Fibrate Mechanism of Action - The Center for Cholesterol Management
Fibrate Mechanism of Action - The Center for Cholesterol Management
Fibrate Mechanism of Action - The Center for Cholesterol Management
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<strong>Fibrate</strong>s and Triacylglycerol Synthesis<br />
Hepatocyte<br />
Acyl-CoA<br />
NADPH<br />
Multiple steps<br />
Malonyl CoA<br />
Fatty acid synthase<br />
Saturated fatty acids<br />
NADPH<br />
Stearoyl CoA desaturase<br />
Fatty Acyl CoA<br />
GPAT<br />
Monounsaturated<br />
fatty acids<br />
Monoglycerol 3-phosphate<br />
DGAT<br />
Schematic representation <strong>of</strong><br />
the multiple steps between<br />
acyl-CoA to TG synthesis<br />
Fen<strong>of</strong>ibrate ester<br />
decreases de novo FA<br />
synthesis by repressing<br />
the expression <strong>of</strong><br />
SREBP1 and fatty acid<br />
synthase secondary to<br />
LXR antagonism.<br />
<strong>Fibrate</strong>s also<br />
noncompetitively inhibit<br />
diacylglycerol acyl<br />
transferase 2 (DGAT2),<br />
Triacylglycerols and<br />
phospholipids<br />
Pegorier JP et al. J Nutr 2004;134(9):2444S-9S<br />
Kesting GM et al. Drugs 2007;67:121-153
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