Fibrate Mechanism of Action - The Center for Cholesterol Management

More documents

Recommendations

Info

Nuclear Transcription Factors Corepressor Complex HDAC NR RXR NR RE Coactivator Complex HAT Ligand NR RXR NR RE Histone Deacetylation Ligand Histone Acetylation Ligand binding Chromatin Remodeling Corepressors removal Transcription Recruitment of Coactivators Transcription Schematic representation of the regulation of gene transcription by nuclear receptors. In the unliganded state, nuclear receptors (NR) are bound to their specific responsive element (NRRE) generally as heterodimer with cisretinoic acid receptor (RXR). In this condition, heterodimers are associated with a multiprotein corepressor complex that contains histone deacetylase activity (HDAC). The deacetylated status of histones keeps the nucleosome in a conformation in which transcription is inhibited. Once a ligand binds to the receptor, the corepressor complex dissociates and a coactivator complex containing histone acetyltransferase activity (HAT) is recruited to the heterodimer. Acetylation of histone induces chromatin remodeling, a major event in activation of gene transcription. Duplus E et al. J Biol Chem 2000;275:30749-30552
Role of Peroxisome Proliferator- Activated Receptors α (PPAR-α) Nucleus with genes PPAR α Endoplasmic reticulum
Page 1 and 2: Understanding the Mechanism of Acti
Page 3: Peroxisome Proliferorator-Activated
Page 7 and 8: Peroxisome Proliferator-Activated R
Page 9 and 10: Fibrates Fibrates are weak agonist
Page 11 and 12: Fibrate Chemical Structure
Page 13 and 14: Fibrates Clofibrate , the prototyp
Page 15 and 16: Fenofibrate Tablet Pharmacokinetics
Page 17 and 18: Fenofibric Acid 2-[4-(4-Chlorobenzo
Page 19 and 20: Fibrate Effect on Lipids and Lipopr
Page 21 and 22: Fibrate Mechanisms of Action De
Page 23 and 24: Fatty Acid Transport Proteins In
Page 25 and 26: Fibrates and Triacylglycerol Synthe
Page 27 and 28: Effects of Micronized Fenofibrate o
Page 29 and 30: Fibrates and Triacylglycerol Synthe
Page 31 and 32: Fibrates and Triglyceride Synthesis
Page 33 and 34: Fibrate Mechanisms of Action Fibra
Page 35 and 36: Fenofibrate Indices LPL Expression
Page 37 and 38: Hepatocyte Removal of VLDL PPARα A
Page 39 and 40: Enhanced VLDL Lipolysis in Insulin
Page 41 and 42: Decreased CETP Mediated CE/TG Excha
Page 43 and 44: Fibrate Effect on Lipids and Lipopr
Page 45 and 46: Additional Generation of Pre-beta H
Page 47 and 48: Fibrates and Macrophage Reverse Cho
Page 49 and 50: Direct RCT at the Hepatocyte Hepato
Page 51 and 52: The VA High-Density Lipoprotein Cho
Page 53 and 54: Fenofibrate Intervention and Event
Page 55 and 56:
Fibrates and HDL Remodeling Drug in
Page 57 and 58:
Fenofibrate Decreases Sterol Absorp
Page 59 and 60:
Fibrate Effect on Non Lipid Novel M
Page 61 and 62:
Anti-inflammatory and Immunomodulat
Page 63 and 64:
Anti-inflammatory and Immunomodulat
Page 65 and 66:
Fenofibrate & Adiponectin in Patien
show all

Fibrate Mechanism of Action - The Center for Cholesterol Management

Create successful ePaper yourself

Delete template?

Save as template?