2H2 LABELED METHYLMETHANE SULPHONATE. E. F. Tita, G. Boysen, V. Afonin, L. Collins and J. A. Swenberg. Environmental Science and Engineering, UNC Chapel Hill, Chapel Hill, NC. #1167 Poster Board Number.......................................606 IN VITRO ASSESSMENT OF HUMAN SKIN METABOLISM OF AROMATIC AMINE HAIR DYES. C. Goebel 1,3 , G. Kunze 2,3 , G. Waterval 2,3 , T. Sieber 2,3 , A. Zeller 2,3 and S. Pfuhler 2,3 . 1 CPS, Wella Service GmbH, Darmstadt, Germany, 2 CPS, Wella- Cosmital, Marly, Switzerland and 3 CPS, Procter & Gamble Company, Cincinnati, OH. Sponsor: F. Gerberick. 188 SOT’s 47 th Annual Meeting
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