Fibrate Mechanism of Action - The Center for Cholesterol Management

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Anti-inflammatory and Immunomodulatory Effects <strong>of</strong> PPARα Inflammatory response TNFα: tumor necrosis factor-α IFNγ: Interferon CRP: C-reactive protein COX-2: Cyclooxygenase-2 (affects prostaglandins) TF: Tissue factor in monocytes & macrophages Fibrinogen Lp-PLA 2 : Lp-associated Phospholipase A 2 IL-1, IL-2, IL-6: Interleukins (affect VSMC activation) MMPs: Metalloproteinases in macrophages • PPARα activators inhibit multiple inflammatory cytokines produced by T- lymphocytes by preventing Th0 cells from differentiating to more deleterious Th1 cells Marx N, et al. Circ Res. 2002;90:703-710. & Circ Res. 2004;94:1168-1178
Anti-inflammatory and Immunomodulatory Effects <strong>of</strong> PPARα Thrombosis Plaque stability • PPARα activators have antithrombotic effects by inhibiting tissue factor expression in monocytes and macrophages MMP-9: Metalloproteinase-9 TXS: Thromboxanes PAF: Platelet acetyl hydrolyzing factor TF: Tissue factor Neve BP, et al. Circulation. 2001;103:207-212. Marx N, et al. Circulation. 1999;99:3125-3131 and Circ Res. 2004;94:1168-1178
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Understanding the Mechanism of Acti
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Peroxisome Proliferorator-Activated
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Role of Peroxisome Proliferator- Ac
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Peroxisome Proliferator-Activated R
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Fibrates Fibrates are weak agonist
Page 11 and 12: Fibrate Chemical Structure
Page 13 and 14: Fibrates Clofibrate , the prototyp
Page 15 and 16: Fenofibrate Tablet Pharmacokinetics
Page 17 and 18: Fenofibric Acid 2-[4-(4-Chlorobenzo
Page 19 and 20: Fibrate Effect on Lipids and Lipopr
Page 21 and 22: Fibrate Mechanisms of Action De
Page 23 and 24: Fatty Acid Transport Proteins In
Page 25 and 26: Fibrates and Triacylglycerol Synthe
Page 27 and 28: Effects of Micronized Fenofibrate o
Page 29 and 30: Fibrates and Triacylglycerol Synthe
Page 31 and 32: Fibrates and Triglyceride Synthesis
Page 33 and 34: Fibrate Mechanisms of Action Fibra
Page 35 and 36: Fenofibrate Indices LPL Expression
Page 37 and 38: Hepatocyte Removal of VLDL PPARα A
Page 39 and 40: Enhanced VLDL Lipolysis in Insulin
Page 41 and 42: Decreased CETP Mediated CE/TG Excha
Page 43 and 44: Fibrate Effect on Lipids and Lipopr
Page 45 and 46: Additional Generation of Pre-beta H
Page 47 and 48: Fibrates and Macrophage Reverse Cho
Page 49 and 50: Direct RCT at the Hepatocyte Hepato
Page 51 and 52: The VA High-Density Lipoprotein Cho
Page 53 and 54: Fenofibrate Intervention and Event
Page 55 and 56: Fibrates and HDL Remodeling Drug in
Page 57 and 58: Fenofibrate Decreases Sterol Absorp
Page 59 and 60: Fibrate Effect on Non Lipid Novel M
Page 61: Anti-inflammatory and Immunomodulat
Page 65 and 66: Fenofibrate & Adiponectin in Patien
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Fibrate Mechanism of Action - The Center for Cholesterol Management

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