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Fibrate Mechanism of Action - The Center for Cholesterol Management

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Direct RCT at the Hepatocyte<br />

Hepatocyte<br />

RXR<br />

SR B1<br />

Hepatic Sinusoid<br />

PPARα<br />

Cholesteryl ester<br />

Free cholesterol<br />

Smaller alpha 3,4 HDL now<br />

available <strong>for</strong> relipidation or<br />

excretion<br />

ABCA1<br />

ABCG4<br />

ABCG5/8<br />

ABCB11<br />

Scavenger Receptor B1<br />

delipidation <strong>of</strong> large<br />

alpha 1 HDL<br />

Bile Duct

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