Annual Meeting Program - Society of Toxicology

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Society of Toxicology 2008 Program Description (Continued) Abstract # #2103 Poster Board Number.......................................159 THE EFFECT OF MANGANESE ACCUMULATION ON GLUTATHIONE METABOLISM IN RAT LIVER SUBCELLULAR FRACTIONS. K. Phillips, P. Cooney and K. Erikson. Nutrition, UNC-Greensboro, Greensboro, NC. #2104 Poster Board Number.......................................160 CHARACTERIZATION OF MANGANESE- INDUCED PRODUCTION OF REACTIVE OXYGEN SPECIES IN MICROGLIA: RELEVANCE TO DOPAMINERGIC NEURODEGENERATION. B. Liu 1,3 , Y. Liu 1 , G. Dutta 1 , D. S. Barber 2 and P. Zhang 1 . 1 Department of Pharmacodynamics, University of Florida, Gainesville, FL, 2 Department of Physiological Sciences, University of Florida, Gainesville, FL and 3 McKnight Brain Institute, University of Florida, Gainesville, FL. #2105 Poster Board Number.......................................201 ALTERED COPPER TRANSPORT AT RAT BLOOD-CSF BARRIER FOLLOWING SUBCHRONIC EXPOSURE TO MANGANESE. Y. Zhang and W. Zheng. School of Health Sciences, Purdue University, West Lafayette, IN. #2106 Poster Board Number.......................................202 COPPER IS REQUIRED FOR HYPOXIA- INDUCIBLE FACTOR-1 ACTIVATION. W. Feng, F. Ye, Z. Zhou and Y. Kang. Department of Medicine, University of Louisville, Louisville, KY. #2107 Poster Board Number.......................................203 COPPER SUPPLEMENTATION REVERSES CARDIOMYOCYTE HYPERTROPHY THROUGH A DIRECT REDUCTION IN THE CELL SIZE. Y. Zhou, Y. Jiang and Y. Kang. University of Louisville, Louisville, KY. #2108 Poster Board Number.......................................204 APOPTOSIS GENE EXPRESSION IN HUMAN EPIDERMAL KERATINOCYTES TREATED WITH SODIUM ARSENITE USING REAL TIME PCR ARRAY. J. Mo 1 , Y. Xia 2 and J. L. Mumford 3 . 1 Center for Environmental Medicine, Asthma and Lung Biology, University of North Carolina, Chapel Hill, NC, 2 Inner Mongolia Center for Endemic Disease and Control, Huhhot, Inner Mongolia, China and 3 NHEERL/HSD, U.S. EPA, Research Triangle Park, NC. Sponsor: M. Madden. #2109 Poster Board Number.......................................205 EFFECTS OF GLUTATHIONE AND HYDROGEN PEROXIDE ON THE STABILITY OF BILIARY METABOLITES OF INTRAVENOUSLY INJECTED ARSENITE IN RATS. Y. Kobayashi 1 and S. Hirano 2 . 1 Environmental Health Sciences Division, National Institute for Environmental Studies, Tsukuba, Japan and 2 Reserch Center for Environmental Risk, National Institute for Environmental Studies, Tsukuba, Japan. Abstract # #2110 Poster Board Number.......................................206 ARSENITE MODIFIES P53-MEDIATED RESPONSE TO CISPLATIN-INDUCED DNA DAMAGE IN OVARIAN CANCER CELLS. C. Muenyi 1 , A. A. Pandit 1 and J. States 1,2 . 1 Pharmacology & Toxicology, University of Louisville, Louisville, KY and 2 Ctr. Environmental Genomics & Integrative Biology, U. Louisville, Louisville, KY. #2111 Poster Board Number.......................................207 EXPOSURE TO ARSENIC DISRUPTS VEGF-DIRECTED VASCULOGENESIS CAUSING SUBSEQUENT PLACENTAL INSUFFICIENCY AND SPONTANEOUS ABORTION. J. Coffin 1 , K. Lewis 1 , F. Pereira 1 , D. Brooks 1 , W. He 2 and H. D. Beall 1 . 1 CEHS, University Montana, Missoula, MT and 2 Env. Health, University Pittsburgh, Pittsburgh, PA. #2112 Poster Board Number.......................................208 SENSITIVITY TO SODIUM ARSENITE DEPENDS UPON A FUNCTIONAL SPINDLE CHECKPOINT. S. C. McNeely 1 , A. C. Belshoff 1 , B. F. Taylor 1 , M. J. McCabe 2 and J. States 1 . 1 Pharmacology, University of Louisville, Louisville, KY and 2 Environmental Medicine, University of Rochester, Rochester, NY. #2113 Poster Board Number.......................................209 EXPRESSION OF KERATIN 6A AND KERATIN 16 IN ARSENITE AND CADMIUM TRANSFORMED UROTSA CELL LINES IS INDUCED IN VIVO AND IS ASSOCIATED WITH SQUAMOUS DIFFERENTIATION. S. Somji, L. Cao, X. Zhou, M. Sens, S. H. Garrett and D. A. Sens. Pathology, University of North Dakota, Grand Forks, ND. #2114 Poster Board Number.......................................210 CHARACTERIZATION OF TUMOR HETEROTRANSPLANTS PRODUCED FROM INDEPENDENTLY GENERATED CLONES OF ARSENITE AND CADMIUM TRANSFORMED HUMAN UROTHELIAL CELLS. X. Zhou, S. Somji, S. H. Garrett, M. Sens and D. A. Sens. Pathology, University of North Dakota, Grand Forks, ND. #2115 Poster Board Number.......................................211 METHYLATED BISMUTH, BUT NOT BISMUTH CITRATE OR BISMUTH GLUTATHIONE INDUCES CYTO- AND GENOTOXIC EFFECTS IN HUMAN CELLS IN VITRO. E. Dopp 1 , U. von Recklinghausen 1 , L. M. Hartmann 2 , S. Rabieh 2,3 , J. Hippler 2 , A. V. Hirner 2 and A. W. Rettenmeier 1 . 1 Institute of Hygiene and Occupational Medicine, University of Duisburg-Essen, Essen, NRW, Germany, 2 Institute of Environmental Analysis, University of Duisburg- Essen, Essen, NRW, Germany and 3 Chemical Research Department, Matís, Reykjavík, Iceland. Sponsor: G. Alink. #2116 Poster Board Number.......................................212 CO-ADMINISTRATION OF COBALT CHLORIDE PROTECTS AGAINST LIVER INJURY INDUCED BY CADMIUM CHLORIDE IN MICE. S. Himeno, K. Nakashima and H. Fujishiro. Fac. of Pharmaceutical Sciences, Tokushima Bunri University, Tokushima, Japan. Sponsor: M. Satoh. Thursday up-to-date information at www.toxicology.org 271
47 th Annual Meeting & ToxExpo Program Description (Continued) Thursday Abstract # Abstract # #2117 Poster Board Number.......................................213 CELLULAR VITAMIN C INCREASES CHROMATE TOXICITY VIA A DEATH PROGRAM REQUIRING MISMATCH REPAIR BUT NOT P53. M. F. Reynolds and A. Zhitkovich. Pathology and Laboratory Medicine, Brown University, Providence, RI. #2118 Poster Board Number.......................................214 V-PROLI/NO, A NITRIC OXIDE DONOR PRODRUG, PROTECTS LIVER CELLS FROM ARSENIC-INDUCED TOXICITY AND APOPTOSIS. W. Qu 1 , A. Dill 1 , J. E. Saavedra 2 , L. K. Keefer 3 and M. Waalkes 1 . 1 Inorganic Carcinogenesis Section, LCC, NCI at NIEHS, Research Triangle Park, NC, 2 SAIC, NCI at Frederick, Frederick, MD and 3 CS, LCC, NCI at Frederick, Frederick, MD. #2119 Poster Board Number.......................................215 ELIMINATION OF THIOL CONJUGATES OF INORGANIC MERCURY AND THE ROLE OF THE MULTIDRUG RESISTANCE PROTEIN 2. C. Bridges, R. K. Zalups and L. Joshee. Division of Basic Medical Sciences, Mercer University School of Medicine, Macon, GA. #2120 Poster Board Number.......................................216 REACTIVE OXYGEN SPECIES SCAVENGERS REDUCE HYPERPROLIFERATION AND ANCHORAGE INDEPENDENT GROWTH OF UROTSA CELLS CHRONICALLY EXPOSED TO MONOMETHYLARSONOUS ACID. K. E. Eblin, S. E. Buffington and A. J. Gandolfi. College of Pharmacy-Toxicology, University of Arizona, Tucson, AZ. #2121 Poster Board Number.......................................217 ALPHA-TOCOPHEROL AVOIDS OVEREXPRESSION OF OCLUDIN AND DISORDER PATTERN OF CLAUDIN-2 LOCATION, AND MANTAINS PROXIMAL RENAL FUNCTION IN MICE EXPOSED TO DICHROMATE. L. Arreola-Mendoza 1 , J. L. Reyes 2 , M. E. Mendoza 2 and L. M. Del Razo 1 . 1 Toxicology, Cinvestav-IPN, Mexico D.F, Mexico and 2 Physiology & Biophysics, Cinvestav-IPN, Mexico D.F., Mexico. #2122 Poster Board Number.......................................218 THE ROLE OF NADPH OXIDASE VERSUS MITCHONDRIA IN ARSENIC TRIOXIDE- INDUCED APOPTOSIS. K. K. Mann, M. Kourelis, Z. Diaz, S. Marcoux and W. H. Miller. Lady Davis Institute for Medical Research, McGill University, Montreal, QC, Canada. Thursday Morning, March 20 8:30 AM to 12:00 NOON Ballroom 6C & E POSTER SESSION: METHOD DEVELOPMENT, AUTOIMMUNITY, AND DISEASE MECHANISMS IN IMMUNOTOXICOLOGY Chairperson(s): Lin Mantell, St. Johns University, Queens, NY and Tai Guo, Virginia Commonwealth University, Richmond, VA. Displayed: 8:30 AM–12:00 NOON Attended: 8:30 AM–10:15 AM #2123 Poster Board Number.......................................221 EVIDENCE OF AUTOIMMUNE-RELATED EFFECTS OF TRICHLOROETHYLENE IN STUDIES IN MICE AND HUMANS. G. S. Cooper, S. L. Makris and J. Jinot. ORD - NCEA, U.S. EPA, Washington, DC. #2124 Poster Board Number.......................................222 ENHANCED INDUCIBLE NITRIC OXIDE SYNTHASE EXPRESSION AND NITROTYROSINE FORMATION IN TRICHLOROETHENE-MEDIATED AUTOIMMUNE RESPONSE. G. Wang, J. Wang and M. Khan. Pathology, University of Texas Medical Branch, Galveston, TX. #2125 Poster Board Number.......................................223 EVIDENCE FOR POSTNATAL AUTOIMMUNE DISEASE FOLLOWING DEVELOPMENTAL EXPOSURE TO TCDD IN 24 WEEK-0LD C57BL/6 MICE. S. D. Holladay 2 , A. Mustafa 1,2 , M. Goff 1,2 , S. Witonsky 1 , R. P. Kerr 1,2 , C. D. Reilly 1 , P. Sponenberg 2 and R. M. Gogal 1,2 . 1 Center for Molecular Medicine and Infectious Disease, VA Tech, Blacksburg, VA and 2 Biomedical Sciences and Pathobiology, VA Tech, Blacksburg, VA. #2126 Poster Board Number.......................................224 PERINATAL TCDD EXPOSURE MODULATES B CELL DEVELOPMENT IN JUVENILE C57BL/6 MICE. R. M. Gogal 1,2 , H. Groch 1,2 , A. Mustafa 1,2 and S. D. Holladay 2 . 1 Center for Molecular Medicine and Infectious Disease, VA Tech, Blacksburg, VA and 2 Biomedical Sciences and Pathobiology, VA Tech, Blacksburg, VA. #2127 Poster Board Number.......................................225 EXACERBATION OF POSTNATAL AUTOIMMUNE DISEASE IN 24 WEEK- 0LD SNF1 LUPUS NEPHRITIS MICE PERINATALLY EXPOSED TO TCDD. A. Mustafa 1,2 , S. D. Holladay 2 , M. Goff 1,2 , S. Witonsky 1 , R. P. Kerr 1,2 , C. D. Reilly 1,2 , P. Sponenberg 2 and R. M. Gogal 1,2 . 1 Center for Molecular Medicine and Infectious Disease, VA Tech, Blacksburg, VA and 2 Biomedical Sciences and Pathobiology, VA Tech, Blacksburg, VA. 272 SOT’s 47 th Annual Meeting
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