Annual Meeting Program - Society of Toxicology

Society of Toxicology 2008
Continuing Education
Continuing Education Courses
The Continuing Education Program offers a wide range of courses that
cover state-of-the-art knowledge in toxicology, as well as new developments
in toxicology and related disciplines. Courses can be applied
toward certifying and licensing board requirements and may also be used
for recertification with the American Board of Toxicology (ABT). Both
basic and advanced course topics are offered. The basic course is intended
to provide a broad overview of an area or to assist individuals in learning
new techniques or approaches. The advanced course is intended to be of
interest to individuals with previous knowledge of the subject or already
working in the field.
All courses will be held on Sunday, March 16, 2008, at the Washington
State Convention and Trade Center. Please check the signage in the registration
area and at the CE Booth for room assignments. Note: Your course
materials will be available in the room immediately prior to the course
(they will not be available at the registration area). If you have your
course ticket, go directly to the assigned course room. If you have not
received your course ticket or have not registered, please go to the registration
area on Saturday afternoon/evening or on Sunday morning. If you
have misplaced your ticket, please go to one of the Continuing Education
Booths, Level 6, at the Convention Center on Sunday. The booth will be
open from 6:30 AM–5:15 PM.
*Indicates the Primary Special Interest Group (SIG), Specialty Section
(SS), or Regional Chapter (RC) endorser.
7:00 AM–7:45 AM Sunrise (SR) Continuing Education
Course:
1. Mini-Pigs as an Alternative Non-Rodent Species in Toxicology and
Safety Studies
8:15 AM–12:00 NOON Morning (AM) Continuing
Education Courses:
2. Introduction to Pathology for Toxicologists and Study Directors
3. Stem Cells and their Multi-Potential Uses and Potential Dangers
4. Dose-Response Modeling for Occupational and Environmental
Risk Assessment
5. The Use of Transgenic Animal Technology in Toxicological
Research
6. Process-Based Approaches to Modulating Gene and Protein
Expression In Vivo and In Vitro
7. Basic Embryology and Developmental Toxicology
1:15 PM–5:00 PM Afternoon (PM) Continuing Education
Courses:
8. Introduction to Pathology for Toxicologists and Study Directors
9. Nanotoxicology: The Science of Developing a Safe Technology
10. Clinical Dose Setting for Biotherapeutics
11. Use of Data for Development of Uncertainty Factors in
Non-Cancer Risk Assessment
Sunday, March 16
7:00 AM–7:45 AM
Level 6 (See signage at CE Booth for room locations)
Mini-Pigs As an Alternative Non-Rodent Species in
Toxicology and Safety Studies
SR01
Basic
Chairperson(s): Glenn Washer, LAB Research Inc., Montreal, Quebec,
Canada and Andrew Makin, LAB Research Denmark (Scantox),
Copenhagen, Denmark
Endorsed by:
Animals in Research Committee*
Comparative and Veterinary Specialty Section
Dermal Toxicology Specialty Section
This course will focus on the regulatory acceptability and utility of
mini-pigs as an alternative to traditional non-rodent species for nonclinical
studies of pharmaceuticals. Attention will be given to their use in
general toxicology and safety studies, including non-routine routes and
embryofetal development studies.
The choice of non-rodent species for safety assessment of new pharmaceuticals
is becoming increasingly important. For many years researchers
have adopted the paradigm that we use the dog, and if the dog is no
good, then we use the primate. With the ever increasing ethical concerns
relating to the use of primates, and other groups concerned with the use
of “man’s best friend”, attention has been increasingly focussed on the
potential of the pig and mini-pig. An increasing appreciation of the similarities
between man and the pig in structure of skin, gastrointestinal tract,
urogenital system, and metabolism is the principal reason for the increased
popularity. There are 13 species of pig, however, biomedical research has
been largely restricted to the domestic pig derived from the Eurasian wild
boar (Sus scofa) and the warthog (Phacochoerus africanus). Smaller
strains (“mini-pigs”) have increasingly come to prominence in non-clinical
testing and are now widely employed as non-rodent alternatives for
regulatory-driven safety programs. For pharmaceutical compounds whose
route is dermal in man, there is a growing realization that the mini-pig is a
valid model. Pig skin has been shown to be anatomically, physiologically,
biochemically, and immunologically similar to human skin. Although
the use of the mini-pig in the development of dermal products is well
accepted by regulators, its suitability for a wide range of other study
types has been somewhat overlooked although in many ways it is more
representative of man than other species. The mini-pig is now recognized
as a suitable non-rodent species for efficacy and safety studies of many
types of pharmaceutical products. Mini-pigs are suitable experimental
models using many of the commonly applied techniques used in other
species, and they have also been used as alternative non-rodent species for
embryofetal studies.
• Introduction, Glenn Washer, LAB Research Inc., Montreal, Canada
• Practical Considerations of the Use of Mini-Pigs in Toxicology and
Safety Studies, Andrew Makin, LAB Research Denmark (Scantox),
Copenhagen, Denmark
• The Mini-Pig in Non-Clinical Toxicology—a Regulatory
Perspective, Abigail Jacobs, U.S. FDA, Silver Spring, MD
CE
12. Essential Informatics for Toxicologists: Knowledge Management
End-to-End
13. Epidemiology for Toxicologists: Introduction
up-to-date information at www.toxicology.org 71