Fibrate Mechanism of Action - The Center for Cholesterol Management
Fibrate Mechanism of Action - The Center for Cholesterol Management
Fibrate Mechanism of Action - The Center for Cholesterol Management
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Effects <strong>of</strong> Fen<strong>of</strong>ibrate and Simvastatin on<br />
HDL-related Biomarkers in Low-HDL Patients<br />
ABCA-I Mediated <strong>Cholesterol</strong> Efflux, %<br />
14 P=.015 P=.413<br />
12<br />
10<br />
8<br />
6<br />
4<br />
2<br />
0<br />
Baseline<br />
Fen<strong>of</strong>ibrate<br />
8 week Baseline 8 week<br />
Simvastatin<br />
Fen<strong>of</strong>ibrate, not the statin<br />
upregulates ABCA1<br />
ATP Binding Cassette Transporter A1<br />
Unlipidated pre β-HDL<br />
Larger α-HDL<br />
Franceschini G, et al. Atherosclerosis 195 (2007) 385–391
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