Annual Meeting Program - Society of Toxicology

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Society of Toxicology 2008 Program Description (Continued) Abstract # #2077 Poster Board Number.......................................133 OXIDATIVE POTENTIAL AND CELLULAR EFFECTS INDUCED BY PM10 OBTAINED IN MEXICO CITY AND AT A RECEPTOR SITE. A. R. Osornio-Vargas 1,2 , R. Quintana 1 , V. Gomez 2 , J. Serrano 2 , I. Vazquez 1 , G. Flores 1 , J. Miranda 2 , E. Vega 3 , H. Ruiz 3 , S. Escalona 3 , B. de Foy 5 , A. de Vizcaya 4 , C. Garcia 1 , I. Rosas 2 and L. Tan Molina 6 . 1 INCan, Mexico City, DF, Mexico, 2 UNAM, Mexico City, DF, Mexico, 3 IMP, Mexico City, DF, Mexico, 4 CINVESTAV, Mexico City, DF, Mexico, 5 St. Louis University, St. Louis, MO and 6 MCE2, San Diego, CA. #2078 Poster Board Number.......................................134 DNA DAMAGE BY A TWO-ELECTRON OXIDATION (EPOXIDATION) MECHANISM. L. M. Ball 1 , W. Ye 1 , J. E. Olson 1 , K. M. Koshlap 2 , K. Jayaraj 1 , G. Boysen 1 , A. Gold 1 and R. Sangaiah 1 . 1 Environmental Sciences and Engineering, University of North Carolina at Chapel Hill, Chapel Hill, NC and 2 School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC. #2079 Poster Board Number.......................................135 OXIDATIVE DNA DAMAGE IN NCI-H292 CELLS EXPOSED TO CIGARETTE SMOKE AT THE AIR-LIQUID INTERFACE. D. Thorne, T. Oke, M. McEwan, E. D. Massey and M. Gaca. R&D Centre, British American Tobacco, Southampton, United Kingdom. Sponsor: J. Seagrave. #2080 Poster Board Number.......................................136 UNCONJUGATED BILIRUBIN CAUSES CHANGES IN INTRACELLULAR REDOX STATUS, CHANGES TO THE DISULFIDE PROTEOME, AND UPREGULATION OF SEVERAL GENES INVOLVED IN ER STRESS. G. H. Oakes 1 , A. Awaysheh 2 , L. B. Dale 3 and J. R. Bend 1,2 . 1 Physiology and Pharmacology, Siebens Drake Medical Research Institute, University of Western Ontario, London, ON, Canada, 2 Pathology, Siebens-Drake Medical Research Insititute, University of Western Ontario, London, ON, Canada and 3 Cell Biology Group, Robart’s Research Institute, London, ON, Canada. #2081 Poster Board Number.......................................137 MULTI-PARAMETER ANALYSIS OF OXIDATIVE STRESS IN INDIVIDUAL CELLS USING HIGH CONTENT IMAGING AND QUANTITATIVE ANALYSIS. K. K. Opperman, B. S. Mandavilli and R. N. Ghosh. Research and Development, Thermo Fisher Scientific, Rockford, IL. Sponsor: A. Barchowsky. #2082 Poster Board Number.......................................138 APPLICATION OF CONFOCAL AUTOFLUORESCENCE SPECTROSCOPY FOR ANALYSIS OF NADH STATUS IN THE HEPG2 AND THE C6 GLIOMA CELLS AND ITS CHANGE UPON EXPOSURE TO CD. M. S. Yang 1 , J. Zheng 2 , W. Y. Ng 1 , W. Zheng 2 , T. Lin 1 and J. Y. Qu 2 . 1 Department of Biology, Hong Kong Baptist University, Kowloon, Hong Kong, China and 2 Department of Electronic & Computer Engineering, Hong Kong University of Science and Technology, Kowloon, Hong Kong, China. Abstract # #2083 Poster Board Number.......................................139 HUMAN IN VITRO HEMOLYSIS MODEL TO ASSESS DRUG-INDUCED HEMOLYTIC EFFECTS. A. E. Vickers 1 , R. L. Fisher 2 , J. R. Sinclair 1 and S. Morris 1 . 1 Drug Safety Evaluation, Allergan Inc, Irvine, CA and 2 Vitron Inc, Tucson, AZ. #2084 Poster Board Number.......................................140 A NEW 405 NM LASER EXCITABLE FLUORESCENT PROBE OF INTRACELLULAR THIOLS FOR FIXED END-POINT IMAGE BASED ASSAYS. Y. Chen, R. Aggeler, J. A. Bradford, M. S. Janes, Y. Wu, H. Kang and I. Johnson. Molecular Probes, Eugene, OR. Sponsor: J. Lin. Thursday Morning, March 20 8:30 AM to 12:00 NOON Ballroom 6C & E POSTER SESSION: METALS II Chairperson(s): Steve Lasley, University of Illinois, Peoria, IL. Displayed: 8:00 AM–12:00 NOON Attended: 10:15 AM–12:00 NOON #2085 Poster Board Number.......................................141 ROLE OF METALLOTHIONEIN IN HEPATIC TOXICITY CAUSED BY VANADIUM COMPOUND IN MICE. T. Hasegawa 1 , M. Satoh 2 , A. Shimada 3 and Y. Seko 1 . 1 Environmental Biochemistry, Yamanashi Institute of Environmental Sciences, Fujiyoshida, Yamanashi, Japan, 2 Aichi Gakuin University, Nagoya, Aichi, Japan and 3 Tottori University, Tottori, Japan. #2086 Poster Board Number.......................................142 ULTRASTRUCTURAL NUCLEAR CHANGES IN LYMPHOCYTES AFTER INHALED VANADIUM EXPOSURE. F. I. Teresa 1 , V. Rodriguez-Lara 1 , G. Piñon-Zarate 1 , M. Rojas- Lemus 1 , L. Colin-Barenque 2 , P. Bizarro-Nevares 1 and P. Mussali-Galante 1 . 1 Biología Celular y Tisular, UNAM, Mexico City, Mexico and 2 Neuromorfologia, FES Iztacala, UNAM, Mexico City, Mexico. #2087 Poster Board Number.......................................143 HIF-1a AND COX-2 MEDIATE SYNERGISTIC RELEASE OF ANGIOGENIC FACTORS FROM HUMAN LUNG FIBROBLASTS IN RESPONSE TO NICKEL AND MICROBIAL STIMULI. K. A. Brant, R. M. Ward and J. P. Fabisiak. Environmental and Occupational Health, University of Pittsburgh, Pittsburgh, PA. #2088 Poster Board Number.......................................144 OVEREXPRESSION OF F-BOX PROTEIN, HRT3 OR YLR224W, CONFERS RESISTANCE TO METHYLMERCURY IN YEAST CELLS. G. Hwang and A. Naganuma. Tohoku University, Sendai, Japan. Thursday up-to-date information at www.toxicology.org 269
47 th Annual Meeting & ToxExpo Program Description (Continued) Thursday Abstract # Abstract # #2089 Poster Board Number.......................................145 THE ROLE OF MRP2 AND GLUT2 TRANSPORTERS IN THE METABOLISM OF ARSENITE BY PRIMARY HUMAN HEPATOCYTES. F. S. Walton 1,2 , Z. Drobna 1 and M. Styblo 1 . 1 Department of Nutrition, University of North Carolina, Chapel Hill, NC and 2 Center for Environmental Medicine, Asthma and Lung Biology, University of North Carolina, Chapel Hill, NC. #2090 Poster Board Number.......................................146 DNA DAMAGE IN HUMAN LYMPHOCYTES IN VITRO EXPOSED TO COMBINED METALS; ARSENIC, CADMIUM, COBALT AND CHROMIUM. N. Yoshioka, H. Nakashima, Y. Sano and K. Omae. Department of Preventive Medicine and Public Health, Keio University School of Medicine, Tokyo, Japan. #2091 Poster Board Number.......................................147 HETEROLOGOUS EXPRESSION SYSTEM IN YEAST REVEALED STRUCTURE- FUNCTION RELATIONSHIP IN METAL TRANSCRIPTION FACTOR, MTF-1. Y. Jin 1,2 , H. Al-Refai 2 and J. Freedman 1,2 . 1 NIEHS, Research Triangle Park, NC and 2 Duke University, Durham, NC. #2092 Poster Board Number.......................................148 UNDERSTANDING COBALT CHLORIDE- INDUCED LUNG INJURY THROUGH CYTOMETRIC, METABOLOMIC, PROTEOMIC, AND HISTOLOGICAL ANALYSIS OF BRONCHIOALVEOLAR LAVAGE FLUID (BALF). Y. Saini 1,4 , J. Harkema 2,3,4 and J. LaPres 1,3,5 . 1 Genetics, Michigan State University, East Lansing, MI, 2 Department of Pathobiology and Diagnostic Investigation, Michigan State University, East Lansing, MI, 3 The National Food Safety and Toxicology Center, Michigan State University, East Lansing, MI, 4 Center for Integrative Toxicology, Michigan State University, East Lansing, MI and 5 Biochemistry and Molecular Biology, Michigan State University, East Lansing, MI. #2093 Poster Board Number.......................................149 CHRONIC EXPOSURE TO ZINC CHROMATE INDUCES CHROMOSOME INSTABILITY IN HUMAN LUNG CELLS. A. Holmes 1,2 , Q. Qin 1,2 , J. L. Young 1,2 , K. Joyce 1,2 , H. Xie 1,2,3 , T. Cavas 1,2,4 and J. P. Wise 1,2,3 . 1 Wise Laboratory of Environmental and Genetic Toxicology, University of Southern Maine, Portland, ME, 2 Maine Center for Toxicology and Environmental Health, University of Southern Maine, Portland, ME, 3 Department of Applied Medical Science, University of Southern Maine, Portland, ME and 4 Department of Biology, Mersin University, Mersin, Turkey. #2094 Poster Board Number.......................................150 THE ULTRASTRUCTURAL EFFECTS OF COPPER DIMETHYLDITHIOCARBAMATE (CDDC) ON MATERNAL AND NEWBORN BRAINS OF LONG-EVANS RATS. B. Scharf 1 and L. D. Trombetta 2,1 . 1 Biology, St. Johns University, New York and 2 Pharmaceutical Sciences, St. Johns University, New York. #2095 Poster Board Number.......................................151 THE EFFECTS OF ZIRAM ON RAT HIPPOCAMPAL ASTROCYTES. A. Matei and L. D. Trombetta. Pharmaceutical Sciences, St. Johns University, New York. #2096 Poster Board Number.......................................152 STUDY OF INFLUENCE OF COMBINED INTRODUCTION OF MANGANESE AND PIRACETAM ON COGNITIVE FUNCTIONS IN WHITE RATS. A. N. Petrov. The Institute of Toxicology, St-Petersburg, Russian Federation. #2097 Poster Board Number.......................................153 IN VIVO RESPONSE TO SODIUM TUNGSTATE: A CYTOGENETIC ANALYSIS OF SPLENIC T CELLS AND PROFILE OF SYSTEMIC AND LOCALIZED CYTOKINE LEVELS. S. L. Prues, H. J. Fullenkamp, K. L. Hess, D. J. Wagner, G. D. Chapman and A. O. Olabisi. Environmental Health Effect Laboratory [EHEL], Naval Health Research Center, Wright Patterson Air Force Base, OH. #2098 Poster Board Number.......................................154 PHARMACOKINETICS OF TUNGSTEN (188W) FOLLOWING ACUTE SODIUM TUNGSTATE INHALATION IN RATS. D. J. Wagner 1 , P. M. Radcliffe 2 , A. O. Olabisi 1 , B. A. Wong 2 , M. F. Struve 2 , K. M. Attard 2 , E. Tewksbury 2 , P. G. Gunasekar 1 , G. D. Chapman 1 and D. C. Dorman 3 . 1 Environmental Health Effect Laboratory [EHEL], Naval Health Research Center, Wright Patterson Air Force Base, OH, 2 CIIT, The Hamner Institutes, Research Triangle Park, NC and 3 College of Veterinary Medicine, North Carolina State University, Raleigh, NC. #2099 Poster Board Number.......................................155 TUNGSTATE’S EFFECTS ON IMMUNE AND NON-IMMUNE HUMAN CELL TYPES WHEN ANALYZED IN VITRO. D. J. Carson 1,2 , A. Osterburg 2 , D. J. Wagner 1 , A. O. Olabisi 1 , P. G. Gunasekar 1 , G. Babcock 2 and G. D. Chapman 1 . 1 Cincinnati Shriner’s Hospital for Children, Cincinnati, OH and 2 Environmental Health Effect Laboratory [EHEL], Naval Health Research Center, Wright Patterson Air Force Base, OH. #2100 Poster Board Number.......................................156 ACUTE AND SUBACUTE TOXICITY OF ORALLY ADMINISTERED SODIUM TUNGSTATE IN SPRAGUE-DAWLEY RATS. W. C. McCain 1 , L. Crouse 1 , M. Thompson 1 , A. Hess-Ruth 1 , M. Quinn 1 , M. Bazar 1 , P. Beall 1 , K. Mozzachio 2 , H. El-Fawal 3 and G. Leach 1 . 1 Toxicology, U.S. Army Center for Health Promotion and Preventive Medicine, Aberdeen Proving Ground, MD, 2 Biotechnics, Hillsborough, NC and 3 Division of Health Professions and Natural Sciences, Mercy College, Dobbs Ferry, OH. #2101 Poster Board Number.......................................157 HEALTH EFFECTS OF EMBEDDED FRAGMENTS OF TUNGSTEN AND TUNGSTEN ALLOYS. L. E. Roszell 1 , A. Hess- Ruth 1 , P. Beall 1 and P. Catherine 2 . 1 U.S. Army CHPPM, Aberdeen Proving Ground, MD and 2 Biotechnics, LLC, Hillsborough, NC. #2102 Poster Board Number.......................................158 REMOVAL OF TISSUE MANGANESE BY P-AMINOSALICYLIC ACID (PAS) IN MANGANESE-EXPOSED RATS IN VIVO. W. Zheng 1 , Y. Zhang 1 , Y. Jiang 2 and W. Jiang 1 . 1 Purdue University, West Lafayette, IN and 2 Guangxi Medical University, Nanning, Guangxi, China. 270 SOT’s 47 th Annual Meeting
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