Annual Meeting Program - Society of Toxicology

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Society of Toxicology 2008 Program Description (Continued) Abstract # Wednesday Afternoon, March 19 1:00 PM to 4:30 PM Exhibit Hall Developmental Basis of Disease POSTER SESSION: DEVELOPMENTAL NEUROTOXICITY Chairperson(s): Joseph Breier, University of North Carolina, Chapel Hill, NC. Displayed: 1:00 PM–4:30 PM Attended: 1:00 PM–2:45 PM #1691 Poster Board Number.......................................101 ETHANOL INHIBITS CARBACHOL- INDUCED AXON OUTGROWTH IN HIPPOCAMPAL NEURONS BY INHIBITING ERK1/2. K. L. VanDeMark, M. Guizzetti, G. Giordano and L. G. Costa. Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA. #1692 Poster Board Number.......................................102 MODERATE MATERNAL IRON INADEQUACY WORSENS NEUROBEHAVIORAL OUTCOMES IN A RAT MODEL OF DEVELOPMENTAL ETHANOL EXPOSURE. T. Tran 1 , E. S. Rufer 2,3 and S. M. Smith 2,3 . 1 Department of Psychology, East Carolina University, Greenville, NC, 2 Department of Nutritional Sciences, University of Wisconsin-Madison, Madison, WI and 3 Molecular & Environmental Toxicology Center, University of Wisconsin-Madison, Madison, WI. #1693 Poster Board Number.......................................103 ETHANOL INHIBITS HIPPOCAMPAL NEURON DIFFERENTIATION INDUCED BY CARBACHOL-TREATED ASTROCYTES. M. Guizzetti, G. Giordano, N. Moore and L. G. Costa. Env. Occ. Health Sci., University of Washington, Seattle, WA. #1694 Poster Board Number.......................................104 ETHANOL INHIBITS MUSCARINIC RECEPTOR-INDUCED RELEASE BY ASTROCYTES OF EXTRACELLULAR PROTEINS INVOLVED IN NEURONAL DEVELOPMENT. N. Moore 1 , M. Guizzetti 1 , G. Giordano 1 and L. G. Costa 1,2 . 1 Department of Environmental & Occupational Health Sciences, University of Washington, Seattle, WA and 2 Department of Human Anatomy, Pharmacology and Forensic Sciences, University of Parma Medical School, Parma, Italy. #1695 Poster Board Number.......................................105 THE ROLE OF NRF2 IN DOMOIC ACID-INDUCED EFFECTS ON EARLY NEURODEVELOPMENT. Q. H. Le, S. Hong, X. Yu and E. M. Faustman. Environmental and Occupational Health Sciences, University of Washington, Seattle, WA. Abstract # #1696 Poster Board Number.......................................106 THE PROTECTIVE EFFECT OF L-CARNITINE ON PHENCYCLIDINE- INDUCED CORTICAL APOPTOSIS IN THE DEVELOPING RAT. X. Zou 1 , S. Y. Boctor, 1 , N. Sadovova 2 , S. Ferguson 1 , M. G. Paule 1 , W. Slikker 1 and C. Wang 1 . 1 Division of Neurotoxicology, National Center for Toxicological Research, Jefferson, AR and 2 Toxicologic Pathology Associates, National Center for Toxicological Research, Jefferson, AR. #1697 Poster Board Number.......................................107 FLUORESCENT MOLECULAR IMAGING OF TRANSGENIC MICE FOR NEUROTOXICITY AND COMPOUND SCREENING. L. Zhuo, G. Ho, S. Kumar, C. Zhang, X. Min and I. Kng. Institute of Bioengineering and Nanotechnology, Singapore, Singapore. Sponsor: J. O’Callaghan. #1698 Poster Board Number.......................................108 EVALUATION OF HUMAN NEURAL PROGENITOR CELLS FOR DEVELOPMENTAL NEUROTOXICITY SCREENING: TIME COURSE OF EFFECTS ON CELL PROLIFERATION AND VIABILITY. J. M. Breier 1,2 and T. J. Shafer 2 . 1 Curriculum in Toxicology, University of North Carolina, Chapel Hill, NC and 2 Neurotoxicology, U.S. EPA, RTP, NC. #1699 Poster Board Number.......................................109 COMPARISON OF NEUROSCREEN-1 AND CEREBELLAR GRANULE CELL CULTURES FOR EVALUATING NEURITE OUTGROWTH USING THE ARRAYSCAN HIGH CONTENT ANALYSIS SYSTEM. N. M. Radio, T. M. Freudenrich, B. L. Robinette and W. R. Mundy. Neurotoxicology Division, U.S. EPA, Research Triangle Park, NC. #1700 Poster Board Number.......................................110 EFFECTS OF PRENATAL EXPOSURE TO 1-BROMOPROPANE ON NEURONAL EXCITABILITY IN THE HIPPOCAMPUS OF OFFSPRING. Y. Fueta 1 , T. Ishidao 1 , S. Ueno 2 , Y. Yoshida 3 and H. Hori 1 . 1 Environmental Management, School of Health Sciences, University of Occupational and Environmental Health, Kitakyushu, Japan, 2 Pharmacology, School of Midicine, University of Occupational and Environmental Health, Kitakyushu, Japan and 3 Immunology, School of Midicine, University of Occupational and Environmental Health, Kitakyushu, Japan. Sponsor: N. Kunugita. #1701 Poster Board Number.......................................111 RETINOIC ACID AFFECTS CHOLESTEROL HOMEOSTASIS IN ASTROCYTES: A NEW MECHANISM OF TERATOGENESIS? J. Chen, L. G. Costa, K. Dao, J. F. Oram and M. Guizzetti. DEOHS, University of Washington, Seattle, WA. Wednesday up-to-date information at www.toxicology.org 237
47 th Annual Meeting & ToxExpo Program Description (Continued) Wednesday Abstract # Abstract # #1702 Poster Board Number.......................................112 PATHOLOGICAL ASSESSMENT OF THE NERVOUS SYSTEM OF RAT OFFSPRING EXPOSED TO ACRYLAMIDE DURING THE GESTATION AND LACTATION PERIODS – A PRELIMINARY STUDY. M. Takahashi 1 , M. Shibutani 1,2 , K. Inoue 1 , H. Fujimoto 1 , M. Hirose 1,3 , M. Yoshida 1 and A. Nishikawa 1 . 1 Division Pathol., National . Inst. Health Sci., Tokyo, Japan, 2 Lab. Vet. Pathol., Tokyo University Agricultural Technol., Tokyo, Japan and 3 Food Safety Commission, Tokyo, Japan. #1703 Poster Board Number.......................................113 DEVELOPMENTAL EXPOSURE TO PERCHLORATE ALTERS SYNAPTIC TRANSMISSION IN HIPPOCAMPUS OF THE ADULT RAT. M. E. Gilbert 1 and L. Sui 1,2 . 1 Neurotoxicology Division, U.S. EPA, Research Triangle Park, NC and 2 National Rsearch Council, Washington, DC. #1704 Poster Board Number.......................................114 THE ROLE OF N-METHYL-D-ASPARTATE RECEPTORS IN POLYCHLORINATED BIPHENYL-MEDIATED NEUROTOXICITY. N. Leopold and C. Laurie. Community Health, University of Northern British Columbia, Prince George, BC, Canada. #1705 Poster Board Number.......................................115 POLYCHLORINATED BIPHENYLS (PCBs) INFLUENCE DENDRITIC GROWTH IN CULTURED HIPPOCAMPAL NEURONS VIA RYANODINE RECEPTOR (RYR)- DEPENDENT ACTIVATION OF CAM KINASE I. V. A. Ledoux 1 , G. A. Wayman 2 , I. N. Pessah 3 and P. J. Lein 1 . 1 CROET, Oregon Health & Science University, Portland, OR, 2 VCAPP, Washington State University, Pullman, WA and 3 VM:Molecular Biosciences and CCEH, University of California, Davis, CA. #1706 Poster Board Number.......................................116 INDUCTION OF NEUROTOXICITY IN FETAL BRAIN AFTER PRENATAL EXPOSURE TO VALPROATE. M. Kuwagata 1,2 , T. Ogawa 2 , S. Shioda 2 and T. Nagata 1 . 1 Toxicology, Hatano Research Institute, Hadano, Japan and 2 Department of Anatomy I, Showa University Shool of Medicine, Tokyo, Japan. #1707 Poster Board Number.......................................117 IN UTERO AND LACTATIONAL EXPOSURE TO A LOW DOSE OF TCDD OR TBDD PERTURBS PAIRED ASSOCIATIVE LEARNING OF MALE RAT OFFSPRING. T. Endo, M. Kakeyama and C. Tohyama. Division of Environmental Health Sciences, Center for Disease Biology and Integrative Medicine(CDBIM), Graduate School of Medicine, The University of Tokyo, Bunkyo-ku, Tokyo, Japan. #1708 Poster Board Number.......................................118 HIGHLY BROMINATED DIPHENYL ETHERS, PBDE 209, 206 AND 203 AFFECT DEVELOPMENTAL MARKER PROTEINS IN THE NEONATAL MOUSE BRAIN. H. Viberg, N. Johansson and P. Eriksson. Environmental Toxicology, Uppsala University, Uppsala, Sweden. #1709 Poster Board Number.......................................119 EXPRESSION AND FUNCTIONAL CHARACTERIZATION OF THE ORGANIC CATION TRANSPORTER-3 IN MOUSE ASTROCYTES. J. Panza 1 , R. Aras 1 , N. Ballatori 1 and K. Tieu 1,2 . 1 Environmental Medicine, University of Rochester, Rochester, NY and 2 Center for Aging and Development, University of Rochester, Rochester, NY. #1710 Poster Board Number.......................................120 PERFLUOROOCTANESULFONATE DEVELOPMENTAL NEUROTOXICITY STUDY IN RATS. D. J. Ehresman 1 , A. T. Eveland 2 , J. D. Zitzow 2 , J. A. Bjork 3 , D. G. Stump 4 , S. Chang 1 , K. B. Wallace 3 and J. L. Butenhoff 1 . 1 3M Company, St. Paul, MN, 2 Pace Analytical Services, Inc., Minneapolis, MN, 3 University of Minnesota, Duluth, MN and 4 WIL Research, Ashland, OH. #1711 Poster Board Number.......................................121 BISPHENOL A IS RELEASED FROM POLYCARBONATE DRINKING BOTTLES AND MIMICS THE NEUROTOXIC ACTIONS OF ESTROGEN IN DEVELOPING CEREBELLAR NEURONS. S. M. Belcher, H. H. Le, E. M. Carlson and J. P. Chua. Pharmacology, University of Cincinnati, Cincinnati, OH. #1712 Poster Board Number.......................................122 HEARING IMPAIRMENT FOLLOWING DEVELOPMENTAL EXPOSURE TO PCBs IN A RAT MODEL. B. E. Powers, J. J. Sable, P. K. Pandya and S. L. Schantz. University of Illinois @ U-C, Urbana, IL. #1713 Poster Board Number.......................................123 RDX PILOT FOR DEVELOPMENTAL NEUROTOXICITY TEST IN RATS. A. Hess- Ruth, L. Crouse and L. Roszell. Directorate of Toxicology, U.S. Army Center for Health Promotion and Preventive Medicine, Aberdeen Proving Ground, MD. #1714 Poster Board Number.......................................124 EFFECTS OF 7-NITROINDAZOLE AND MELATONIN ON KETAMINE-INDUCED NEUROTOXICITY IN POSTNATAL DAY 3 (PND-3) MONKEY FRONTAL CORTICAL CULTURES. N. Sadovova 1 , T. Patterson 2 , X. Zou 2 , X. Zhang 2 , J. Hanig 3 , M. Paule 2 , S. Ali 2 , W. Slikker 2 and C. Wang 2 . 1 Toxicologic Pathology Associates, Jefferson, AR, 2 Division of Neurotoxicology, National Center for Toxicological Research/FDA, Jefferson, AR and 3 Center for Drug Evaluation and Research/FDA, Silver Spring, MD. #1715 Poster Board Number.......................................125 NEUROTOXICITY OF SOME NEW ANTICONVULSANT N, N’-SUBSTITUTED SPIROHYDANTOINS. R. A. Stephani 1,2 , P. Gutta 1 and H. Patel 1 . 1 Pharmaceutical Sciences, St. John’s University, Jamaica, NY and 2 Chemistry, Saint John’s University, Jamaica, NY. 238 SOT’s 47 th Annual Meeting
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