Fibrate Mechanism of Action - The Center for Cholesterol Management
Fibrate Mechanism of Action - The Center for Cholesterol Management
Fibrate Mechanism of Action - The Center for Cholesterol Management
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Fen<strong>of</strong>ibrate & LDL Receptors<br />
Proprotein Convertase Subtilisin / Kexin<br />
Type 9 (PCSK9) is a protease involved<br />
with LDL receptor catabolism<br />
PCSK9<br />
Response<br />
element<br />
Decreased PCSK9 activity<br />
mRNA<br />
X<br />
PCSK9<br />
LDL Receptors<br />
Decreased LDLr<br />
proteolysis<br />
Clearance <strong>of</strong> apoB/E particles with<br />
reduction in apoB and LDL-C<br />
PPAR-α agonism with fen<strong>of</strong>ibrate decreases PCSK9 activity<br />
Lambert G Endocrinology 2006;147:4985-95
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