Fibrate Mechanism of Action - The Center for Cholesterol Management
Fibrate Mechanism of Action - The Center for Cholesterol Management
Fibrate Mechanism of Action - The Center for Cholesterol Management
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Fen<strong>of</strong>ibrate Decreases Sterol Absorption<br />
Apo B 48<br />
CE Poor<br />
Chylomicron<br />
NPC1L1 Protein<br />
ACAT<br />
X<br />
Less sterol<br />
absorption<br />
Nucleus DNA<br />
Lymphatic<br />
Vessel<br />
Valasek MA J<br />
Lipid Res<br />
2007;48:2725-35<br />
Fen<strong>of</strong>ibrate, via PPARα agonism reduces expression<br />
<strong>of</strong> NPC1L1 & decreases sterol absorption