Fibrate Mechanism of Action - The Center for Cholesterol Management
Fibrate Mechanism of Action - The Center for Cholesterol Management
Fibrate Mechanism of Action - The Center for Cholesterol Management
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Fen<strong>of</strong>ibrate Tablet Pharmacokinetics<br />
Fen<strong>of</strong>ibrate is readily absorbed from the gastrointestinal<br />
tract<br />
Following oral administration fen<strong>of</strong>ibrate is rapidly<br />
hydrolyzed to by esterases to the active metabolite<br />
fen<strong>of</strong>ibric acid<br />
No unchanged fen<strong>of</strong>ibrate is detected in the serum<br />
Fen<strong>of</strong>ibric acid is primarily conjugated with glucuronic acid<br />
and excreted in the urine<br />
Neither fen<strong>of</strong>ibrate nor fen<strong>of</strong>ibric acid undergo oxidative<br />
metabolism by CYP450 enzymes<br />
• <strong>The</strong>y are weak inhibitors <strong>of</strong> CYP2C19, CYP2A6 and mild-moderate<br />
inhibitors <strong>of</strong> CYP2C9 and may potentiate coumarin-type<br />
anticoagulants
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