Fibrate Mechanism of Action - The Center for Cholesterol Management
Fibrate Mechanism of Action - The Center for Cholesterol Management
Fibrate Mechanism of Action - The Center for Cholesterol Management
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Peroxisome Proliferator-Activated Receptors-alpha<br />
<strong>The</strong> complex binds to the<br />
response elements in<br />
promoter regions <strong>of</strong> target<br />
gene<br />
Vascular Wall<br />
Macrophages<br />
Cardiac muscle<br />
Retinoid X Receptor<br />
Liver<br />
PPARα<br />
C<strong>of</strong>actors &<br />
Corepressors<br />
<strong>Fibrate</strong>s are<br />
PPARα agonists<br />
Adipocytes<br />
Nuclear<br />
transcription factors<br />
that regulate several<br />
genes involved with<br />
metabolic<br />
processes
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