Fibrate Mechanism of Action - The Center for Cholesterol Management
Fibrate Mechanism of Action - The Center for Cholesterol Management
Fibrate Mechanism of Action - The Center for Cholesterol Management
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VLDL Lipolysis: PPARα Effect<br />
VLDL<br />
Receptor<br />
Lipoprotein Lipase (LPL)<br />
Apo C-III blocks LPL from<br />
the ligand Apo CII<br />
<strong>Fibrate</strong> PPARα agonism<br />
reduces Apo C-III production<br />
NEFA<br />
Apo C-III<br />
With Apo C-III absent, LPL<br />
can bind with Apo CII<br />
Hydrolysis <strong>of</strong> TG occurs<br />
Fruchart JC, et al. Cell Physiol Biochem 1999;9:139–149