Annual Meeting Program - Society of Toxicology

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Society of Toxicology 2008 Program Description (Continued) Abstract # Wednesday Morning, March 19 9:00 AM to 12:30 PM Exhibit Hall POSTER SESSION: MECHANISMS OF CARCINOGENESIS Chairperson(s): Burra Madhukar, Michigan State University, East Lansing, MI and Lori White, U.S. EPA, Research Triangle Park, NC. Displayed: 9:00 AM–12:30 PM Attended: 9:00 AM–11:00 AM #1407 Poster Board Number.......................................101 CIGARETTE SMOKE (CS) CAUSES FORMATION OF REGIONS OF ALTERED DNA METHYLATION (RAMS) IN SENCAR MOUSE LUNG. J. I. Goodman 1 , J. M. Phillips 2 , G. M. Curtin 3 and D. J. Doolittle 3 . 1 Pharmacology & Toxicology, Mich. State U., East Lansing, MI, 2 Biochem. & Mol. Biol., Mich. State U., East Lansing, MI and 3 Research and Development, R. J. Reynolds Tobacco Co., Winston-Salem, NC. #1408 Poster Board Number.......................................102 VARIABLE HISTONE MODIFICATIONS AT THE A VY METASTABLE EPIALLELE. D. C. Dolinoy and R. L. Jirtle. Department of Radiation Oncology, Duke University, Durham, NC. #1409 Poster Board Number.......................................103 MEASUREMENT OF CIGARETTE SMOKE CONDENSATE-INDUCED STRUCTURAL AND FUNCTIONAL ALTERATIONS IN BRONCHIAL CELLS USING QUANTITATIVE HIGH CONTENT SCREENING. C. A. Carter, K. D. Ergle and J. T. Hamm. Life Sciences, Lorillard Tobacco Company, Greensboro, NC. #1410 Poster Board Number.......................................104 IDENTIFICATION OF EARLY MOLECULAR EVENTS UPON PEROXISOME PROLIFERATOR EXPOSURE IN THE RODENT LIVER. H. Ren, B. Vallanat and J. C. Corton. ORD/NHEERL/ECD, U.S. EPA, Durham, NC. #1411 Poster Board Number.......................................105 THE ROLE OF TUMOR PROMOTER- INDUCED PKC ACTIVATION IN THE REGULATION OF HUMAN EQUILIBRATIVE NUCLEOSIDE TRANSPORTER 1 EXPRESSION AND ACTIVITY. S. Jones 1 , A. V. Leisewitz 2 and L. M. Graves 2,1 . 1 Curriculum in Toxicology, University of North Carolina- Chapel Hill, Chapel Hill, NC and 2 Department of Pharmacology, University of North Carolina-Chapel Hill, Chapel Hill, NC. #1412 Poster Board Number.......................................106 CONSTITUTIVELY ACTIVE B-RAF DOES NOT REGULATE CYCLIN D1 IN 2, 3, 5-TRIS- (GLUTATHION-S-YL) HYDROQUINONE TRANSFORMED, TUBEROUS SCLEROSIS-2 NULL CELLS. J. D. Cohen, M. T. Labenski, T. J. Monks and S. S. Lau. Pharmacology and Toxicology, University of Arizona, Tucson, AZ. Abstract # #1413 Poster Board Number.......................................107 PROAPOPTOTIC INTERACTIONS OF NON- PLANAR PCBs IN RAT LIVER EPITHELIAL CELLS: ROLE OF MITOGEN-ACTIVATED PROTEIN KINASES. B. V. Madhukar and G. Chen. Pediatrics/Human Development, Michigan State University, East Lansing, MI. #1414 Poster Board Number.......................................108 17a-ETHINYLESTRADIOL ESPOSURE HINDERS HEPATIC NUCLEOTIDE EXCISION REPAIR IN ZEBRAFISH. G. Mayer and E. G. Notch. University of Maine, Orono, ME. #1415 Poster Board Number.......................................109 INTERACTION BETWEEN THE ARYL HYDROCARBON RECEPTOR (AHR) AND THE RAS/RAF SIGNALING PATHWAYS IS REQUIRED FOR AHR- INDUCED EXPRESSION OF MATRIX METALLOPROTEINASES. K. A. Murphy and L. A. White. Rutgers University, New Brunswick, NJ. #1416 Poster Board Number.......................................110 MICRORNAOME CHANGES AND BREAST CANCER DRUG RESISTANCE. J. Filkowski 1 , V. Tryndyak 2 , I. Pogribny 2 and O. Kovalchuk 1 . 1 University of Lethbridge, Lethbridge, AB, Canada and 2 NCTR, Jefferson, AR. #1417 Poster Board Number.......................................111 OLD NSAID BUT NEW ANTICANCER AGENT: TOLFENAMIC ACID INHIBITS PANCREATIC CANCER GROWTH AND SENSETIZES TUMOR TO RADIOTHERAPY THROUGH DOWNREGULATION OF SP PROTEINS. M. Abdelrahim 1,2 , S. Konduri 1 , S. Safe 3 and J. Colon 1 . 1 Cancer Research Institute, M. D. Anderson Cancer Center Orlando, Orlando, FL, 2 Burnett College of Biomedical Sciences, University of Central Florida, Orlando, FL and 3 Veterinary Physiology and Pharmacology, Texas A&M University, College Station, TX. #1418 Poster Board Number.......................................112 BORIC ACID AS A NOVEL ENDOPLASMIC RETICULUM MODULATOR AND CALCIUM RELEASE ANTAGONIST IN DU-145 PROSTATE CANCER CELLS. K. A. Henderson, S. Kobylewski and C. Eckhert. Molecular Toxicology IDP, UCLA, Los Angeles, CA. #1419 Poster Board Number.......................................113 EFFECT OF SODIUM ARSENITE ON METALLOTHIONEIN 1/2 AND P53 PROTEIN LEVELS AND ITS POTENTIAL RELATIONSHIP WITH CELL CYCLE ALTERATIONS IN MCF-7 CELLS. A. D. Ríos-Pérez 1 , M. E. Cebrián 1 , R. Ruiz-Ramos 2 and L. T. Lopez-Carrillo 2 . 1 Toxicology, Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional, Mexico City, DF, Mexico and 2 Centro de Investigacion en Salud Poblacional, Instituto Nacional de Salud Publica, Cuernavaca, Morelos, Mexico. Wednesday up-to-date information at www.toxicology.org 213
47 th Annual Meeting & ToxExpo Program Description (Continued) Wednesday Abstract # Abstract # Wednesday Morning, March 19 9:00 AM to 12:30 PM Exhibit Hall POSTER SESSION: GENE REGULATION AND GENOMIC APPROACHES Chairperson(s): Yue Wern Huang, University of Missouri, Rolla, MO. Displayed: 9:00 AM–12:30 PM Attended: 11:00 AM–12:30 PM #1420 Poster Board Number.......................................114 AHR PROTEIN INTERACTIONS: BUILDING A COMPREHENSIVE PROTEIN INTERACTION NETWORK. D. M. Tappenden 1,4 , L. Yang 2 , R. S. Thomas 2 and J. J. LaPres 1,3,4 . 1 Biochemistry, MSU, East Lansing, MI, 2 The Hamner Institutes for Health Sciences, Research Triangle Park, NC, 3 The National Food Safety and Toxicology Center, MSU, East Lansing, MI and 4 Center for Integrative Toxicology, MSU, East Lansing, MI. #1421 Poster Board Number.......................................115 IDENTIFYING THE MECHANISM OF AHR-MEDIATED OFF-TARGET EFFECTS INDUCED BY A-277249 USING CHIP-ON- CHIP TECHNOLOGY. Y. Yang, R. Ciurlionis, E. A. Blomme and J. F. Waring. R463, Abbott Laboratories, Abbott Park, IL. #1422 Poster Board Number.......................................116 TEMPORAL AND DOSE-DEPENDENT AHR- MEDIATED GENE EXPRESSION ANALYSIS IN HUMAN LIVER ADULT STEM CELLS. S. Kim 1,2,3 , E. Dere 1,2 , L. D. Burgoon 1,2 , C. C. Chang 2,4 and T. R. Zacharewski 1,2,3 . 1 Department of Biochemistry & Molecular Biology, Michigan State University, East Lansing, MI, 2 National Food Safety & Toxicology Center, Michigan State University, East Lansing, MI, 3 Center for Integrative Toxicology, Michigan State University, East Lansing, MI and 4 Department of Pediatrics & Human Development, Michigan State University, East Lansing, MI. #1423 Poster Board Number.......................................117 CHARACTERIZATION OF GENE EXPRESSION RESPONSES ELICITED BY TOXIC AND NON-TOXIC AHR LIGANDS IN MURINE HEPA1C1C7 CELLS. E. Dere 1,2 , A. W. Lee 1,2 , M. S. Kiewitt 1,2 , L. D. Burgoon 1,2 and T. R. Zacharewski 1,2 . 1 Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI and 2 National Food Safety and Toxicology Center, Michigan State University, East Lansing, MI. #1424 Poster Board Number.......................................118 CONSERVED AND DIVERGENT GENE EXPRESSION PROFILES DURING ETHYNYLESTRADIOL, TAMOXIFEN AND O, P’-DDT INDUCED UTEROTROPHY IN THE RAT UTERUS. J. C. Kwekel 1,2 , K. J. Williams 2,3 and T. R. Zacharewski 1,2 . 1 Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI, 2 Center for Integrative Toxicology and National Food Safety and Toxicology Center, Michigan State University, East Lansing, MI and 3 Department of Pathobiology and Diagnostic Investigation, Michigan State University, East Lansing, MI. #1425 Poster Board Number.......................................119 STEROIDOGENIC ACUTE REGULATORY PROTEIN AS A TARGET FOR ORGANOCHLORINE PESTICIDES IN LARGEMOUTH BASS (MICROPTERUS SALMOIDES). M. S. Prucha 1 , W. Rees 2 , D. Barber 2 and N. D. Denslow 2 . 1 Pharmacology and Therapeutics, University of Florida, Gainesville, FL and 2 Physiological Sciences, University of Florida, Gainesville, FL. #1426 Poster Board Number.......................................120 STRESS ASSAY ENSEMBLE RESPONSE TO ENVIRONMENTAL CHEMICALS IN DIFFERENT HUMAN CELL TYPES. S. Simmons and R. Ramabhadran. NHEERL, U.S. EPA, Durham, NC. #1427 Poster Board Number.......................................121 EVALUATION OF ESTROGENIC ACTIVITY OF PHTHALATE ESTERS BY DNA MICROARRAY ANALYSIS. M. Parveen 1 , A. Inoue 2 , R. Ise 1 , M. Tanji 2 and R. Kiyama 1,2 . 1 Signaling Molecules Research Laboratory, National Institute of Advanced Industrial Science and Technology, Tsukuba, Japan and 2 InfoGenes Co., Ltd, Kashiwa, Japan. Sponsor: M. Sato. #1428 Poster Board Number.......................................122 FULL-GENOME ANALYSIS OF ALTERNATIVE SPLICING IN MOUSE LIVER AFTER HEPATOTOXICANT EXPOSURE. B. Vallanat, J. S. Lee, W. Ward, H. Ren, M. Rosen, S. Hester, S. Nesnow, C. Lau, D. Delker and J. C. Corton. NHEERL, U.S. EPA, Durham, NC. #1429 Poster Board Number.......................................123 NON-LINEAR LOW DOSE RESPONSE IN METHYL METHANESULFONATE (MMS)-TREATED RATS AS MEASURED BY MULTIPLE ENDPOINTS. M. J. LeBaron, H. L. Kan, D. R. Geter, L. H. Pottenger, F. Zhang, M. R. Schisler, M. J. Bartels and B. B. Gollapudi. Toxicology & Environmental Research & Consulting, The Dow Chemical Company, Midland, MI. #1430 Poster Board Number.......................................124 ACRYLAMIDE AND GLYCIDAMIDE- INDUCED MITOCHONDRIAL GENE EXPRESSION PROFILES IN BIG BLUE TRANSGENIC MICE. M. G. Manjanatha 1 , C. L. Moland 2 , W. S. Branham 2 , S. D. Shelton 1 , E. Tareke 3 , T. Lee 3 , A. Aidoo 1 , J. C. Fuscoe 2 and V. G. Desai 2 . 1 Genetic Toxicology, FDA/NCTR, Jefferson, AR, 2 Division of Systems Toxicology, National Center for Toxicological Research, Jefferson, AR and 3 Personalized Medicine and Nutrition, National Center for Toxicological Research, Jefferson, AR. Sponsor: B. Parsons. #1431 Poster Board Number.......................................125 GENE EXPRESSION CHANGES IN BLOOD LEUKOCYTES INDICATIVE OF D-SERINE EXPOSURE. A. Soto 1 , M. Davison 2 , N. DelRaso 1 and V. Chan 1 . 1 HEPB, AFRL, Dayton, OH and 2 ORISE, Dayton, OH. Sponsor: D. Mattie. 214 SOT’s 47 th Annual Meeting
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