Annual Meeting Program - Society of Toxicology

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Society of Toxicology 2008 Program Description (Continued) TUESDAY EVENING Abstract # WEDNESDAY MORNING Tuesday Evening, March 18 6:00 PM to 9:00 PM See Daily Pocket Calendar on pages 9 and 10 for room listings Special Interest Group Meetings/Receptions: Association of Scientists of Indian Origin in America, Toxicologists of African Origin Wednesday Morning, March 19 7:00 AM to 8:30 AM See Daily Pocket Calendar on page 13 for room listings Regional Chapter Meetings/Breakfasts: Michigan, midwest Tuesday Evening, March 18 6:00 PM to 7:30 PM See Daily Pocket Calendar on pages 9 and 10 for room listings Specialty Section Meetings/Receptions: Biological Modeling, Carcinogenesis, Drug Discovery Toxicology, Inhalation and Respiratory, Metals, Neurotoxicology, Regulatory and Safety Evaluation Tuesday Evening, March 18 6:00 PM to 8:30 PM See Daily Pocket Calendar on page 10 for room listings Regional Chapter Meetings/Receptions: National Capital Area, Southeastern Wednesday Morning, March 19 7:30 AM to 8:50 AM Room 618 ROUNDTABLE SESSION: HAZARD VS. RISK FOR CHEMICAL REGULATION Chairperson(s): George Daston, Procter & Gamble Company, Cincinnati, OH and Robert Lindenschmidt, Procter & Gamble Company, Cincinnati, OH. Endorsed by: Occupational and Public Health Specialty Section Regulatory and Safety Evaluation Specialty Section* Reproductive and Developmental Toxicology Specialty Section Risk Assessment Specialty Section Different governmental organizations, and even different industries, have taken different approaches to decision-making about the safety of chemicals. U.S. and Canadian regulatory agencies take a risk-based approach to chemical regulation, whereas the E.U. approach is hazard-based. Many retailers of products that contain chemicals, such as WalMart, are also starting to adopt a hazard-based expectations for their suppliers. Both approaches have their supporters, and both have positive and negative aspects. They may lead to very different decisions regarding acceptability based on the same data set. Since these decisions have important public health and economic impliations, it is important to understand more about them. The purpose of this Roundtable will be to present the current lay of the land in chemical regulation, and to highlight the differences in decisions that are often made by the two approaches, as well as their consequences. Wednesday #1326 7:30 HAZARD VS. RISK FOR CHEMICAL REGULATION. G. Daston and R. Lindenschmidt. Procter & Gamble, Cincinnati, OH. 7:35 HAZARD-BASED CLASSIFICATION SYSTEMS AND PRODUCT SUBSTITUTION. Lauren Zeise 7:40 HAZARD-BASED BINNING AS A BASIS FOR DECISION MAKING. Barbara Beck 7:45 THE NEW DRIVING FORCE FOR HAZARD- BASED APPROACHES - THE RETAIL TRADE. Thomas Osimitz 7:50 THE IMPORTANCE OF DOSE-RESPONSE AND EXPOSURE ASSESSMENT IN CHEMICAL REGULATION. James Bus 7:55 VCCEP AS AN EXAMPLE OF AN EFFECTIVE RISK-BASED REGULATORY PROCESS. Michael Dourson 8:00 LIMITATIONS IN THE USE OF DATA ON INTERMEDIATE STEPS FOR QUANTIFYING HUMAN RISK. Kenny Crump 8:05 PANEL DISCUSSION. up-to-date information at www.toxicology.org 203
47 th Annual Meeting & ToxExpo Program Description (Continued) Abstract # Abstract # Wednesday Morning, March 19 7:30 AM to 8:50 AM Room 615 Wednesday Morning, March 19 7:30 AM to 8:50 AM Room 608 Wednesday ROUNDTABLE SESSION: RECONCILING SCIENTIFIC AND ETHICAL CONCERNS IN THE USE OF ANIMALS FOR TOXICOLOGICAL RESEARCH Chairperson(s): Mara Seeley, Environmental Health & Engineering, Newton, MA and Thomas Lewandowski, Gradient Corporation, Seattle, WA. Endorsed by: Animals in Research Committee Ethical, Legal, and Social Issues Specialty Section* In Vitro and Alternative Methods Specialty Section This roundtable will explore the tension between scientific necessity and ethical concerns regarding the use of animals in toxicological research. At present, scientific research depends on animal studies to address questions about efficacy and safety of potential drugs, and the potential hazards of chemicals. The Society of Toxicology and other societies have addressed ethical issues of using animals in research, and government regulations specifically address the scientific and ethical treatment of animals. In addition, there are ongoing efforts to develop alternative methods that could replace, refine, or reduce the use of experimental animals in toxicological research. For example, new methods with more specific and less variable endpoints may enable experimental designs that require fewer animals. Following a summary of recent trends in the use of animals in research, this roundtable will discuss the report recently released by the National Research Council regarding efforts to develop alternatives to animal testing, and how these alternatives can be implemented. We will then examine how advances in disciplines such as genomics might contribute to reductions in animal use. We will also consider refinement alternatives as well as approaches for recognizing and minimizing distress that animals may experience in toxicity studies. Finally, this roundtable will discuss limitations on the use of animal alternatives for toxicity testing in the regulatory arena – both for drug safety testing and for support of human health risk assessments. #1327 7:30 RECONCILING SCIENTIFIC AND ETHICAL CONCERNS IN THE USE OF ANIMALS FOR TOXICOLOGICAL RESEARCH. T. A. Lewandowski. Gradient Corporation, Seattle, WA. 7:35 TOXICITY TESTING IN THE TWENTY- FIRST CENTURY. Mel Andersen 7:41 ALTERNATIVES TO ANIMAL TESTS IN TOXICOLOGY - MORE THAN WISHFUL THINKING. Thomas Hartung 7:47 RECOGNITION AND ALLEVIATION OF DISTRESS IN LABORATORY ANIMALS. Joanne Zurlo 7:53 HUMANE SCIENCE: REFINEMENT ALTERNATIVES. Alan Goldberg 7:59 DRUG SAFETY EVALUATION AND ALTERNATIVE TEST METHODS: CHALLENGES AND OPPORTUNITIES. Lynnda Reid 8:05 PHASING OUT ANIMAL TESTING AS NEW TEST STRATEGIES DEVELOP. Lauren Zeise 8:11 QUESTIONS FROM THE AUDIENCE. Career Development ROUNDTABLE SESSION: TOXICOLOGY TRAINING NEEDS: NEW FACES AND NEW TOOLS FOR THE 21 ST CENTURY Chairperson(s): William Slikker, National Center for Toxicological Research, Jefferson, AR and John Bucher, U.S. Department of Health & Human Services, Rockville, MD. Endorsed by: Academy of Toxicological Sciences Career Resource and Development Committee* Postdoctoral Assembly Student Advisory Council There is growing concern within the discipline of toxicology with regard to the projected retirement of experienced toxicologists and the toxicology training pipeline from both a numbers and depth of training perspective. This problem is only becoming more acute due to budgetary constraints, regulatory and policy shifts and the advent of new chemical and biological challenges resulting from innovative and technology driven product development. Toxicologists are being asked to address safety issues for novel nanotechnology products, plant-made pharmaceuticals and industrials, combination therapeutics and concerns related to potential chemical and biological terror agents in a timely and cost effective manner. To address these issues, the next generation of toxicologists will need new tools and cutting edge training, and they must be produced in sufficient numbers to effectively replace the current cadre of toxicologists as they retire. A necessary first step in assuring the availability of qualified toxicologists is to begin a dialogue among the various potential employers on projected current and future needs in toxicology and what type of training experience would be most advantageous as the discipline moves into the 21 st century. There is also a need to develop a clear picture of the number of new toxicologists that will be needed over the next 10 years. This session will focus on the number of toxicologists and the required skill sets needed as discussed by representatives from the industry, academic, research, consulting and government sectors and will be a positive step forward by addressing these needs at a meeting where most of the concerned toxicologists and many of those responsible for training and hiring toxicologists will be in attendance. #1328 7:30 TOXICOLOGY TRAINING NEEDS: NEW FACES AND NEW TOOLS FOR THE 21 ST CENTURY. W. Slikker 1 and J. Bucher 2 . 1 Office of the Director, FDA / NCTR, Jefferson, AR and 2 Associate Director NTP, NIEHS / NIH, Research Triangle Park, NC. 7:34 TRAINING NEEDS FOR TOXICOLOGISTS: A VIEW FROM EUROPE AND THE PHARMACEUTICAL INDUSTRY. Ruth Roberts 7:53 TRAINING NEEDS FOR TOXICOLOGISTS: A VIEW FROM THE ACADEMIA TRENCHES. David Eaton 8:12 THE ACADEMIC TRAINING NEEDS FOR TOXICOLOGIST: A GOVERNMENT PERSPECTIVE. Bruce Fowler 8:31 TOXICOLOGY TRAINING TO MEET THE NEEDS OF THE BIOTECHNOLOGY INDUSTRY. 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Annual Meeting Sponsors (as of Janu
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Annual Meeting Program - Society of Toxicology

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