Fibrate Mechanism of Action - The Center for Cholesterol Management
Fibrate Mechanism of Action - The Center for Cholesterol Management
Fibrate Mechanism of Action - The Center for Cholesterol Management
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<strong>The</strong> VA High-Density Lipoprotein <strong>Cholesterol</strong><br />
Intervention Trial (VA HIT) Effects <strong>of</strong> Gemfibrozil<br />
Mean Percent Change<br />
40 Large LDL-P<br />
30<br />
20<br />
10<br />
0<br />
-10<br />
-20<br />
-30<br />
LDL-C<br />
3<br />
-5*<br />
LDL-P<br />
36*<br />
-20*<br />
Small<br />
LDL-P<br />
<strong>Fibrate</strong>s reduce Total LDL-P<br />
(decrease in small LDL-P and<br />
increase in large LDL-P) and<br />
also shift LDL size<br />
HDL-C<br />
6*<br />
TG<br />
-31<br />
* p
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