Fibrate Mechanism of Action - The Center for Cholesterol Management
Fibrate Mechanism of Action - The Center for Cholesterol Management
Fibrate Mechanism of Action - The Center for Cholesterol Management
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Anti-inflammatory and<br />
Immunomodulatory Effects <strong>of</strong> PPARα<br />
Vasoconstriction<br />
Cell migration<br />
<br />
PPARα activators<br />
inhibit oxidized<br />
LDL stimulation <strong>of</strong><br />
endothelin-1<br />
production in<br />
endothelial cells<br />
improving<br />
endothelial<br />
reactivity<br />
ET-1: Endothelin-1, a potent vasoconstrictor<br />
eNOS: Endothelial NO synthase<br />
Ets-1: Endothelial cell transcription factor<br />
TXS: Thromboxanes<br />
Martin-Nizard F, et al. J Cardiovasc<br />
Pharmacol. 2002;40:822-831.<br />
Marx N, et al. Circ. 1999;99:3125-3131<br />
and Circ Res. 2004;94:1168 1178
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